Neuromuscular disorders (NMDs) are a heterogeneous group of conditions characterized by progressive muscle weakness, motor impairment and risk of malnutrition, affecting the quality of life (QoL) of patients. While pharmacological treatments are essential for the management of symptoms, the role of diet, nutrition and other lifestyle factors remains underexplored. This narrative systematic review, performed on PubMed, Web of Science, and Scopus following PRISMA guidelines, aimed to investigate the relationship between lifestyle, the progression of NMDs and the QoL. A total of 30 studies (n=5055 patients) met inclusion criteria. According to our search strategy, the most representative lifestyle factors were diet (70%), physical activity (53.3%) and emotional perception and care (36.7%); 7 papers (23.3%) evaluated three or more lifestyle aspects. Overall, both quantitative and qualitative deficiencies emerged: calories, proteins, lipids and fibres, as well as vitamin C, vitamin E, zinc, selenium and calcium were lower than recommended. A reduced consumption of fruits, vegetables, legumes, nuts and seeds, replaced by ultra-processed foods, was detected. Diets optimised for calorie and nutrients intake, rich in anti-inflammatory foods, have shown benefits both in mitigating oxidative stress and muscle degeneration. Regarding other aspects of lifestyle, although physical activity was associated with improved motor performance and QoL, adherence was low, particularly among females. Negative emotional status emerged as a critical factor influencing patients’ overall well-being. Even in the most complex neuromuscular disease settings, addressing nutrition and dietary habits, in the context of lifestyle, could support patients and their families throughout the disease course and improve their QoL.

Sarcopenia is a progressive skeletal muscle disorder characterized by the loss of muscle mass and strength. The concept of pro-anabolic modulators (including vitamin D, leucine, omega-3 fatty acids, and probiotics) as nutritional agents to counteract sarcopenia has been introduced as a promising strategy to restore anabolic balance in aging muscle. This systematic review aimed to synthesize recent evidence on the effectiveness of these compounds on muscle mass and physical performance. A total of 53 randomized controlled trials were included: 30 evaluated vitamin D, 8 leucine, 9 omega-3, and 6 probiotics. Across studies, although results for vitamin D were heterogeneous, daily supplementation suggested a more consistent potential for beneficial effects compared to bolus regimens, particularly when co-administered with other agents or physical exercise. Leucine demonstrated greater efficacy when combined with resistance training or other pro-anabolic agents. Most studies on omega-3 fatty acids reported improvements in muscle strength and functional outcomes, especially in long-duration interventions. Probiotics also showed promising results, with almost all studies reporting positive effects on muscle mass and strength, despite variability in strains and protocols. Given the low to very low certainty of evidence for most outcomes (except for physical performance, which reached moderate certainty), these results should be interpreted with caution, despite a general trend toward favorable outcomes. These findings suggest that combining pro-anabolic modulators (or pairing them with exercise or additional nutrients) may enhance their efficacy on muscle-related outcomes. Further research is warranted to define optimal protocols and to clarify the mechanisms underlying their potential synergistic effects.

Malnourished infants u6m are a vulnerable but not enough-prioritized group, with low consolidated evidence to guide outpatient and community-based care. This study synthesized evidence on outpatient and community-based management of malnourished infants u6m, focusing on intervention strategies, outcomes, barriers, and policy implications. Following the JBI framework and PRISMA guidelines, this review included information about the outpatient or community-based management of malnourished infants u6m or mother–infant dyads, published in English between 2007 and 2025. Four databases and multiple institutional websites were searched, supplemented by grey literature. Data were extracted on various study features, interventions, and outcomes. Total 26 studies were included, only five published after the new 2023 WHO guideline. Evidence was concentrated in sub-Saharan Africa and South Asia. Several included studies described outpatient care as feasible and acceptable in multiple contexts, with reported recovery rates ranging from 65% to 91%; however, methodological heterogeneity limits comparability across studies. Breastfeeding support, maternal health, and culturally adapted interventions were described as important indicators. Tools such as MAMI clinical care pathway, MUAC and the MAMI WAZ look-up chart were described as effective but require further validation and contextual testing. Major barriers mentioned shortages of trained staff, inconsistent protocols, and policy reluctance to scale outpatient models. Outpatient and community-based care for malnourished infants u6m aligns with recent WHO guidance on managing ‘at-risk’ infants. However, widespread adoption requires stronger evidence-based management or tools, integration into health systems, and national policies. Strengthening research and programmatic consensus will be essential to improve outcomes for this vulnerable population.

College students (those enrolled in two- and four-year postsecondary institutions) with caregiving responsibilities for children or other dependents face unique challenges balancing academic and caregiving duties. This scoping review aimed to describe the prevalence of food insecurity among United States college student caregivers and their experiences with food insecurity, dietary quality/intake, academic outcomes, and food security programming. A search of peer-reviewed and grey literature was conducted in four databases: CINAHL, GOOGLE SCHOLAR, EMBASE, and MEDLINE. Identified articles were evaluated against inclusion criteria. Of 162 articles identified, 61 articles met eligibility criteria and underwent data extraction and descriptive analysis. Forty-two articles (69%) reported the prevalence of food insecurity among college student caregivers, with prevalence ranging from 9-79%. Single parents, students of color, LGBTQ+ individuals, and those with multiple dependents had increased food insecurity risk. Thirteen studies examined dietary patterns, finding caregiving students prioritized feeding their children, reduced their own meal sizes, and chose low-cost, low-nutrient foods due to budget constraints. Academic challenges included difficulties in time management and scheduling stress. No studies examined GPA or academic performance. Thirteen studies identified the use of food assistance programs. Food assistance programs were underutilized due to limitations like restricted pantry hours and availability. Housing insecurity frequently co-occurred with food insecurity. Food insecurity disproportionately affects college student caregivers compared to non-caregiving students. Comprehensive programming is needed to support food and nutrition security, including connections to government and university food assistance programs, childcare services, and program modifications to reduce barriers to academic success for caregiving students.