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Hepatic and splenic venous access are specialised techniques used to perform diagnostic and interventional procedures in the cardiac catheterisation laboratory. Bleeding events are the most commonly reported complication following hepatic or splenic venous access. The VASCADE Vascular Closure System (Cardiva Medical Inc. Santa Barbara, CA) is an approved device for closure of femoral vascular access tracts in patients ≥18 years of age. We report our experience using VASCADE to close the hepatic or splenic venous access site in the cardiac catheterisation laboratory.
Methods:
This is a single centre retrospective review of all patients who had percutaneous hepatic or splenic venous access obtained in the cardiac catheterisation laboratory from March 1, 2022 through October 30, 2023 and underwent tract closure with VASCADE.
Results:
Ten patients (six male) underwent 16 procedures (median age and weight 3.5 years and 12.5 kg) with 15 hepatic and two splenic veins accessed. Successful closure of the access tracts with VASCADE was performed in all patients. There were no major adverse events related to closure of the access sites with VASCADE.
Conclusion:
VASCADE can be used following transhepatic and trans-splenic venous access in the cardiac catheterisation laboratory to safely close the access tract and potentially reduce the risk of post-procedural bleeding complications. Further evaluation in a larger cohort of patients is needed to ensure VASCADE is safe for use and provides adequate haemostasis following hepatic or splenic venous access, particularly in children.
In 2020, an outbreak of Salmonella Hadar illnesses was linked to contact with non-commercial, privately owned (backyard) poultry including live chickens, turkeys, and ducks, resulting in 848 illnesses. From late 2020 to 2021, this Salmonella Hadar strain caused an outbreak that was linked to ground turkey consumption. Core genome multilocus sequence typing (cgMLST) analysis determined that the Salmonella Hadar isolates detected during the outbreak linked to backyard poultry and the outbreak linked to ground turkey were closely related genetically (within 0–16 alleles). Epidemiological and traceback investigations were unable to determine how Salmonella Hadar detected in backyard poultry and ground turkey were linked, despite this genetic relatedness. Enhanced molecular characterization methods, such as analysis of the pangenome of Salmonella isolates, might be necessary to understand the relationship between these two outbreaks. Similarly, enhanced data collection during outbreak investigations and further research could potentially aid in determining whether these transmission vehicles are truly linked by a common source and what reservoirs exist across the poultry industries that allow Salmonella Hadar to persist. Further work combining epidemiological data collection, more detailed traceback information, and genomic analysis tools will be important for monitoring and investigating future enteric disease outbreaks.
Partial anomalous venous connection with sinus venosus atrial septal defect is repaired with different approaches including the Warden procedure. Complications include stenosis of the superior caval vein and pulmonary venous baffle; however, cyanosis is rarely seen post-operatively. We report a patient presenting with cyanosis 5 years after a Warden, which was treated with a transcatheter approach.
Sudden sensorineural hearing loss is considered idiopathic in up to 90 per cent of cases. This study explored the role of blood tests as biomarkers for the diagnosis and prognosis of sudden sensorineural hearing loss.
Method
Two researchers filtered 34 papers into the final review. This review was pre-registered on the Prospero database and conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.
Results
Raised inflammatory markers are almost universal in sudden sensorineural hearing loss, suggesting an inflammatory or autoimmune process. The most useful biomarkers are neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and fibrinogen level. Focused investigations should be deployed on a case-by-case basis to identify underlying metabolic, infective and autoimmune conditions.
Conclusion
A full blood count and coagulation screen (fibrinogen) is recommended in all cases of sudden sensorineural hearing loss. These are inexpensive, accessible and offer as much diagnostic and prognostic information as any other biomarker. There is emerging evidence regarding specific biomarkers for sudden sensorineural hearing loss prognosis, with heat shock protein-70, anti-endothelial cell antibody and prestin demonstrating potential; investigation of their validity through prospective, controlled research is recommended.
Cochlear implantation performed under local anaesthesia is an increasingly accepted technique worldwide, though the literature to date includes only single-surgeon and single-centre experiences. This study explored the national experience of UK surgeons using this challenging surgical technique, with the goal of providing consensus recommendations.
Methods
A qualitative analysis was conducted of semi-structured interviews with 10 UK-based cochlear implantation surgeons, focusing on common challenges, how to overcome them and candidate selection.
Results
Cochlear implantation under local anaesthesia can potentially be offered to all eligible adult patients with favourable anatomy. A posterior tympanotomy and round window approach is recommended. Common challenges and recommendations are explored thematically: managing patient, surgeon and staff expectations; optimising communication; patient comfort and position; minimising pain and vertigo; and safe use of sedation.
