We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
It remains unclear which individuals with subthreshold depression benefit most from psychological intervention, and what long-term effects this has on symptom deterioration, response and remission.
Aims
To synthesise psychological intervention benefits in adults with subthreshold depression up to 2 years, and explore participant-level effect-modifiers.
Method
Randomised trials comparing psychological intervention with inactive control were identified via systematic search. Authors were contacted to obtain individual participant data (IPD), analysed using Bayesian one-stage meta-analysis. Treatment–covariate interactions were added to examine moderators. Hierarchical-additive models were used to explore treatment benefits conditional on baseline Patient Health Questionnaire 9 (PHQ-9) values.
Results
IPD of 10 671 individuals (50 studies) could be included. We found significant effects on depressive symptom severity up to 12 months (standardised mean-difference [s.m.d.] = −0.48 to −0.27). Effects could not be ascertained up to 24 months (s.m.d. = −0.18). Similar findings emerged for 50% symptom reduction (relative risk = 1.27–2.79), reliable improvement (relative risk = 1.38–3.17), deterioration (relative risk = 0.67–0.54) and close-to-symptom-free status (relative risk = 1.41–2.80). Among participant-level moderators, only initial depression and anxiety severity were highly credible (P > 0.99). Predicted treatment benefits decreased with lower symptom severity but remained minimally important even for very mild symptoms (s.m.d. = −0.33 for PHQ-9 = 5).
Conclusions
Psychological intervention reduces the symptom burden in individuals with subthreshold depression up to 1 year, and protects against symptom deterioration. Benefits up to 2 years are less certain. We find strong support for intervention in subthreshold depression, particularly with PHQ-9 scores ≥ 10. For very mild symptoms, scalable treatments could be an attractive option.
This study examined children at the onset of tic disorder (tics for less than 9 months: NT group), a population on which little research exists. Here, we investigate relationships between the baseline shape and volume of subcortical nuclei, diagnosis, and tic symptom outcomes.
Methods
187 children were assessed at baseline and a 12-month follow-up: 88 with NT, 60 tic-free healthy controls (HC), and 39 with chronic tic disorder/Tourette syndrome (TS), using T1-weighted MRI and total tic scores (TTS) from the Yale Global Tic Severity Scale to evaluate symptom change. Subcortical surface maps were generated using FreeSurfer-initialized large deformation diffeomorphic metric mapping. Linear regression models correlated baseline structural shapes with follow-up TTS while accounting for covariates, with relationships mapped onto structure surfaces.
Results
We found that the NT group had a larger right hippocampus compared to HC. Surface maps illustrate distinct patterns of inward deformation in the putamen and outward deformation in the thalamus for NT compared to controls. We also found patterns of outward deformation in almost all studied structures when comparing the TS group to controls. The NT group also showed consistent outward deformation compared to TS in the caudate, accumbens, putamen, and thalamus. Subsequent analyses including clinical symptoms revealed that a larger pallidum and thalamus at baseline correlated with less improvement of tic symptoms at follow-up.
Conclusion
These observations constitute some of the first prognostic biomarkers for tic disorders and suggest that these subregional shape and volume differences may be associated with the outcome of tic disorders.
From early on, infants show a preference for infant-directed speech (IDS) over adult-directed speech (ADS), and exposure to IDS has been correlated with language outcome measures such as vocabulary. The present multi-laboratory study explores this issue by investigating whether there is a link between early preference for IDS and later vocabulary size. Infants’ preference for IDS was tested as part of the ManyBabies 1 project, and follow-up CDI data were collected from a subsample of this dataset at 18 and 24 months. A total of 341 (18 months) and 327 (24 months) infants were tested across 21 laboratories. In neither preregistered analyses with North American and UK English, nor exploratory analyses with a larger sample did we find evidence for a relation between IDS preference and later vocabulary. We discuss implications of this finding in light of recent work suggesting that IDS preference measured in the laboratory has low test-retest reliability.
