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202 results

Page 1 of 11

  • The impact of whey protein on plasma branched-chain amino acids and glycaemic control in humans. A narrative review

  • Hannah L. Bell, Kim G. Jackson, Les A. Crompton, David I. Givens, Julie A. Lovegrove
  • Journal:
    Nutrition Research Reviews / Accepted manuscript
    Published online by Cambridge University Press:
    10 July 2025, pp. 1-35
    • Article
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  • Impaired glycaemic control is a major risk factor for developing type 2 diabetes (T2D), a worldwide health epidemic intrinsically linked to diet and obesity. Whey proteins (WP) are increasingly popular supplements that are a rich source of branched-chain amino acids (BCAA), essential for muscle protein synthesis and metabolic regulation. In humans, fasting plasma concentrations of BCAA are maintained around 350 µM but become chronically elevated by 10-25% in persons with T2D. Little is known about whether BCAA from WP impacts circulating BCAA concentrations and contributes to this phenomenon. This narrative review used a systematic search approach with relevant keywords to identify evidence from randomised controlled trials in normoglycaemic humans and those with insulin resistance or T2D, on the effects of WP intake on plasma BCAA and glycaemic control. This review is, to the authors’ knowledge, the first to specifically examine the effects of WP intake on plasma BCAA concentrations in relation to glycaemic control. Whilst the majority of acute studies identified (n=6) reported that WP consumption between 10 to 50 g significantly elevates postprandial BCAA and insulin responses (as evidenced by peak concentration and/or area under the curve), evidence from chronic studies (n=3) report inconsistent findings on the impact of 9 to 51g of WP per day on fasting BCAA and glycaemic control (e.g., fasting glucose and insulin, insulin clearance). Findings from this literature review highlight the need for further studies that investigate the relationship between WP consumption with BCAA and glycaemic control, and to determine underlying mechanisms of action.

Principles of Medicine in Africa
  • 5th edition
  • Edited by David Mabey, Martin W. Weber, Moffat Nyirenda, Dorothy Yeboah-Manu, Jackson Orem, Laura Benjamin, Michael Marks, Nicholas A. Feasey
  • Published online:
    18 June 2025
    Print publication:
    05 June 2025
  • Principles of Medicine in Africa combines clinical medicine with a rich understanding of the major environmental and cultural influences on health and disease, providing comprehensive guidance for anyone intending to practise medicine in Africa. Presenting disease in the context of family and culture, the effects of inequality and problems of limited resources are addressed. The authors have a wealth of experience in front line healthcare in Africa and provide practical, evidence-based management guidelines for all the common and less common conditions likely to be encountered. This fifth edition has been thoroughly updated to incorporate the latest research findings and management guidelines and there has been much greater involvement of African physicians in the writing and editorial process. The chapters on cancer and non-communicable diseases have been expanded and new chapters have been added on digital health, critical care in a resource-limited setting, antimicrobial resistance, COVID-19 and other emerging infectious diseases.

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