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Functional impairment in daily activities, such as work and socializing, is part of the diagnostic criteria for major depressive disorder and most anxiety disorders. Despite evidence that symptom severity and functional impairment are partially distinct, functional impairment is often overlooked. To assess whether functional impairment captures diagnostically relevant genetic liability beyond that of symptoms, we aimed to estimate the heritability of, and genetic correlations between, key measures of current depression symptoms, anxiety symptoms, and functional impairment.
Methods
In 17,130 individuals with lifetime depression or anxiety from the Genetic Links to Anxiety and Depression (GLAD) Study, we analyzed total scores from the Patient Health Questionnaire-9 (depression symptoms), Generalized Anxiety Disorder-7 (anxiety symptoms), and Work and Social Adjustment Scale (functional impairment). Genome-wide association analyses were performed with REGENIE. Heritability was estimated using GCTA-GREML and genetic correlations with bivariate-GREML.
Results
The phenotypic correlations were moderate across the three measures (Pearson’s r = 0.50–0.69). All three scales were found to be under low but significant genetic influence (single-nucleotide polymorphism-based heritability [h2SNP] = 0.11–0.19) with high genetic correlations between them (rg = 0.79–0.87).
Conclusions
Among individuals with lifetime depression or anxiety from the GLAD Study, the genetic variants that underlie symptom severity largely overlap with those influencing functional impairment. This suggests that self-reported functional impairment, while clinically relevant for diagnosis and treatment outcomes, does not reflect substantial additional genetic liability beyond that captured by symptom-based measures of depression or anxiety.
We assessed healthcare workers’ knowledge, attitudes, and practices around disposable personal protective equipment (PPE) use. We observed that healthcare workers are interested in sustainable policies and identified areas for policy changes to reduce PPE waste.
Channel coding lies at the heart of digital communication and data storage. Fully updated, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This new edition includes over 50 new end-of-chapter problems and new figures and worked examples throughout. The authors emphasize the practical approach and present clear information on modern channel codes, including turbo and low-density parity-check (LDPC) codes, detailed coverage of BCH codes, Reed-Solomon codes, convolutional codes, finite geometry codes, product codes as well as polar codes for error correction and detection, providing a one-stop resource for classical and modern coding techniques. Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then extend to advanced topics such as code ensemble performance analyses and algebraic code design.
Increasing daylight exposure might be a simple way to improve mental health. However, little is known about daylight-symptom associations in depressive disorders.
Methods
In a subset of the Australian Genetics of Depression Study (N = 13,480; 75% female), we explored associations between self-reported number of hours spent in daylight on a typical workday and free day and seven symptom dimensions: depressive (overall, somatic, psychological); hypo-manic-like; psychotic-like; insomnia; and daytime sleepiness. Polygenic scores for major depressive disorder (MDD); bipolar disorder (BD); and schizophrenia (SCZ) were calculated. Models were adjusted for age, sex, shift work status, employment status, season, and educational attainment. Exploratory analyses examined age-stratified associations (18–24 years; 25–34 years; 35–64 years; 65 and older). Bonferroni-corrected associations (p < 0.004) are discussed.
Results
Adults with depression reported spending a median of one hour in daylight on workdays and three hours on free days. More daylight exposure on workdays and free days was associated with lower depressive (overall, psychological, somatic) and insomnia symptoms (p’s<0.001), but higher hypo-manic-like symptoms (p’s<0.002). Genetic loading for MDD and SCZ were associated with less daylight exposure in unadjusted correlational analyses (effect sizes were not meaningful). Exploratory analyses revealed age-related heterogeneity. Among 18–24-year-olds, no symptom dimensions were associated with daylight. By contrast, for the older age groups, there was a pattern of more daylight exposure and lower insomnia symptoms (p < 0.003) (except for 25–34-year-olds on free days, p = 0.019); and lower depressive symptoms with more daylight on free days, and to some extent workdays (depending on the age-group).
Conclusions
Exploration of the causal status of daylight in depression is warranted.
This paper explores some of the problems associated with traditional canonical correlation. A response surface methodology is developed to examine the stability of the derived linear functions, where one wishes to investigate how much the coefficients can change and still be in an ɛ-neighborhood of the globally optimum canonical correlation value. In addition, a discrete (or constrained) canonical correlation method is formulated where the derived coefficients of these linear functions are constrained to be in some small set, e.g., {1, 0, −1}, to aid in the interpretation of the results. An example concerning the psychographic responses of Wharton MBA students of the University of Pennsylvania regarding driving preferences and life-style considerations is provided.
Diagnostic stewardship of urine cultures from patients with indwelling urinary catheters may improve diagnostic specificity and clinical relevance of the test, but risk of patient harm is uncertain.