The COVID-19 pandemic has presented youth and families with a broad spectrum of unique stressors. Given that adolescents are at increased risk for mental health and emotional difficulties, it is critical to explore family processes that confer resilience for youth in the face of stress. The current study investigated caregiver emotion regulation (ER) as a familial factor contributing to youth ER and risk for psychopathology following stressful life events. In a longitudinal sample of 224 youth (Mage = 12.65 years) and their caregivers, we examined whether caregiver and youth engagement in ER strategies early in the pandemic mediated the associations of pandemic-related stress with youth internalizing and externalizing symptoms six months later. Leveraging serial mediation analysis, we demonstrated that caregiver and youth rumination, but not expressive suppression or cognitive reappraisal, mediated the prospective associations of pandemic-related stress with youth internalizing and externalizing symptoms. Greater exposure to pandemic-related stressors was associated with greater caregiver rumination, which, in turn, related to greater rumination in youth, and higher levels of youth internalizing and externalizing symptoms thereafter. Family interventions that target caregiver ER, specifically rumination, may buffer against the consequences of stress on youth engagement in maladaptive ER strategies and risk for psychopathology.
We assessed the effectiveness of heterologous vaccination strategy in immunocompromised individuals regarding COVID-19 outcomes, comparing it to homologous approaches.
Design:
Systematic literature review/meta-analysis.
Methods:
We searched PubMed, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from January 1, 2020 to September 29, 2023. We included studies that evaluated the heterologous vaccination strategy on immunocompromised individuals through outcomes related to COVID-19 (levels of anti-SARS-CoV-2 spike protein IgG, neutralizing antibodies, symptomatic COVID-19 infection, hospitalization, and death) in comparison to homologous schemes. We also used random-effect models to produce pooled odds ratio estimates. Heterogeneity was investigated with I2 estimation.
Results:
Eighteen studies met the inclusion criteria for this systematic review. Fourteen of them provided quantitative data for inclusion in the meta-analysis on vaccine response, being four of them also included in the vaccine effectiveness meta-analysis. The vaccination strategies (heterologous vs homologous) showed no difference in the odds of developing anti-SARS-CoV-2 spike protein IgG (odds ratio 1.12 [95% Cl: 0.73–1.72]). Heterologous schemes also showed no difference in the production of neutralizing antibodies (odds ratio 1.48 [95% Cl: 0.72–3.05]) nor vaccine effectiveness in comparison to homologous schemes (odds ratio 1.52 [95% CI: 0.66–3.53]).
Conclusions:
Alternative heterologous COVID-19 vaccinations have shown equivalent antibody response rates and vaccine effectiveness to homologous schemes, potentially aiding global disparity of vaccine distribution.
Most of the Ross Sea has been designated a marine protected area (MPA), proposed ‘to protect ecosystem structure and function’. To assess effectiveness, the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR) selected Adélie (Pygoscelis adeliae) and emperor (Aptenodytes forsteri) penguins, Weddell seals (Leptonychotes weddellii) and Antarctic toothfish (Dissostichus mawsoni) as ecosystem change ‘indicator species’. Stable for decades, penguin and seal populations increased during 1998–2018 to surpass historical levels, indicating that change in ecosystem structure and function is underway. We review historical impacts to population trends, decadal datasets of ocean climate and fishing pressure on toothfish. Statistical modelling for Adélie penguins and Weddell seals indicates that variability in climate factors and cumulative extraction of adult toothfish may explain these trends. These mesopredators, and adult toothfish, all prey heavily on Antarctic silverfish (Pleuragramma antarcticum). Toothfish removal may be altering intraguild predation dynamics, leading to competitive release of silverfish and contributing to penguin and seal population changes. Despite decades of ocean/weather change, increases in indicator species numbers around Ross Island only began once the toothfish fishery commenced. The rational-use, ecosystem-based viewpoint promoted by CCAMLR regarding toothfish management needs re-evaluation, including in the context of the Ross Sea Region MPA.
In this chapter, we describe the context of the 2020 presidential election campaign, including the COVID-19 pandemic, racial justice protests, a highly contentious debate, and challenges to the integrity of the election. We review the state of the literature, showing that messages from the candidates, political parties, and the news media inform voters about the candidates’ policy positions, policy priorities, and personal characteristics. And campaign messages, via the candidates or the news media, can alter the criteria voters consider when evaluating the competing candidates. Finally, aspects of the campaign can encourage or discourage participation in the election. We turn next to presenting the citizen-centered theory of campaigns. We argue that people’s predispositions (i.e., political and psychological) drive the procurement and assimilation of information, which influence how individuals evaluate campaign events and campaign issues, and ultimately these evaluations influence their views of the competing candidates and their voting decisions. Finally, we discuss our three-way panel study where we gather information from the same individuals at different points during the 2020 campaign, allowing us to model how campaign events change people’s attitudes about the presidential candidates.
