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The problem of obtaining permission of national governments for field research in Africa has been frequently documented. The Research Liaison Committee of the African Studies Association was formed in 1966 with the purpose of serving as a center for collection and dissemination of information on U.S. scholars and their research in Africa, communications on the role and mode of research in Africa, referral of questions it was unable to answer itself, collection of files on research clearance regulations, establishing of contact on behalf of researchers going to Africa, and maintaining liaison with African studies groups outside the United States. In interviews conducted in East Africa for the Committee in 1967, Vernon McKay learned that control procedures associated with foreign scholars in Africa were only partially security oriented. Officials, especially those in the national capitals, were being inundated by would-be researchers. Although the value of research was not denied, officials suggested to McKay that research be directed toward needs of the host country -- toward studies that would aid its economic, social, and development planning. Local officials issued a plea that research results be made available to the host as soon as possible.
Research clearance problems in Tanzania are better structured than elsewhere in Africa. Applications are directed through the University College in Dar es Salaam. In Tanzania, as in other countries, even the clearance successfully completed must be followed by establishment of contacts and working relationships “upcountry.” Field research circumstances, especially pertinent to geographers, demand the tolerance, if not the active encouragement of local (subnational) government.
Preclinical evidence suggests that diazepam enhances hippocampal γ-aminobutyric acid (GABA) signalling and normalises a psychosis-relevant cortico-limbic-striatal circuit. Hippocampal network dysconnectivity, particularly from the CA1 subfield, is evident in people at clinical high-risk for psychosis (CHR-P), representing a potential treatment target. This study aimed to forward-translate this preclinical evidence.
Methods
In this randomised, double-blind, placebo-controlled study, 18 CHR-P individuals underwent resting-state functional magnetic resonance imaging twice, once following a 5 mg dose of diazepam and once following a placebo. They were compared to 20 healthy controls (HC) who did not receive diazepam/placebo. Functional connectivity (FC) between the hippocampal CA1 subfield and the nucleus accumbens (NAc), amygdala, and ventromedial prefrontal cortex (vmPFC) was calculated. Mixed-effects models investigated the effect of group (CHR-P placebo/diazepam vs. HC) and condition (CHR-P diazepam vs. placebo) on CA1-to-region FC.
Results
In the placebo condition, CHR-P individuals showed significantly lower CA1-vmPFC (Z = 3.17, PFWE = 0.002) and CA1-NAc (Z = 2.94, PFWE = 0.005) FC compared to HC. In the diazepam condition, CA1-vmPFC FC was significantly increased (Z = 4.13, PFWE = 0.008) compared to placebo in CHR-P individuals, and both CA1-vmPFC and CA1-NAc FC were normalised to HC levels. In contrast, compared to HC, CA1-amygdala FC was significantly lower contralaterally and higher ipsilaterally in CHR-P individuals in both the placebo and diazepam conditions (lower: placebo Z = 3.46, PFWE = 0.002, diazepam Z = 3.33, PFWE = 0.003; higher: placebo Z = 4.48, PFWE < 0.001, diazepam Z = 4.22, PFWE < 0.001).
Conclusions
This study demonstrates that diazepam can partially restore hippocampal CA1 dysconnectivity in CHR-P individuals, suggesting that modulation of GABAergic function might be useful in the treatment of this clinical group.
Evidence of epigenetic risk of metabolic syndrome (MetS) from both parents, and its increasing prevalence globally, underscores the necessity for effective lifestyle interventions preconception. Despite this, very few studies have examined couples-based interventions and those which are concerned with foetal health rarely monitor paternal health outcomes(1). This study evaluates the feasibility and adherence of a 10-week couples-based lifestyle intervention targeting diet and physical activity. Utilising an exploratory sequential mixed methods design, the study recruited 16 participants (8 couples) aged 18–44 years, living together with a BMI between 18.5 and 38 kg/m². Participants received personalised dietary and physical activity guidance aligned with national guidelines, with progress tracked via the Easy Diet Diary app and the International Physical Activity Questionnaire (IPAQ). Quantitative data were collected at baseline, mid-point, and end of the intervention, while qualitative insights were obtained through semi-structured interviews post-intervention. The intervention aimed to leverage the natural support system within couples to enhance adherence to healthy lifestyle behaviours. Quantitative findings indicated positive trends in reducing sedentary behaviour by an average of 1105 minutes per week and increasing vegetable consumption by 1.7 servings per day. Participants also showed improvements in BMI and waist-to-hip ratios, with significant reductions noted by the end of the intervention. Qualitative data and thematic analysis provided rich context to these findings and underscored the importance of mutual support, shared responsibility, and accountability in fostering adherence, but also indicated a need for more flexible and user-friendly tracking tools. Partner encouragement, joint activities such as meal planning, exercising together, and shared responsibility emerged as significant adherence enhancers while differing timing and work schedules were a common barrier. This study demonstrates that a couples-based approach can effectively enhance adherence to lifestyle modifications, promoting significant behavioural changes and improving health outcomes by leveraging the inherent support system within the relationship, thereby facilitating more sustainable health behaviours. Future research should explore long-term impacts and optimise intervention strategies to address identified challenges, ensuring broader applicability and effectiveness in diverse populations. The promising results of this feasibility study advocate for the potential scalability of couples-based interventions as a public health strategy to combat MetS and related conditions.
