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To determine whether depressive symptoms in traumatic brain injury (TBI) patients were associated with altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression.
Methods
In the present study, we examined 79 patients (57 males; age range = 17–70 years, M ± s.d. = 38 ± 16.13; BDI-II, M ± s.d. = 9.84 ± 8.67) with TBI. We used structural MRI and resting-state fMRI to examine whether there was a relationship between depression, as measured with the Beck Depression Inventory (BDI-II), and the voxel-based morphology or functional connectivity in regions previously identified as involved in emotional regulation in patients following TBI. Patients were at least 4 months post-TBI (M ± s.d. = 15.13 ± 11.67 months) and the severity of the injury included mild to severe cases [Glasgow Coma Scale (GCS), M ± s.d. = 6.87 ± 3.31].
Results
Our results showed that BDI-II scores were unrelated to voxel-based morphology in the examined regions. We found a positive association between depression scores and rs-fc between limbic regions and cognitive control regions. Conversely, there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation.
Conclusion
These findings lead to a better understanding of the exact mechanisms that contribute to depression following TBI and better inform treatment decisions.
Few personalised medicine investigations have been conducted for mental health. We aimed to generate and validate a risk tool that predicts adult attention-deficit/hyperactivity disorder (ADHD).
Methods
Using logistic regression models, we generated a risk tool in a representative population cohort (ALSPAC – UK, 5113 participants, followed from birth to age 17) using childhood clinical and sociodemographic data with internal validation. Predictors included sex, socioeconomic status, single-parent family, ADHD symptoms, comorbid disruptive disorders, childhood maltreatment, ADHD symptoms, depressive symptoms, mother's depression and intelligence quotient. The outcome was defined as a categorical diagnosis of ADHD in young adulthood without requiring age at onset criteria. We also tested Machine Learning approaches for developing the risk models: Random Forest, Stochastic Gradient Boosting and Artificial Neural Network. The risk tool was externally validated in the E-Risk cohort (UK, 2040 participants, birth to age 18), the 1993 Pelotas Birth Cohort (Brazil, 3911 participants, birth to age 18) and the MTA clinical sample (USA, 476 children with ADHD and 241 controls followed for 16 years from a minimum of 8 and a maximum of 26 years old).
Results
The overall prevalence of adult ADHD ranged from 8.1 to 12% in the population-based samples, and was 28.6% in the clinical sample. The internal performance of the model in the generating sample was good, with an area under the curve (AUC) for predicting adult ADHD of 0.82 (95% confidence interval (CI) 0.79–0.83). Calibration plots showed good agreement between predicted and observed event frequencies from 0 to 60% probability. In the UK birth cohort test sample, the AUC was 0.75 (95% CI 0.71–0.78). In the Brazilian birth cohort test sample, the AUC was significantly lower –0.57 (95% CI 0.54–0.60). In the clinical trial test sample, the AUC was 0.76 (95% CI 0.73–0.80). The risk model did not predict adult anxiety or major depressive disorder. Machine Learning approaches did not outperform logistic regression models. An open-source and free risk calculator was generated for clinical use and is available online at https://ufrgs.br/prodah/adhd-calculator/.
Conclusions
The risk tool based on childhood characteristics specifically predicts adult ADHD in European and North-American population-based and clinical samples with comparable discrimination to commonly used clinical tools in internal medicine and higher than most previous attempts for mental and neurological disorders. However, its use in middle-income settings requires caution.
