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Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
The First Large Absorption Survey in H i (FLASH) is a large-area radio survey for neutral hydrogen in and around galaxies in the intermediate redshift range $0.4\lt z\lt1.0$, using the 21-cm H i absorption line as a probe of cold neutral gas. The survey uses the ASKAP radio telescope and will cover 24,000 deg$^2$ of sky over the next five years. FLASH breaks new ground in two ways – it is the first large H i absorption survey to be carried out without any optical preselection of targets, and we use an automated Bayesian line-finding tool to search through large datasets and assign a statistical significance to potential line detections. Two Pilot Surveys, covering around 3000 deg$^2$ of sky, were carried out in 2019-22 to test and verify the strategy for the full FLASH survey. The processed data products from these Pilot Surveys (spectral-line cubes, continuum images, and catalogues) are public and available online. In this paper, we describe the FLASH spectral-line and continuum data products and discuss the quality of the H i spectra and the completeness of our automated line search. Finally, we present a set of 30 new H i absorption lines that were robustly detected in the Pilot Surveys, almost doubling the number of known H i absorption systems at $0.4\lt z\lt1$. The detected lines span a wide range in H i optical depth, including three lines with a peak optical depth $\tau\gt1$, and appear to be a mixture of intervening and associated systems. Interestingly, around two-thirds of the lines found in this untargeted sample are detected against sources with a peaked-spectrum radio continuum, which are only a minor (5–20%) fraction of the overall radio-source population. The detection rate for H i absorption lines in the Pilot Surveys (0.3 to 0.5 lines per 40 deg$^2$ ASKAP field) is a factor of two below the expected value. One possible reason for this is the presence of a range of spectral-line artefacts in the Pilot Survey data that have now been mitigated and are not expected to recur in the full FLASH survey. A future paper in this series will discuss the host galaxies of the H i absorption systems identified here.
Population monitoring provides information on species conservation status. We reassess the status of the southern elephant seal population at Macquarie Island. The number of cows on the isthmus, ~20% of the total population, correlated with counts for the whole island (i.e. they reliably indicate island-wide trends). Cow numbers within the isthmus decreased from ~9400 in 1949 to ~2550 in 2023 at −1.1% year−1, similar to the −0.8% year−1 from 1984 to 2023 when counts were made annually (before 1984, counts were less systematic). This contrasts with all other southern elephant seal populations, which are either stable or increasing. There was also considerable year to year variability (± 350 cows year−1) in the numbers of cows ashore, indicating individuals skipping breeding. Counting errors may contribute to this variability but are unlikely given that the isthmus study area harems are small, typically < 200 cows. We found no link between cow numbers and summer ocean conditions using the Southern Annular Mode as a proxy (i.e. prior to blastocyst implantation), and it remains unclear what is causing this variation. Nonetheless, several other studies have suggested changing prey conditions during the winter are the most likely cause of this overall and ongoing decrease.
What legal rules govern how artists live and create artworks and sell those works to collectors and others? This chapter first addresses how artists live and work. It then turns to legal and ethical issues of the primary market for artists’ works, including: how artists sell their works, particularly through dealers; the legal rules that govern consignments, the predominant way artists sell works through dealers; the artist/dealer relationship (for example, what happens when the artist or dealer terminates the relationship, and who bears the loss when works not yet sold by the dealer are damaged or destroyed); statutory protection for artists’ consignments; and the commissioning of an artist to create a work of art.
For centuries, art has been one of the spoils of war, often taken by the victor--and often destroyed in combat. What rules govern how art is treated in and after times of armed conflict? This chapter considers practical and ethical challenges of protecting art and antiquities in times of war and how attitudes toward protection of cultural property have evolved, leading to the Hague Convention of 1954; how art has been treated as part of war reparations; legal and ethical issues applicable to the recovery of art in the aftermath of World War II, particularly in light of the Holocaust and the Third Reich’s historically unprecedented, large-scale dispossession of art; and international efforts to coordinate the return of art wrongfully taken in the years prior to and during World War II
This chapter considers legal and ethical issues affecting art museums. These issues include considering the legal and working definitions of a museum and how museums are legally organized in the United States; the tax status of museums; legal and ethical standards of museum governance,; the rules, practices, and ethical considerations pertaining to museums’ management of their collections; museums acquisitions and deaccessions of collections items; managing donor-imposed restrictions on gifts to museums; legal issues related to museum loans and exhibitions; and how museums address issues concerning access to their collections.
This chapter focuses on the legal and ethical rules applicable to the international trade in antiquities and other forms of cultural property. Over centuries, many countries have been primarily the source of antiquities; others have been primarily collectors of those antiquities . What rules govern the movement of antiquities and determine whether they should be returned to their country of origin? How does the United States deal with antiquities that are imported illegally or imported after being stolen or illicitly exported from other countries? This chapter also considers how museums can ethically collect antiquities and when antiquities can or should be returned to their country or place of origin.
This chapter examines issues concerning the secondary market for visual art--when artworks are resold after their initial sale by the artists. After considering the tension between art as creative expression and art as a commodity, bought and sold for profit, the chapter looks at how art dealers work with collectors; issues that can arise when works of art are entrusted to dealers; conflicts of interest that may arise for dealers; potential issues with appraisals of artworks in connection with resale; the legal rules governing art auctions; and some of the legal and ethical issues that can arise when art auctions go awry, such as the discovery after the auction that a work of art is not authentic.
Chapter 1 introduces the reader to the wide range of issues at the intersection of law, ethics, and the world of visual arts. The chapter then considers two threshold legal and philosophical issues that repeatedly arise throughout the book: how can and should the law define what is art and who is an artist?
Works of art, in addition to being treated at law as tangible personal property, also contain creative expression generally treated as intellectual property. This chapter considers the rules governing art as intellectual property. The chapter first presents copyright law as applied to visual art and how copyright infringement is established and defenses to infringement actions, including the fair use defense, especially as it applies to appropriation art and art that parodies other works. It then addresses how trademark law and the right of publicity (the right of individuals to control the use of their name, image, or likeness for commercial purposes) impact visual art. The chapter next examines resale royalties for art--where artists receive some portion of the price when their works resell in the secondary market--and the limited application of resale royalties in the U.S. Finally, the chapter explains artists’ moral rights,which allow artists to prevent the alteration or destruction of their works after they are sold and to control the use of their name in association with an artwork they did not create or that they created but that has been altered.