Background: Stenotrophomonas maltophilia is an opportunistic pathogen found in healthcare settings. During April–September 2022, nine S. maltophilia bloodstream infections (BSIs) were identified among intensive care unit (ICU) patients at a hospital in Alameda County, California. Whole genome sequencing found isolates to be highly related. Despite implementation of infection prevention and control (IPC) interventions, four additional S. maltophilia BSIs were identified during June–September 2023. We investigated to identify risk factors for infection and stop transmission. Methods: We conducted a matched case-control study. A case was defined as S. maltophilia isolated from a blood culture from an ICU patient with a fever during April 2022–September 2023; control-patient subjects were patients admitted to the ICU during the same period with hospital stay greater than or equal to their matched case. Three control subjects were matched to each case. We extracted information on risk factors for infection from medical charts and observed IPC practices in hospital locations of interest. We collected environmental samples from the ICU, radiology unit, and emergency department. Results: Among 13 cases and 39 control subjects, patients exposed to iodinated contrast Omnipaque-300 (odds ratio [OR]: 5.7; 95% CI: 1.2–28.0), injectable propofol (OR: 12.2; 95% CI: 1.5–101.4), or fentanyl (OR: 9.2; 95% CI: 1.8–Inf.) were more likely to have a S. maltophilia BSI, compared with control-subjects. IPC deficiencies included improper cleaning and storage of medical equipment, including the contrast injection system, and patient care supplies. The outbreak strain of S. maltophilia was not isolated from environmental samples. Conclusions: Although a point-source was not identified, S. maltophilia was likely transmitted through improper IPC practices involving injectable contrast or anesthesia. Recommendations on proper cleaning and disinfection of the contrast injection system and proper storage, preparation, and administration of medications were made to reduce risk for contamination.
In an introductory way, and in the context of ‘embracing subjectivity,’ the claims of being ‘spiritual but not religious’ (and of its ‘pop-culture pantheism’ version) are examined in relation to their associated rejection of ‘doctrinal religion’. Both the Origenist sense of ‘seeming history’ in scripture and Vladimir Lossky’s sense of the meaning of ‘mystical theology’ are seen as relevant to exploring the importance of this rejection of doctrinal religion, especially in relation to Lossky’s focus on the way in which theology should not be seen as abstract and discursive but as essentially contemplative in nature. The relevance of divine action understandings to the concept of religious pluralism is outlined, and five theses are set out that link a naturalistic perspective on this action with the revelatory experience that is the basis of any religious tradition.
The different but overlapping notions of ‘archetypes’ in the work of Carl Jung and Mircea Eliade are outlined, and new ways of understanding the frameworks set out by them are explored in sociological terms. The relevance of ‘Platonic mysticism’ is noted in this context. Spontaneous mystical experience is also considered in this context, especially in relation to a ‘dual-process’ understanding of human cognition and Alister Hardy’s empirical research into religious experience.
How can we more deeply understand religious pluralism? In this study, Christopher C. Knight suggests that current explorations of religious pluralism may be supplemented by combining new thinking about divine action with the kind of ‘mystical theology’ that sees doctrinal statements as aids to contemplation rather than as philosophical truth claims. While Knight sees the ‘perennialist’ tradition of pluralistic thinking as deeply flawed, he nevertheless proposes that we can adopt a kind of neo-perennialism in which the supposed incompatibilities of different faith traditions may still be seen in the way that perennialists have usually considered them: as relating only to the exoteric dimension of religious faith and practice. In this way, he suggests, the perennialist notion of esoteric ecumenism may still be valid. He cautions, nevertheless, that at a methodological level, there may be defensible reasons to hesitate before adopting a full-blown pluralism of this kind.
The distinction between philosophical theology and philosophy of religion is examined in relation to the role of faith commitments in each, and the notion of doctrinal statements as ‘truth claims’ is examined in terms whether ‘natural theology’ can legitimately be pursued. It is argued that the praeambula fidei version of this pursuit is illegitimate, partly because of the way in which ‘design’ arguments have often been overturned and partly because of the kinds of theological considerations put forward by Thomas Torrance and Alister McGrath. The relevance of Thomas Kuhn’s understanding of the scientific enterprise is also noted, especially in relation to his notion of paradigms.
The relationship between the perspectives of the perennialist tradition of pluralistic thinking and the kind of apophaticism articulated in the patristic era by Gregory of Nyssa and in the modern era by Vladimir Lossky is examined, and parallels in Islamic thinking are noted. The kind of intuitive apprehension of divine realities associated with the ancient Greek concept of the nous is seen as central to this relationship. The perennialist distinction between esoteric and exoteric aspects of any faith tradition is examined in this context, and Lossky’s sense of the importance of antinomy is seen as significant for rejecting the kind of critique of pluralism that is based on the notion that the doctrinal statements of different faith traditions should be seen as philosophical ‘truth claims’.
