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Elephant grass [Cenchrus purpureus (Schum.) Morrone] is a tropical forage grass widely used in ruminant feeding in tropical and subtropical areas, mainly in cut-and-carry systems due to is high potential for herbage accumulation. However, most common genotypes (tall genotypes) generally show an early stem elongation, which contributes to a rapid decline in the forage nutritive value. Dwarf elephant grass types usually present less stem elongation and may be considered an option for the production of high nutritive value forage in cut-and-carry systems. The aims of this study were to evaluate and explain variations in herbage characteristics and kinetics of in vitro gas production of irrigated elephant grass genotypes (two tall-types – Elephant B and IRI-381 – and two dwarf-types genotypes – Mott and Taiwan A-146 2.37) under two harvest frequencies (60 and 90 days) in the dry and rainy seasons of two years. Herbage characteristics varied among genotypes, harvest frequency and seasons. Dwarf genotypes showed better in vitro fermentation parameters with the advancement of maturity compared to the tall size genotypes. Harvesting tall genotypes at a higher frequency (60-day) contributed to improving the fermentation, while dwarf elephant grass maintained greater fermentation when less frequent harvests were adopted (90-day).
We performed a systematic literature review to identify and describe pharmacist-led antimicrobial stewardship programs (ASPs) interventions in low- and middle-income countries (LMICs).
Design:
Systematic literature review.
Methods:
We searched PubMed for studies evaluating pharmacist-led ASP interventions in LMICs from January 1, 2012, to November 4, 2023. We evaluated the article’s country of origin, described ASP interventions, and analyzed their reported outcomes.
Results:
Twenty-four studies were included; ten were conducted in China, two in India, two in Thailand, five in Africa, three in Latin America, and two in the Middle East. The predominant interventions in the studies were education and training followed by audit and feedback. The outcomes reported included reduction in antimicrobial consumption, cost reduction, shortening of the duration of antimicrobial therapy, and de-escalation.
Conclusions:
Our findings reinforce the importance of clinical pharmacists leading interventions related to antimicrobial stewardship in LMCIs and the global importance of investing in Infectious Disease training.
An increase in peripheral blood eosinophils in helminth infections is expected, and these cells are known to promote immunity against these parasites. However, studies have suggested that in some specific helminths, eosinophils may promote the needs and longevity of these parasites, and their role in these infections remains undefined, including in Toxocara canis infection. Thus, this study aimed to investigate the role of eosinophils in the context of larval migration of T. canis and the immunopathological aspects of infection. For this, we used wild-type mice and mice genetically deficient for the transcription factor GATA-binding factor 1 (GATA1−/−), infected with 1000 eggs of T. canis. At 0, 3, 14 and 63 days post-infection, parasite load, tissue cytokine production, leucocyte profile, bronchoalveolar lavage cells and histopathological analyses were carried out. Collectively, our results demonstrate that the presence of eosinophils mediates susceptibility to T. canis, inducing leucocytosis and the formation of granulomas, increasing the pulmonary and cerebral parasite load, and reducing the number of neutrophils, which may be necessary to control the infection.
Unlike well-known global patterns of plant species richness along altitudinal gradients, in the mountainous areas of the Brazilian Caatinga, species richness and diversity reach their maxima near mountain tops. The causes of this unusual pattern are not well understood, and in particular the role of edaphic factors on plant community assembly along these gradients has not been investigated. Our goal was to assess the role of edaphic factors (fertility and soil texture) on plant community composition and structure on two mountains of the Brazilian semi-arid region. In 71 plots (Bodocongó site, twenty-one 200-m2 plots, 401–680 m asl; Arara site, fifty 100-m2 plots, 487–660 m asl) we recorded 3114 individuals representing 61 plant species; in addition, at each plot we collected composite soil samples from 0–20 cm depth. Significant altitude-related changes were observed both for community structure and composition, and edaphic variables. A canonical correspondence analysis allowed the distinction of two groups of plots according to species abundances, indicating a preferential habitat distribution of species depending both on altitude and soil variables. Although soil fertility was lowest at the highest altitudes, these areas had high richness and diversity. Conversely, the more fertile foothills were characterized by the dominance of generalist pioneer species. Despite the relatively short altitudinal range that characterizes the studied mountains, this study elucidates the role of edaphic factors on the floristic composition and species richness patterns on the mountains of the Brazilian semi-arid region.