Conclusion
This is the first study of national experience of cochlear implantation performed under local anaesthesia. Key themes, including refinements to surgical technique and optimising patient comfort and communication, have been explored in depth.
A key clinical feature of necrotising otitis externa is granulation tissue arising from the ear canal, representing epidermal compromise. The aim of this work was to explore the role of epidermal compromise in the aetiology of necrotising otitis externa.
Method
A structured risk factor history was taken from 54 patients diagnosed with necrotising otitis externa between 2017 and 2022. Primary care records were also reviewed.
Results
A total of 94 per cent of patients reported incidents of potential epidermal compromise preceding severe pain onset, including a 35 per cent incidence of ear syringing. A total of 94 per cent of patients were immunosuppressed, including 78 per cent with diabetes. All patients had medical co-morbidities.
Conclusion
This study proposed an aetiological triad for necrotising otitis externa: immunosuppression, infection and epidermal compromise. Epidermal compromise is a potentially modifiable risk factor for necrotising otitis externa. Meticulous primary ear care for older adult, diabetic and immunosuppressed patients is recommended. These populations should never undergo ear syringing and should avoid ear canal trauma and prolonged exposure to moisture.
Autism spectrum disorder is a lifelong neurodevelopmental condition encompassing complex physical and neurological symptoms, including complex sensory symptoms. This review explores the interface between autism spectrum disorder and paediatric ENT.
Methods
Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (‘PRISMA’) guideline, a robust literature search and review was conducted by two researchers. Thirty-four papers were filtered into the final review.
Results
Published literature clearly demonstrates potential for autism spectrum disorder to present in the form of auditory and other sensory symptoms to ENT surgeons and audiologists who may not fully appreciate this complex condition. Despite this well-documented link, auditory symptoms, auditory processing disorders and hearing loss within autism spectrum disorder remain poorly understood.
Conclusion
Improved recognition and understanding of autism spectrum disorder by otolaryngologists could enable more effective diagnostic and management strategies for autistic children who present with auditory and other sensory symptoms. In light of the current ‘autism epidemic,’ there is an urgent need for further research on this theme.
Mentoring within surgery is increasingly recognised as a powerful development tool, but participant expectations have not previously been explored. This study aimed to explore and analyse participant expectations from the UK's first national otolaryngology mentorship programme.
Method
Participants completed open-ended questionnaires. Responses were qualitatively analysed using a grounded theory approach. Iterative cycles were used to develop codes using a constant comparison technique. Emerging categories were refined to identify core themes.
Results
Key mentee expectations were career, and clinical and academic guidance. Enhancing networking opportunities was highlighted by medical students and junior trainees. Psychosocial and lifestyle support were predominant themes for all trainees. Receiving impartial advice and guidance from outside their training region was expressed only by senior trainees. Mentor expectations aligned with those of mentees.
Conclusion
This study identified key areas of the ‘hidden curriculum’ for students and trainees in otolaryngology, showing the evolving expectations and priorities as they progress through training.
Necrotising otitis externa is a serious infective condition. Patients are typically frail, diagnostic delay is common and severe pain is a key feature. This study aimed to qualitatively analyse patient-centred data to identify key themes in the patient's experience.
Methods
Open-ended questionnaires were sent to 28 patients. Responses were qualitatively analysed using a grounded theory approach. Iterative cycles were used to develop codes using a constant comparison technique. Emerging categories were refined to identify core themes.
Results
Four main themes emerged: severe pain, mental health, quality of life and diagnostic delays.
Conclusion
This is the first study to explore patients’ perspectives in necrotising otitis externa. It indicates a need to raise awareness of necrotising otitis externa, and to improve symptom management, pain control and quality of life. This valuable information can be used to identify research priorities, guide service improvements, improve clinical care and feed into the development of a Core Outcome Set for necrotising otitis externa.
The aim of this study was to develop a novel live Delphi method to obtain a consensus on the skills and competencies that a new ENT registrar (specialty trainee level 3) should possess. Developing a clear outcome set for core surgical trainees is important so that this phase of training can be directed at specific aims.
Method
Attendees at the North of England meeting participated in this Delphi exercise. Participants comprised a range of ENT professionals from medical student to consultant surgeons. The main outcome measure of consensus was defined prior to the study as the median response value: strongly agree or more for positive consensus and strongly disagree or less for negative consensus.