Philosophical arguments for religious pluralism – including that of John Hick – are outlined. It is noted, however, that the question of ontology, as explored within the philosophy of science, has not been included in these arguments. The views of ontology in scientific description that are associated with the work of Karl Popper and Thomas Kuhn are outlined, but a deeper insight, it is argued, may be developed through the work of Mary Hesse and of Rom which suggests insurmountable limitations to our grasp of the ontology of created things. This understanding may be extended, it is argued, to God (or what Hick calls Reality) so that an attitude of ‘apophatic critical realism’ may be applied both to God (as it is in Eastern Orthodoxy) and to created entities. (In relation to God, something comparable can, it is noted, be found in certain Western Christian scholars such as Yves Congar.) This understanding, in its theological component, may be applied to apparent incompatibilities between different faith traditions, such as that between ‘personal’ and ‘non-personal’ and between ‘monotheistic’ and ‘polytheistic’ understandings.
The considerations outlined in earlier parts of the book are recalled in order to emphasize the importance of unconscious processes in the development of religious cognition. In this context, the importance of mythological aspects of religious texts is stressed, since the archetypal resonances of these texts – especially when reflected in liturgical usage or used in contemplative exercises – are of considerable importance in relation to noetic apprehension of the divine reality. In this context, the five theses set out in in Chapter 1 are discussed in more detail. In addition, problems of elitism and its suppression are discussed, as well as the position of those who claim to be spiritual but not religious. It is suggested that these people may, in fact, need one of the ‘doctrinal religions’ that they shun if they are to make progress on the spiritual path on which they find themselves.
In the science–theology dialogue, a ‘causal joint’ understanding of ‘special’ divine action has until recently been predominant. However, the distinction between ‘general’ and ‘special’ modes of divine action has recently been questioned in what Sarah Lane Ritchie has called a ‘theological turn’ in understandings of divine action. In the author’s own contribution to this turn, criticism of causal joint theorists’ implicit (and sometimes explicit) assumption of a temporal God is criticized, as is the failure to apply apophatic perspectives to the notion of God’s ‘personal’ nature. In addition, an argument from human providential action is seen as significant for developing a ‘fixed instructions’ model of divine action, in which teleology is regarded as important (though not in a way that challenges scientific perspectives). What is effectively a ‘single act’ model of divine action is thus defended, but of a different kind to that which is usually understood when this term is used.
‘Strong’ theistic naturalism is advocated, so that the notion of ‘special’ divine action is rendered redundant while scientism and a ‘God of the gaps’ notion of God’s action are avoided. A version of this kind of naturalism can affirm miraculous events in the way that Augustine of Hippo seems to have envisaged, which may now be interpreted as analogous to the scientist’s notion of regime change. In this context, some of the insights of evolutionary psychology become important, especially in relation to the evolution of human religiosity, which has significant implications for developing religious pluralism.
The notion of noetic perception may be expanded in relation to the role of the imagination in revelatory experience. Here, the expansion of neo-Platonic perspectives in the understanding of Samuel Taylor Coleridge is significant, as are the notion of the imaginal developed by Henry Corbin and the understanding of the role of the human imaginative faculty in religious visionary experience, as explored by Karl Rahner and Hans Urs von Balthasar. This kind of analysis has implications for solving certain puzzles inherent in the New Testament accounts of visions of the risen Christ. However, questions arise in relation to this understanding, and these may be tackled in part through recent Christian thinking about the notion of revelation, in which the focus is no longer on ‘information about God’ but on what Yves Congar has called an orientation towards salvation. This suggests an understanding akin to the perennialist separation of exoteric and esoteric aspects of religious traditions in the sense of suggesting a two-component, psychological-referential model of revelatory experience.
The distortions of Augustinian and Calvinist approaches to natural theology are noted, and the different approach of Eastern Orthodoxy is examined, especially in relation to the notion of noetic perception in the approach of Gregory of Nyssa and to its application to the contemplation of nature as understood by Maximus the Confessor. More purely ‘philosophical’ considerations are also examined, especially in relation to the ‘weight’ that is assigned to competing arguments. In this context, the concept of noetic perception is applied to the notion of ‘baptized reason’. It is suggested that in relation to the praeambula fidei approach of Thomas Aquinas, even scholastic versions of natural theology may need revision because of nuances in that work that are often unrecognized.
It is suggested that current religious studies are distorted by what sociologists sometimes call recipe knowledge, especially in relation to the common assumption – still partially valid – that religion should no longer be seen in essentialist or perennialist terms. The possibility of neo-perennialism is explored. Widespread assumptions about projecting onto faith traditions ‘essentialist’ understandings are critiqued, particularly in relation to Buddhism, and common assumptions about the inapplicability of terms such as religion and myth are questioned. In this context, evolutionary perspectives are important because ‘dual process’ notions of human cognition may be applied to the historical development of human religiosity. This means that a revived recognition of a universal aspect of human religiosity is necessary, based not on very questionable anthropological speculations of the kind that became common in the late-nineteenth and early-twentieth centuries but on current exploration of brain functioning and of its evolutionary development.