We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
To evaluate the prognostic value of electrocardiographic ventricular repolarisation parameters in children with dilated cardiomyopathy.
Methods:
A retrospective study was conducted involving 89 children with dilated cardiomyopathy [age 5.24 (4.32, 6.15) years] as the research group, and a control group consisting of 80 healthy children matched for age and sex. Within the research group, there were 76 cases in the survival subgroup and 13 cases in the death subgroup. Ventricular repolarisation parameters were measured.
Results:
(1) Compared to the control group, both QTcmax and QTcmin were significantly prolonged in the research group (P < 0.01). Additionally, Tp-Te /QT ratios for leads III, aVL, V1, V2, and V3 showed an increase (P < 0.05), while T-wave amplitudes for leads I, II, aVL, aVF, V4, V5, and V6 exhibited a decrease (P < 0.05). (2) In comparison to the survival subgroup, the diameters of the LV, RV, LA, and RA in the death subgroup were enlarged, while the left ventricular ejection fraction and eft ventricular fractional shortening were decreased (P < 0.05). The Tp-Te /QT ratios for leads aVR, V5, and V6 also increased notably (P < 0.05 or P < 0.01). The T-wave amplitude readings from leads II, aVF, and V6 demonstrated significant reductions (P < 0.05).
Conclusion:
Abnormal ventricular repolarisation parameters were found in dilated cardiomyopathy children. Increased Tp-Te /QT ratios in aVR, V5, and V6 leads and decreased T-wave amplitudes in II, aVF, and V6 leads were risk factors for predicting mortality in children with dilated cardiomyopathy.
This meta-analysis assesses the relationship between vitamin D supplementation and incidence of major adverse cardiovascular events (MACEs). Pubmed, Web of science, Ovid, Cochrane Library and Clinical Trials were used to systematically search from their inception until July 2024. Hazard ratios (HR) and 95% confidence intervals (95%CI) were employed to assess the association between vitamin D supplementation and MACEs. This analysis included 5 randomized controlled trials (RCTs). Pooled results showed no significant difference in the incidence of MACEs (HR: 0.96; p=0.77), expanded MACEs (HR: 0.96; p=0.77) between the vitamin D intervention group and the control group. Further, the vitamin D intervention group had a lower incidence of myocardial infarction (MI), but the difference was not statistically significant (HR: 0.88, 95%CI: 0.77-1.01; p=0.061); nevertheless, vitamin D supplementation had no effect on the reduced incidence of stroke (p=0.675) or cardiovascular death (p=0.422). Among males (p=0.109) and females (p=0.468), vitamin D supplementation had no effect on the reduced incidence of MACEs. For participants with a body mass index (BMI)<25 kg/m2, the difference was not statistically significant (p=0.782); notably, the vitamin D intervention group had a lower incidence of MACEs for those with BMI≥25 kg/m2 (HR: 0.91, 95%CI: 0.83-1.00; p=0.055). Vitamin D supplementation did not significantly contribute to the risk reduction of MACEs, stroke and cardiovascular death in the general population, but may be helpful for MI. Notably, effect of vitamin D supplementation for MACEs was influenced by BMI. Overweight/obese people should be advised to take vitamin D to reduce the incidence of MACEs.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the synovial membrane, leading to cartilage destruction and bone erosion. Due to the complex pathogenesis of RA and the limitations of current therapies, increasing research attention has been directed towards novel strategies targeting fibroblast-like synoviocytes (FLS), which are key cellular components of the hyperplastic pannus. Recent studies have highlighted the pivotal role of FLS in the initiation and progression of RA, driven by their tumour-like transformation and the secretion of pro-inflammatory mediators, including cytokines, chemokines and matrix metalloproteinases. The aggressive phenotype of RA-FLS is marked by excessive proliferation, resistance to apoptosis, and enhanced migratory and invasive capacities. Consequently, FLS-targeted therapies represent a promising avenue for the development of next-generation RA treatments. The efficacy of such strategies – particularly those aimed at modulating FLS signalling pathways – has been demonstrated in both preclinical and clinical settings, underscoring their therapeutic potential. This review provides an updated overview of the pathogenic mechanisms and functional roles of FLS in RA, with a focus on critical signalling pathways under investigation, including Janus kinase/signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-κB), Notch and interleukin-1 receptor-associated kinase 4 (IRAK4). In addition, we discuss the emerging understanding of FLS-subset-specific contributions to immunometabolism and explore how computational biology is shaping novel targeted therapeutic strategies. A deeper understanding of the molecular and functional heterogeneity of FLS may pave the way for more effective and precise therapeutic interventions in RA.
In this study, the method of large-eddy simulation (LES) is applied to investigate the impact of patches of coarsened riverbed sediments on near-bed hydrodynamics and flow resistance. Six simulations are performed with riverbed coverage ratios of coarser particles (Ac/At, where Ac and At are the riverbed area covered by coarsened sediments and the total riverbed area, respectively) ranging from 0 % to 100 %. By ensuring identical crest heights for all particles, the influence of heterogeneous roughness height is eliminated, allowing for an isolated investigation of heterogeneous permeability effects. Results reveal distinct high- and low-flow streaks above coarsened and uncoarsened sediments, associated with elevated and reduced Reynolds shear stress, respectively. These streaky patterns are attributed to time-averaged secondary flows spanning the entire water depth, that converge toward coarsened sediments and diverge from uncoarsened areas. Elevated Reynolds shear stress, up to 1.9 times the reach-averaged bed shear stress, is observed in the interstitial spaces between coarser particles due to intensified hyporheic exchange at the sediment–water interface. Upwelling and downwelling flows occur upstream and downstream of coarsened sediments particles, respectively, driving dominant ejection and sweep events. At Ac/At = 16 %, ejections and sweeps contribute maximally to Reynold shear stress, increasing by up to 130 % and 110 %, respectively – approximately double their contributions in the uncoarsened case. The study identifies two mechanisms driving increased flow resistance over coarsened riverbeds: water-depth-scale secondary flows and grain-scale hyporheic exchanges. Consequently, the reach-averaged friction factor increases by 29.8 % from Ac/At = 0 % to 64 %, followed by a 15.8 % reduction in the fully coarsened scenario.