The snow surface roughness at centimetre and millimetre scales is an important parameter related to wind transport, snowdrifts, snowfall, snowmelt and snow grain size. Knowledge of the snow surface roughness is also of high interest for analyzing the signal from radar sensors such as SAR, altimeters and scatterometers. Unfortunately, this parameter has seldom been measured over snow surfaces. The techniques used to measure the roughness of other surfaces, such as agricultural or sand soils, are difficult to implement in polar regions because of the harsh climatic conditions. In this paper we develop a device based on a laser profiler coupled with a GPS receiver on board a snowmobile. This instrumentation was tested successfully in midre Lovénbreen, Svalbard, in April 2006. It allowed us to generate profiles of 3 km sections of the snow-covered glacier surface. Because of the motion of the snowmobile, the roughness signal is mixed with the snowmobile signal. We use a distance/frequency analysis (the empirical mode decomposition) to filter the signal. This method allows us to recover the snow surface structures of wavelengths between 4 and 50 cm with amplitudes of >1 mm. Finally, the roughness parameters of snow surfaces are retrieved. The snow surface roughness is found to be dependent on the scales of the observations. The retrieved RMS of the height distribution is found to vary between 0.5 and 9.2 mm, and the correlation length is found to be between 0.6 and 46 cm. This range of measurements is particularly well adapted to the analysis of GHz radar response on snow surfaces.
Recovery Ice Stream has multiple branches reaching far into the East Antarctic ice sheet. We use new airborne and ground-based geophysics to give the first comprehensive overview of the upper catchment and, by constraining the physical setting, to advance our understanding of the controlling mechanisms for the onset of fast flow. The 400 km wide ice stream extends towards the Recovery Subglacial Lakes, a region characterized by a crustal boundary, a change in bed roughness, a bedrock topographic step and four topographic basins (A–D), three of which (A–C) contain subglacial water. All these characteristics are considered potential causal mechanisms that contribute to the onset of fast flow. In Lakes B and C the subglacial water is located in basins with sharp downstream ridges, in contrast to the gently sloping ridge on the downstream margin of Lake A. The fastest-flowing branch of the ice stream emanates from Lake A. The presence of multiple causal mechanisms along the four Recovery Lakes allows us to identify basal water as a dominant factor for the onset of fast flow, but only if it is stored in a shallow-sided basin where it can lubricate the flow downstream. Relatively minor topographic barriers appear to inhibit streaming.
Periods of rapid growth seen during the early stages of fetal development, including cell proliferation and differentiation, are greatly influenced by the maternal environment. We demonstrate here that over-nutrition, specifically exposure to a high-fat diet in utero, programed the extent of atherosclerosis in the offspring of ApoE*3 Leiden transgenic mice. Pregnant ApoE*3 Leiden mice were fed either a control chow diet (2.8% fat, n=12) or a high-fat, moderate-cholesterol diet (MHF, 19.4% fat, n=12). Dams were fed the chow diet during the suckling period. At 28 days postnatal age wild type and ApoE*3 Leiden offspring from chow or MHF-fed mothers were fed either a control chow diet (n=37) or a diet rich in cocoa butter (15%) and cholesterol (0.25%), for 14 weeks to induce atherosclerosis (n=36). Offspring from MHF-fed mothers had 1.9-fold larger atherosclerotic lesions (P<0.001). There was no direct effect of prenatal diet on plasma triglycerides or cholesterol; however, transgenic ApoE*3 Leiden offspring displayed raised cholesterol when on an atherogenic diet compared with wild-type controls (P=0.031). Lesion size was correlated with plasma lipid parameters after adjustment for genotype, maternal diet and postnatal diet (R2=0.563, P<0.001). ApoE*3 Leiden mothers fed a MHF diet developed hypercholesterolemia (plasma cholesterol two-fold higher than in chow-fed mothers, P=0.011). The data strongly suggest that maternal hypercholesterolemia programs later susceptibility to atherosclerosis. This is consistent with previous observations in humans and animal models.
The main results of the paper determine all real meromorphic functions f of finite lower order in the plane such that f has finitely many zeros and non-real poles and such that certain combinations of derivatives of f have few non-real zeros.
Let f be a real meromorphic function of infinite order in the plane, with finitely many zeros and non-real poles. Then f″ has infinitely many non-real zeros.
Attention-deficit hyperactivity disorder (ADHD) is recognised as a common, disabling condition. Little information is available regarding the long-term outcomes for individuals with ADHD in the UK.