Methods:
We retrospectively evaluated the impact of a computerized clinical decision support tool to promote institutional appropriateness criteria (neutropenia, kidney transplant, recent urologic surgery, or radiologic evidence of urinary tract obstruction) for urine cultures from patients with an indwelling urinary catheter. The primary outcome was a change in catheter-associated urinary tract infection (CAUTI) rate from baseline (34 mo) to intervention period (30 mo, including a 2-mo wash-in period). We analyzed patient-level outcomes and adverse events.
Results:
Adjusted CAUTI rate decreased from 1.203 to 0.75 per 1,000 catheter-days (P = 0.52). Of 598 patients triggering decision support, 284 (47.5%) urine cultures were collected in agreement with institutional criteria and 314 (52.5%) were averted. Of 314 patients whose urine cultures were averted, 2 had a subsequent urine culture within 7 days that resulted in a change in antimicrobial therapy and 2 had diagnosis of bacteremia with suspected urinary source, but there were no delays in effective treatment.
Conclusion:
A diagnostic stewardship intervention was associated with an approximately 50% decrease in urine culture testing for inpatients with a urinary catheter. However, the overall CAUTI rate did not decrease significantly. Adverse outcomes were rare and minor among patients who had a urine culture averted. Diagnostic stewardship may be safe and effective as part of a multimodal program to reduce unnecessary urine cultures among patients with indwelling urinary catheters.
Evidence-based insertion and maintenance bundles are effective in reducing the incidence of central line-associated bloodstream infections (CLABSI) in intensive care unit (ICU) settings. We studied the adoption and compliance of CLABSI prevention bundle programs and CLABSI rates in ICUs in a large network of acute care hospitals across Canada.
Achieving equitable healthcare access is a global challenge. Improving whole-population mental health and reducing the global burden of mental disorders is a key recommendation of the 2018 Lancet Global Mental Health Commission, which proposed monitoring national indicators, including the proportion of people with severe mental disorders who are service-users. This study aims to derive an equity indicator from national datasets integrating need, service utilisation and socioeconomic status, and demonstrate its utility in identifying gaps in mental health service use amongst those with the greatest need, thereby guiding equitable healthcare delivery.
Methods
We present a case study of a universal health insurance scheme (Medicare) in Australia. We developed the equity indicator using three national datasets. Geographic areas were linked to an area-based socioeconomic deprivation quintile (Census 2016). Per geographic area, we estimated the number with a mental healthcare need using scores ≥30 on the Kessler-10 (Australian National Health Surveys 2015 and 2018), and obtained the number of services used, defined as mental health-related contacts with general practitioners and mental health professionals (Medicare administrative data 2015–2019). We divided the number of services by the population with an estimated mental healthcare need and averaged these use-rates across each socioeconomic deprivation quintile. The equity indicator is the ratio of the use-rates in the least versus most deprived quintiles.
Results
Those estimated to have the greatest need for mental healthcare in 2019 ranged between 8.2% in the most disadvantaged area quintile (Q1) and 2.4% in the least (Q5), corresponding to a proportional increase of 27.7% in Q1 and 19.5% in Q5 since 2015. Equity-indicator-adjusted service rates of 4.2 (3.8–4.6) and 23.9 (22.4–25.4) showed that individuals with the highest need for care residing in Q1 areas received a stark 6 times fewer services compared to their Q5 counterparts, producing an equity indicator of 6.
Conclusions
As the global prevalence of common mental disorders may be increasing, it is crucial to calculate robust indicators evaluating the equity of mental health service use. In this Australian case study, we developed an equity indicator enabling the direct comparison of geographic areas with different need profiles. The results revealed striking inequities that persisted despite publicly-funded universal healthcare, recent service reforms and being a high-income country. This study demonstrates the importance and feasibility of generating such an indicator to inform and empower communities, healthcare providers and policymakers to pursue equitable service provision.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.
Channel coding lies at the heart of digital communication and data storage. Fully updated to include current innovations in the field, including a new chapter on polar codes, this detailed introduction describes the core theory of channel coding, decoding algorithms, implementation details, and performance analyses. This edition includes over 50 new end-of-chapter problems to challenge students and numerous new figures and examples throughout.
The authors emphasize a practical approach and clearly present information on modern channel codes, including polar, turbo, and low-density parity-check (LDPC) codes, as well as detailed coverage of BCH codes, Reed–Solomon codes, convolutional codes, finite geometry codes, and product codes for error correction, providing a one-stop resource for both classical and modern coding techniques.
Assuming no prior knowledge in the field of channel coding, the opening chapters begin with basic theory to introduce newcomers to the subject. Later chapters then begin with classical codes, continue with modern codes, and extend to advanced topics such as code ensemble performance analyses and algebraic LDPC code design.
300 varied and stimulating end-of-chapter problems test and enhance learning, making this an essential resource for students and practitioners alike.
Provides a one-stop resource for both classical and modern coding techniques.
Starts with the basic theory before moving on to advanced topics, making it perfect for newcomers to the field of channel coding.
180 worked examples guide students through the practical application of the theory.