The 1994 discovery of Shor's quantum algorithm for integer factorization—an important practical problem in the area of cryptography—demonstrated quantum computing's potential for real-world impact. Since then, researchers have worked intensively to expand the list of practical problems that quantum algorithms can solve effectively. This book surveys the fruits of this effort, covering proposed quantum algorithms for concrete problems in many application areas, including quantum chemistry, optimization, finance, and machine learning. For each quantum algorithm considered, the book clearly states the problem being solved and the full computational complexity of the procedure, making sure to account for the contribution from all the underlying primitive ingredients. Separately, the book provides a detailed, independent summary of the most common algorithmic primitives. It has a modular, encyclopedic format to facilitate navigation of the material and to provide a quick reference for designers of quantum algorithms and quantum computing researchers.
This chapter covers quantum algorithmic primitives for loading classical data into a quantum algorithm. These primitives are important in many quantum algorithms, and they are especially essential for algorithms for big-data problems in the area of machine learning. We cover quantum random access memory (QRAM), an operation that allows a quantum algorithm to query a classical database in superposition. We carefully detail caveats and nuances that appear for realizing fast large-scale QRAM and what this means for algorithms that rely upon QRAM. We also cover primitives for preparing arbitrary quantum states given a list of the amplitudes stored in a classical database, and for performing a block-encoding of a matrix, given a list of its entries stored in a classical database.
This chapter covers the multiplicative weights update method, a quantum algorithmic primitive for certain continuous optimization problems. This method is a framework for classical algorithms, but it can be made quantum by incorporating the quantum algorithmic primitive of Gibbs sampling and amplitude amplification. The framework can be applied to solve linear programs and related convex problems, or generalized to handle matrix-valued weights and used to solve semidefinite programs.
This chapter covers quantum algorithmic primitives related to linear algebra. We discuss block-encodings, a versatile and abstract access model that features in many quantum algorithms. We explain how block-encodings can be manipulated, for example by taking products or linear combinations. We discuss the techniques of quantum signal processing, qubitization, and quantum singular value transformation, which unify many quantum algorithms into a common framework.
In the Preface, we motivate the book by discussing the history of quantum computing and the development of the field of quantum algorithms over the past several decades. We argue that the present moment calls for adopting an end-to-end lens in how we study quantum algorithms, and we discuss the contents of the book and how to use it.
This chapter covers the quantum adiabatic algorithm, a quantum algorithmic primitive for preparing the ground state of a Hamiltonian. The quantum adiabatic algorithm is a prominent ingredient in quantum algorithms for end-to-end problems in combinatorial optimization and simulation of physical systems. For example, it can be used to prepare the electronic ground state of a molecule, which is used as an input to quantum phase estimation to estimate the ground state energy.
This chapter covers quantum linear system solvers, which are quantum algorithmic primitives for solving a linear system of equations. The linear system problem is encountered in many real-world situations, and quantum linear system solvers are a prominent ingredient in quantum algorithms in the areas of machine learning and continuous optimization. Quantum linear systems solvers do not themselves solve end-to-end problems because their output is a quantum state, which is one of its major caveats.
This chapter presents an introduction to the theory of quantum fault tolerance and quantum error correction, which provide a collection of techniques to deal with imperfect operations and unavoidable noise afflicting the physical hardware, at the expense of moderately increased resource overheads.
This chapter covers the quantum algorithmic primitive called quantum gradient estimation, where the goal is to output an estimate for the gradient of a multivariate function. This primitive features in other primitives, for example, quantum tomography. It also features in several quantum algorithms for end-to-end problems in continuous optimization, finance, and machine learning, among other areas. The size of the speedup it provides depends on how the algorithm can access the function, and how difficult the gradient is to estimate classically.
This chapter covers quantum algorithms for numerically solving differential equations and the areas of application where such capabilities might be useful, such as computational fluid dynamics, semiconductor chip design, and many engineering workflows. We focus mainly on algorithms for linear differential equations (covering both partial and ordinary linear differential equations), but we also mention the additional nuances that arise for nonlinear differential equations. We discuss important caveats related to both the data input and output aspects of an end-to-end differential equation solver, and we place these quantum methods in the context of existing classical methods currently in use for these problems.
This chapter covers the quantum algorithmic primitive of approximate tensor network contraction. Tensor networks are a powerful classical method for representing complex classical data as a network of individual tensor objects. To evaluate the tensor network, it must be contracted, which can be computationally challenging. A quantum algorithm for approximate tensor network contraction can provide a quantum speedup for contracting tensor networks that satisfy certain conditions.
This chapter provides an overview of how to perform quantum error correction using the surface code, which is the most well-studied quantum error correcting code for practical quantum computation. We provide formulas for the code distance—which determines the resource overhead when using the surface code—as a function of the desired logical error rate and underlying physical error rate. We discuss several decoders for the surface code and the possibility of experiencing the backlog problem if the decoder is too slow.