In this chapter, we highlight the impressive evidence for the citizen-centered theory of campaigns. We find that psychological predispositions do not simply reinforce partisan orientation. Instead, these predispositions tap distinct characteristics, influencing how people view the events and issues of the campaign. We also make suggestions about how to study campaigns in the future. While the electoral context of 2020 highlighted particular psychological predispositions, future elections are likely to put a premium on alternative psychological predispositions (e.g., benevolent racism, need for affect). We encourage researchers to be more exhaustive, systematic, and consistent in exploring the impact of people’s psychological predispositions during campaigns. We also review and speculate about how candidates’ campaign strategies may have helped shape the outcome, especially when we consider the razor thin vote margins in a few key states. Specifically, it appears Trump’s actions worked to his detriment both in who voted and in who people supported. Finally, given the events and rhetoric associated with the 2020 campaign, we conclude by assessing the health of our representative system of government where elections play a vital role.
The 2020 presidential campaign occurred in the midst of the first worldwide pandemic in 100 years. The pandemic engulfed the United States for the entire length of the campaign and the incumbent president was hospitalized with the virus at the height of the fall campaign. In this chapter, we show that people’s concern about the coronavirus pandemic increased significantly after Trump contracted COVID-19. Furthermore, and consistent with the citizen-centered theory of campaigns, we find that psychological predispositions, along with political and demographic characteristics, substantively and significantly predict changes in worry about the coronavirus from September to October. For instance, people high in authoritarianism and conflict avoidance become significantly more worried about the coronavirus pandemic from September to October. Finally, we show that people are more likely to consider assessments of the candidates’ competence for dealing with the coronavirus when developing overall evaluations of the candidates in October – after Trump’s COVID-19 diagnosis – compared to September.
The citizen-centered theory of campaigns improves our understanding of participation in the 2020 election. In this chapter, we show that people who dislike conflict participate at a much higher rate than people who are more tolerant of conflict. We also show that people who watched the September presidential debate, people who have higher levels of confidence in the election results, and people with more polarized views of the social justice movement are significantly more likely to vote in the general election. The citizen-centered theory of campaigns also informs our understanding of convenience voting. People who are more sympathetic to Trump are more likely to heed his message of forgoing mail voting and going to the polls on Election Day. Further, people who dislike conflict are significantly more likely to rely on mail voting compared to voting on Election Day. Finally, views about the important issues of the campaign affect how people choose to cast a ballot; people who are more concerned about the COVID-19 pandemic and people with more confidence in the integrity of the election are more likely to vote by mail than in person on Election Day.
In this chapter, we develop a comprehensive model where we include assessments of each campaign event (e.g., September debate) and issue (e.g., election integrity, worries about COVID-19) when predicting overall evaluations of Biden and Trump in November as well as changes in feeling thermometer scores from September to November. These models show that views about the first presidential debate and attitudes toward major campaign issues (i.e., election integrity, COVID-19, social justice protests) explain views of the candidates in November and predict shifts in evaluations over the length of the campaign. Finally, we estimate changes in vote preference from September to November and we find that elements of the campaign (e.g., views about the presidential debate, support for social justice protests) produce important changes in vote preferences. In other words, we find strong evidence that the 2020 campaign mattered.
Presidential debates are now a fixture in the landscape of fall campaigns for the presidency. They attract worldwide media attention, as well as the interest of tens of millions of potential voters, and are held in close proximity to Election Day. In 2020, the first general election debate was a donnybrook. In this chapter, we show that citizens develop clear opinions about who won the debate and who performed well; more people viewed Biden as the winner of the first debate and his performance ratings were significantly higher than Trump’s ratings, except among Republicans. We also demonstrate that people who have low tolerance for conflict develop significantly more negative views of Trump’s performance and are significantly more likely to consider Biden the winner of the debate. Furthermore, people’s level of racism and conspiratorial thinking shape views of Trump’s and Biden’s performances during the first presidential debate. Finally, evaluations of the candidates’ performance in the debate as well as people’s views of who won the debate influence overall evaluations of Trump and Biden and produce significant changes in the ratings of Trump and Biden from September to October.