Aims
To examine the 5-year outcome for a UK cohort of children with diagnosed, treated ADHD and identify whether maternal and social factors predict key outcomes.
Method
One hundred and twenty-six school-aged children (mean age 9.4 years, s.d. = 1.7) diagnosed with ADHD were reassessed 5 years later during adolescence (mean age 14.5 years, s.d. = 1.7) for ADHD, conduct disorder and other antisocial behaviours.
Results
Most adolescents (69.8%) continued to meet full criteria for ADHD, were known to specialist services and exhibited high levels of antisocial behaviour, criminal activity and substance use problems. Maternal childhood conduct disorder predicted offspring ADHD continuity; maternal childhood conduct disorder, lower child IQ and social class predicted offspring conduct disorder symptoms.
Conclusions
The treatment and monitoring of ADHD need to be intensified as outcomes are poor especially in offspring of mothers with childhood conduct disorder symptoms.
It is shown that if f is an analytic function of sufficiently small exponential type in the right half-plane, which takes integer values on a subset of the positive integers having positive lower density, then f is a polynomial.
We prove that for a function f(z) transcendental and meromorphic in the plane and not of the form exp(az + b), we have either N(r, 1/ff″)≠0(T(r, f′/f)) or .
For any sequence (aj) of complex numbers and for any ρ > ½, we construct an entire function F with the following properties. F has order ρ, mean type, each aj is a deficient value of F, and F is given by F(z)=f(g(z)), where f and g are transcendental entire functions. This complements a result of Goldstein. We also construct, for any ρ>½, an entire function G of order p, mean type, such that liminf,→ ∞ T(r, G)/T(r, G′)>1.
Let $f$ be meromorphic of finite order in the plane, such that $f^{(k)}$ has finitely many zeros, for some $k\geq2$. The author has conjectured that $f$ then has finitely many poles. In this paper, we strengthen a previous estimate for the frequency of distinct poles of $f$. Further, we show that the conjecture is true if either
$f$ has order less than $1+\varepsilon$, for some positive absolute constant $\varepsilon$, or
$f^{(m)}$, for some $0\leq m lt k$, has few zeros away from the real axis.
where A(z) is a transcendental entire function of finite order, and we are concerned specifically with the frequency of zeros of a non-trivial solution f(z) of (1.1). Of course it is well known that such a solution f(z) is an entire function of infinite order, and using standard notation from [7],
for all , b∈C\{0}, at least outside a set of r of finite measure.
We determine all functions f(z) meromorphic in the plane such that f′(z)/f(z) has finite order and f(z) and F(z) have only finitely many zeros, where F(z) = f″(z) + Af(z) for some constant A.
Let f be a function transcendental and meromorphic in the plane, and define g(z) by g(z) = Δf(z) = f(z + 1) − f(z). A number of results are proved concerning the existence of zeros of g(z) or g(z)/f(z), in terms of the growth and the poles of f. The results may be viewed as discrete analogues of existing theorems on the zeros of f' and f'/f.
Let f be transcendental and meromorphic in the plane and let the non-homogeneous linear differential polynomials F and G be defined bywhere k,n ∈ N and a, b and the aj, bj are rational functions. Under the assumption that F and G have few zeros, it is shown that either F and G reduce to homogeneous linear differential polynomials in f + c, where c is a rational function that may be computed explicitly, or f has a representation as a rational function in solutions of certain associated linear differential equations, which again may be determined explicitly from the aj, bj and a and b.
A result is proved which implies the following conjecture of Osgood and Yang from 1976: if $f$ and $g$ are non-constant entire functions, such that $ T(r, f) = O(T(r, g))$ as $ r \to \infty $ and such that $g(z) \in {\mathbb Z}$ implies that $f(z) \in {\mathbb Z}$, then there exists a polynomial $G$ with coefficients in ${\mathbb Q}$, such that $G({\mathbb Z}) \subseteq {\mathbb Z}$ and $f = G \circ g$.