Results
This study identified multiple areas that reached consensus relating to elective and operative skills and demonstrated agreement in areas relating to ENT specific and allied specialty experience.
Conclusion
This study has highlighted a novel method for shaping surgical curricula.
Necrotising otitis externa is a severe, life-threatening infection. Epidemiological data demonstrate a dramatic rise in reported cases in England from 2002 to 2017. The reasons for this remain elusive.
Methods
A quantitative descriptive study was undertaken using epidemiological data from the Hospital Episode Statistics database. Cases from 2002 to 2017 were compiled and analysed. Four potential theories were explored to explain the rise in incidence.
Results
Within the 16-year period, 7327 necrotising otitis externa cases were reported. Annual necrotising otitis externa incidence increased 1142 per cent within the 16-year period, from 123 recorded cases in 2002 to 1405 cases in 2017. This correlates with an increasing prevalence of diabetes, an ageing population and likely increased physician awareness of necrotising otitis externa. There is insufficient evidence to support antibiotic resistance as a significant associated factor.
Conclusion
Correlation does not imply causation. It is likely that a combination of factors is contributing to the rise in necrotising otitis externa incidence, including increased physician recognition, diagnosis and accurate clinical coding.
Necrotising otitis externa is an invasive, infective condition, with minimal evidence underpinning its diagnosis and management. This work aimed to analyse literature from the past decade, to identify emerging themes and important topics for future research.
Methods
A robust literature search and review were conducted by two researchers. Sixty studies were filtered into the final review. A grounded theory approach was used to identify core themes. Data within these themes formed the basis of the review.
Results
There is no consensus regarding a clinical definition or outcome measures of necrotising otitis externa, and there exists no level 1, 2 or 3 evidence to diagnose, investigate, monitor or treat necrotising otitis externa. Emerging themes in the literature direct researchers to important topics for future clinical trials, including risk factors, microbiological culture, management strategies and radiology.
Conclusion
In order to optimise understanding and management of necrotising otitis externa, future research requires robust clinical trials and consistently reported outcome measures.
This study aimed to explore the impact of the coronavirus disease 2019 pandemic and postponement of elective surgical procedures for profoundly deaf patients awaiting cochlear implantation.
Method
Open-ended questionnaires were sent to all adult patients awaiting cochlear implantation surgery. Qualitative analysis was performed using a grounded theory approach.
Results
Participants described a primarily negative impact on wellbeing from the surgery delay, expressing feelings of isolation or loneliness. Low mood, depression or hopelessness were commonly expressed by elderly participants; frustration and anxiety were described by young adults. Participants described a negative impact on their general daily life, describing difficulties communicating with facemasks and struggles with reliance on telephone communication because of social distancing. Despite these significant psychosocial challenges, only a minority described adaptive coping strategies.
Discussion
Profoundly deaf patients may be at greater psychosocial risk because of unique challenges from their hearing disability. Our findings can be used to develop evidence-driven strategies to improve communication, wellbeing and quality of life.
Coronavirus disease 2019 has transformed medical education worldwide. Innovations in ENT teaching for medical students have focused on virtual learning, often replacing history-taking, patient examination and practical procedure observation. This qualitative study aimed to evaluate student experience and the impact of the altered learning environment.
Methods
Open-ended questionnaires were sent to students following ENT placements from March 2020 to March 2021. Responses were qualitatively analysed and coded using a grounded theory approach. Iterative cycles were used to develop codes via a constant comparison technique. Emerging categories from codes were refined to identify core themes.
Results
Core themes were explored, including: reduced clinical experience and patient contact compared with student expectations; challenges to learning opportunities in ENT; and the experience of different teaching methods, or preference for face-to-face teaching.
Conclusion
Medical students on ENT placement have expectations of patient contact for learning opportunities. ENT departments should ensure that patient contact and face-to-face learning opportunities are facilitated, while maintaining safety, including appropriate personal protective equipment provision.
POST control of cowpea in cotton was evaluated in 1990 and 1991. Early POST-directed (EPD) application of fluometuron + MSMA provided 89% cowpea control 2 wk after treatment. Cowpea control 4 wk after the early treatments was similar with fluometuron + MSMA EPD and sequential directed applications of MSMA followed by (fb) MSMA, methazole + MSMA fb cyanazine + MSMA, and fluometuron + MSMA fb cyanazine + MSMA. The average reduction in cowpea biomass 12 wk after planting with these treatments was 93%. MSMA fb MSMA POST-directed was the only treatment with a lint cotton yield similar to that of weed-free cotton. Lint cotton yields with fluometuron + MSMA, methazole + MSMA fb cyanazine + MSMA, and fluometuron + MSMA fb cyanazine + MSMA were similar to those obtained with MSMA fb MSMA.
