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Contains 'A note on the foundation of Northill College in 1406', by Peter Hull. (An introduction is followed by a transcription in Latin of the College's foundation grant.) 'The origin of St. Mary's Square, Bedford', by J. Fines. (Transcription in English of a return to the exchequer by John Maygott, incumbent of the united parishes of St. Peter Dunstable and St. Mary, concerning the site and use to which the materials were put after the demolition of the former church c. 1555.)
'The Black Book of Bedford', by G. D. Gilmore. (The Black Book contains the constitutions or byelaws of the borough of Bedford made between 1562 and 1603.)
'Estate and household management in Bedfordshire, c. 1540', by A. G. Dickens. (A transcription of instructions and advice written by Sir John Gostwick of Willington addressed to his son William.)
'The Gostwicks of Willington', by H. P. R. Finberg. (The Gostwicks were typical of many families in the upper-middle stratum of society. They began as yeomen, rose to the gentry under Henry VIII, then suffered varying fortunes. The article includes a chronology of the family’s activities 1524-1804 and a nine-generation pedigree over three centuries from 1490s).
We describe severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG seroprevalence and antigenemia among patients at a medical center in January–March 2021 using residual clinical blood samples. The overall seroprevalences were 17% by infection and 16% by vaccination. Spent or residual samples are a feasible alternative for rapidly estimating seroprevalence or monitoring trends in infection and vaccination.
Archaeological sites in the Canadian Arctic often contain substantial quantities of marine mammal bones and in some cases completely lack terrestrial mammal bones. A distrust of radiocarbon (14C) dates on marine mammal bones among Arctic archaeologists has caused many sites to be insufficiently dated. The goal of this study was to investigate the marine reservoir effect on Atlantic walrus in the Foxe Basin region of the Canadian Arctic through a two-pronged approach: dating of live-harvested specimens of known age collected prior to AD 1955 and dating of pairs of animal remains (walrus and caribou) from stratigraphically contemporaneous levels within archaeological features. 14C dates on pre-bomb, live-harvested walrus indicate that a ΔR value of 160±50 yr be used in calibrating dates on walrus from this region. These results differed significantly from a similar set of pre-bomb mollusks, which argues against applying mollusk-based corrections to marine mammals. The results of comparative dating of caribou and walrus from archaeological features provided maximum estimates of reservoir ages that were more varied than the directly measured ages. Although about half of inferred ΔR values overlap the museum specimen results, the others indicate that the assumption of contemporaneity does not hold true.
Sand hills in the Savannah River valley in Jasper County (South Carolina, USA) are interpreted as the remnants of parabolic eolian dunes composed of sand derived from the Savannah River and stabilized by vegetation under prevailing climate conditions. Optically stimulated luminescence ages reveal that most of the dunes were active ca. 40 to 19 ka ago, coincident with the last glacial maximum (LGM) through early deglaciation. Modern surface winds are not sufficient for sustained eolian sand transport. When the dunes were active, winds blew at velocities of at least 4 m/s from west to east, and some vegetation was present. The ratio of annual precipitation to potential evapotranspiration (P:PE) was less than the modern ratio of 1.23 and may have been < 0.30, caused by stronger winds (which would have resulted in greater evaporation) and/or reduced precipitation. The Savannah River dunes are part of a larger assemblage of eolian dunes that were active in the eastern United States during and immediately after the LGM, suggesting that eolian sediment behavior in this region has been controlled by regional forcing mechanisms during the Quaternary.
A case of motor neuron disease with clinical and pathological resemblance to amyotrophic lateral sclerosis (ALS) in a woman who was severely bitten on the ankle by a cat is described. Weakness first appeared at the ankles and relentlessly advanced proximally, terminating in death from pulmonary failure in a year. A number of unusual features that are uncharacteristic of ALS were found that included a markedly elevated antinuclear antibody titre in the serum and the presence of prominent oligoclonal bands in the cerebrospinal fluid. The spinal cord showed loss of anterior horn cells and pyramidal degeneration that are characteristic of ALS, but an extraordinary finding was the presence of transmural granulomatous inflammation of numerous small and medium sized vessels, especially veins, in the subarachnoid space around the cord. There were also inflammatory changes in the brainstem and spinal cord consisting of microglial and astrocytic nodules and perivenous cuffing by mononuclear cells. Ill-defined hyaline eosinophilic cytoplasmic inclusions were seen in some remaining anterior horn cells. No viral particles were found by electron microscopy despite an extensive search. Virological studies were inconclusive but there is reason to believe that this patient's illness was caused by an as yet unidentified virus.
Background: Neither professional consensus nor evidence exists to guide the choice of essential hospital disaster interventions. The objective of our study was to demonstrate a method for developing consensus on hospital disaster interventions that should be regarded as essential, quantitatively balancing needs and resources.
Methods: A panel of pediatric acute care practitioners developed consensus using a modified Delphi process. Interventions were chosen such that workload per staff member would not exceed the previously validated maximum according to the Therapeutic Intervention Scoring System. Based on published models, it was assumed that the usual numbers of staff would care for a disaster surge of 4 times the usual number of intensive care and non–intensive care hospital patients.
Results: Using a single set of assumptions on constrained resources and overwhelming needs, the panel ranked and agreed on essential interventions. A number of standard interventions would exceed crisis workload constraints, including detailed recording of vital signs and fluid balance, administration of vasoactive agents, invasive monitoring of pressures (central venous, intraarterial, intracranial), dialysis, and tube feedings.
Conclusions: The quantitative methodology and consensus development process described in the present report may have utility in future planning. Groups with appropriate expertise must develop action plans according to authority within each jurisdiction, addressing likely disaster scenarios, according to the needs in each medical service region, using available regional resources, and accounting for the capabilities of each institution. (Disaster Med Public Health Preparedness. 2009;3:27–32)
Whereas efforts toward graphene commercialization are still in their early stages, lessons from the commercialization of carbon nanotubes (CNTs) might be applicable, given the similarities between the two materials (specifically, a single-walled CNT can be thought of as a monolayer of graphene wrapped into a cylinder). This article reviews the commercialization of CNT materials (with a special emphasis on single-walled CNTs) in selected electronics applications, including specific examples of successes, failures, and promising opportunities. Two application areas are reviewed: (1) alternatives to silicon for fabricating transistors used in display backplanes, radio-frequency identification, and smart cards, for example, and (2) alternatives to indium tin oxide for transparent conductive films used in displays, electronic paper for e-readers, touch sensors, light-emitting diode lighting, photovoltaics, and electrochromic windows. Some important lessons learned from these commercialization experiences can potentially help accelerate the commercialization of other exciting nanomaterials such as graphene.
Normative and reliability data for the Excluded Letter Fluency (ELF) Test are provided. A stratified random sample of 399 healthy young adults aged 18 to 34 years from Sydney, Australia, completed the ELF Test as well as a full-length WAIS-R, as part of a larger battery of tests. After a 1-year interval 99 of these individuals were retested on the same forms of the tests. The influence of age, sex and education was investigated on the ELF and only education was found to have a significant overall effect on the total scores. However, gender was found to have an effect on the error scores, with males making more rule-breaks than females. Tables are provided for converting ELF raw scores, corrected for years of education, to standard scores with 90% and 95% confidence intervals for both test and retest purposes. A table for calculating the base rate of errors, for males and for females, on the ELF is also provided.