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Psychiatric in-patients have a greatly elevated risk of suicide. We aimed to examine trends in in-patient suicide rates and determine if characteristics of in-patients who died by suicide have changed over time.
Methods
We identified all in-patients in England who died by suicide between 2009 and 2020 from the National Confidential Inquiry into Suicide and Safety in Mental Health. Suicide rates were calculated using data from Hospital Episodes Statistics.
Results
The rate of in-patient suicide per 100 000 bed days fell by 41.9% between 2009–2011 and 2018–2020. However, since 2016 the rate has remained static with no significant fall. Rates fell in men, those aged 30–59, and those with schizophrenia and other delusional disorders or personality disorder. Rates also fell for suicide by hanging (including hanging on the ward) and jumping. No falls were seen in suicide rates among women, younger and older age groups, and those with affective disorder. There was no indication of a transfer of risk to the post-discharge period or to home treatment/crisis care. More in-patients in the latter part of the study were aged under 25, were on authorised leave, and had psychiatric comorbidity.
Conclusions
In-patient suicide has significantly fallen since 2009, suggesting patient safety may have improved. The recent slowdown in the fall in rates, however, highlights that renewed preventative efforts are needed. These should include a greater focus on women, younger and older patients, and those with affective disorder. Careful reviews prior to granting leave are important to ensure a safe transition into the community.
Smartphone applications are used widely in healthcare, including antimicrobial applications such as Microguide. There has been no review of hospitals using this smartphone application for ENT conditions.
Methods
This study analysed all hospital accounts using Microguide and examined the ENT conditions that were listed.
Results
In total, 123 hospitals were included in this study; 45 ENT-related conditions were listed on Microguide across all hospitals, with an average of 8 conditions listed per hospital.
Conclusion
There is a significant disparity of ENT conditions listed on Microguide. A suggested list is recommended to be included for ENT departments using Microguide, to help improve antimicrobial stewardship for the specialty.
Some people diagnosed with schizophrenia are more prone to committing acts of serious violence, especially in the presence of drug or alcohol misuse. The rarity of homicide has meant that no large controlled study has previously examined clinical risk factors.
Aims
To determine the risk factors for homicide by males diagnosed with schizophrenia.
Method
A national nested case–control study of all previously admitted males diagnosed with schizophrenia, convicted of homicide between 1 January 1997 and 31 December 2012. Univariate and multivariable conditional logistic regression models were fitted to identify predictors of homicide in this population.
Results
During the observation period 160 male patients with schizophrenia and a history of psychiatric admission were convicted of homicide, and they were matched with 542 male control patients who had not been convicted of homicide. Patients who committed homicide were more likely to have a history of violence and comorbid personality disorder or drug misuse. They were more likely to have missed their last contact with services prior to the offence and to have been non-adherent with their treatment plan. Almost all (94%) of homicides were committed by patients who had a history of alcohol or drug misuse and/or who were not in receipt of planned treatment.
Conclusions
In England and Wales, homicides by patients with schizophrenia without substance misuse and in receipt of planned care are exceptionally rare. To prevent serious violence, mental health services should focus on drug and alcohol misuse, treatment adherence and maintaining contact with services.
We assessed the impact of a reflex urine culture protocol, an intervention aimed to reduce unnecessary urine culturing, in intensive care units at a tertiary care hospital. Significant decreases in urine culturing rates and reported rates of catheter-associated urinary tract infection followed implementation of the protocol.
Vascular biology is an exciting and rapidly advancing area of medical research, with many new and emerging pathophysiological links to an increasing number of diseases. This updated and expanded new edition takes full account of these developments and conveys the basic science underlying a wide range of clinical conditions including atherosclerosis, hypertension, diabetes, and pregnancy. As with the first edition, the publication provides an introductory account of vascular biology before leading on to explain mechanisms involved in disease processes. Other emerging topics include the role of nitric oxide and apoptosis in vascular biology. The breadth and range of subjects covered in this new edition do full justice to this increasingly important area of clinical research and medicine. This multidisciplinary approach will suit the needs of all those seeking to refresh their knowledge with the very latest advances from basic science through to clinical practice.
To say that Donne's religious world was, overwhelmingly, a Christian world may seem to be stating the obvious. But it is true not just in the simple, practical sense that the Christian religion was established by law, but also in the less obvious sense that it was hard for most people in the early modern period to think outside a Christian paradigm. In a letter to his friend Sir Henry Goodyer, Donne wrote simply that ''Religion is Christianity.'' By contemporary standards, this was a boldly inclusive definition of religion: one that embraced the whole of Christianity, Catholic and Protestant alike. Donne was at pains to stress that he had ''never fettered nor imprisoned the word Religion'' by confining it to any single Christian confession or ''immuring it in a Rome, or a Wittenberg, or a Geneva; they are all virtual beams of one Sun . . . connaturall pieces of one circle'' (Letters, p.29). Yet, by modern standards, it may strike us as a narrowly exclusive definition. For Donne, as for his contemporaries, Christianity held an absolute monopoly of religious truth; it was not merely part of religion, but the whole.
Infection with methicillin-resistant Staphylococcus aureus (MRSA) is increasing. It may be community or hospital acquired and is characteristically difficult to eradicate. Here we report a case of a two-year-old girl who sustained a traumatic tympanic membrane perforation following a minor burns injury. She was seen as an out-patient in a burns unit and subsequently developed MRSA otorrhoea. This was treated with a two-week course of fusidic acid topical drops. At three-week follow up the tympanic membrane had healed and the infection had healed completely. Fusidic acid is safe and effective in the treatment of MRSA otorrhoea. We need to maintain vigilance in the treatment of otorrhoea, as MRSA may become an increasingly common pathogen in the future.
The science of vascular biology has emerged and expanded rapidly over the past 25 years. Research in this area has increased understanding of a wide range of clinical conditions. This book provides a broad overview of the field for both specialist and newcomer to the field, and concise resource for the non-specialist. The multidisciplinary team of contributors covers topics ranging from normal and pathological aspects of endothelial cell function to the role of the vasculature in pregnancy, hypertension and atherosclerosis.
The authors have been selected for their ability to provide clear explanations of their area, resulting in an easily readable text with carefully produced illustrations. This second edition has allowed for increased clarity in presentation: the book has been divided into three sections, basic science, pathogenic mechanisms, and clinical practice. There is also inclusion of information on new and advancing areas in vascular biology including chapters on nitric oxide, apoptosis, imaging and pregnancy.
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