Field studies were conducted in 1991 to 1993 to determine the effects of PRE and POST herbicides alone and in factorial combinations on sicklepod control, weed biomass, and soybean seed yields. Herbicides evaluated were metribuzin PRE, metribuzin + chlorimuron PRE, imazaquin PRE and POST, chlorimuron POST, and AC 263,222 POST POST herbicides alone provided better sicklepod control than PRE herbicides alone. However, sequential (SEQ) treatments [PRE followed by (fb) POST] provided better sicklepod control than single herbicide treatments. Metribuzin and metribuzin + chlorimuron alone or used in a SEQ program provided similar PRE control of sicklepod, and both controlled sicklepod better than imazaquin in 1991 and 1992. Chlorimuron alone or in a SEQ program provided better POST control than AC 263,222 or imazaquin alone when soil moisture levels at planting favored weed seed germination. When soil moisture levels at planting were unfavorable for weed seed germination, the residual activity of imazaquin provided the best season-long control. SEQ herbicide applications allowed soybean to attain higher seed yields than single (PRE or POST) herbicide treatments all 3 yr. However, only metribuzin fb chlorimuron in 1991 and 1992 and imazaquin fb imazaquin and imazaquin fb chlorimuron in 1993 allowed soybean to achieve seed yields similar to weed-free soybean. Soybean seed yields were greater with POST than with PRE herbicides 2 of 3 yr, but no single herbicide treatment provided soybean seed yields similar to weed-free soybean.
Field experiments were established to evaluate coffee senna control in cotton with registered PRE, early POST-directed (EPD), and late POST-directed (LPD) herbicides and with pyrithiobac applied PRE and early POST. Fluometuron and norflurazon applied PRE controlled coffee senna 87 and 65%, respectively, 6 wk after planting (WAP). Methazole applied EPD controlled coffee senna 96% 2 wk after application, whereas fluometuron and MSMA applied EPD controlled 70 and 16%, respectively. LPD applications of cyanazine, diuron, and prometryn averaged only 45% control 8 WAP. MSMA applied LPD controlled coffee senna only 12%. Fluometuron and norflurazon applied PRE followed by methazole applied EPD and cyanazine applied LPD controlled coffee senna 98 and 99% 6 WAP, respectively. PRE, early POST, and PRE followed by early POST applications of pyrithiobac controlled coffee senna 88, 89, and 95% 6 WAP, respectively. Seed cotton yields were similar to weed-free cotton with all treatments except MSMA applied EPD and the LPD treatments, all of which provided unacceptable (12 to 49%) control 8 WAP.
Field studies were conducted in 1993 and 1994 to evaluate sicklepod control with combinations of imazaquin + metribuzin at lower than normal use rates. Soybean was seeded in late-May to early-June each year and imazaquin and metribuzin were applied PPI alone at 0.75 and 1x and 0.5, 0.75, and 1x their registered rates, respectively, and in factorial combinations of their 0.5 and 0.75x rates. The registered (1x) rates for imazaquin and metribuzin on this soil type are 0.14 and 0.43 kg/ha, respectively. Several standard sequential treatments and flumetsulam + trifluralin PPI at 0.06 + 0.70 and 0.07 + 0.95 kg/ha were included for comparison. Sicklepod control and soybean seed yield responses differed between 1993 and 1994. In 1993, the combinations of imazaquin + metribuzin averaged 90% control 6 wk after planting (WAP) and soybean seed yield increased 75% compared to the untreated check. Imazaquin + metribuzin at their respective 0.5x rate was as effective as any treatment evaluated. In 1994, sicklepod control was generally lower with all treatments. Soybean seed yield was reduced due to sicklepod interference with soil-applied treatments alone. However, imazaquin + metribuzin at their respective 0.75x rate provided sicklepod control levels and reductions in weed biomass similar to those observed with flumetsulam + trifluralin at 0.07 + 0.95 kg/ha and the sequential treatments, and increased soybean seed yield 19% compared to the untreated check.
Recently, three-dimensional printing of heart models is being used to plan percutaneous and surgical interventions in patients with CHD. We describe a case where we used a three-dimensional print model to plan a complex percutaneous intervention in a patient with coarctation of the aorta.