Pelagic seabird populations have declined strongly worldwide. In the North Atlantic there was a huge reduction in seabird populations following the European colonization of the Azores, Madeira and Canary archipelagos but information on seabird status and distribution for the subtropical region of Cabo Verde is scarce, unavailable or dispersed in grey literature. We compiled and compared the historical and current distribution of all seabird species breeding in the Cabo Verde archipelago, updated their relative abundance, investigated their inland habitat preferences, and reviewed their threats. Currently, the breeding seabird community in Cabo Verde is composed of Bulwer’s Petrel Bulweria bulwerii, White-faced Storm-petrel Pelagodroma marina aedesorum, Cape Verde Shearwater Calonectris edwardsii, Cape Verde Storm-petrel Hydrobates jabejabe, Cape Verde Petrel Pterodroma feae, Boyd's Shearwater Puffinus lherminieri boydi, Brown Booby Sula leucogaster, and Red-billed Tropicbird Phaethon aethereus. One breeding species is currently extinct, the Magnificent Frigatebird Fregata magnificens. The relative abundance of Cape Verde Shearwater, Boyd’s Shearwater, Cape Verde Petrel, and Cape Verde Storm-petrel was determined from counts of their nocturnal calls in Santo Antão, São Vicente, Santa Luzia, Branco, Raso and São Nicolau. Cape Verde Petrel occurred only on mountainous islands (Santo Antão, São Nicolau, Santiago, and Fogo) from mid-to high elevations. Larger species such as the Cape Verde Shearwater and Boyd’s Shearwater exhibited a wider distribution in the archipelago, occurring close to the coastline but at lower densities on populated islands. Small procellariforms such as the Cape Verde Storm-petrel occurred at high densities only on rat-free islets and in steep areas of main islands where introduced cats and rats are unlikely to occur. The main threats to seabird populations in Cabo Verde range from predation by introduced predators, habitat alteration or destruction, and some residual human persecution.
Essential oils (EOs) are considered a new class of ecological products aimed at the control of insects for industrial and domestic use; however, there still is a lack of studies involving the control of fleas. Ctenocephalides felis felis, the most observed parasite in dogs and cats, is associated with several diseases. The aim of this study was to evaluate the in vitro activity, the establishment of LC50 and toxicity of EOs from Alpinia zerumbet (Pers.) B. L. Burtt & R. M. Sm, Cinnamomum spp., Laurus nobilis L., Mentha spicata L., Ocimum gratissimum L. and Cymbopogon nardus (L.) Rendle against immature stages and adults of C. felis felis. Bioassay results suggest that the method of evaluation was able to perform a pre-screening of the activity of several EOs, including the discriminatory evaluation of flea stages by their LC50. Ocimum gratissimum EO was the most effective in the in vitro assays against all flea stages, presenting adulticide (LC50 = 5.85 μg cm−2), ovicidal (LC50 = 1.79 μg cm−2) and larvicidal (LC50 = 1.21 μg cm−2) mortality at low doses. It also presented an excellent profile in a toxicological eukaryotic model. These findings may support studies involving the development of non-toxic products for the control of fleas in dogs and cats.
Individuals with bipolar disorder (BD) show aberrant brain activation patterns during reward and loss anticipation. We examined for the first time longitudinal changes in brain activation during win and loss anticipation to identify trait markers of aberrant anticipatory processing in BD.
Methods
Thirty-four euthymic and depressed individuals with BD-I and 17 healthy controls (HC) were scanned using functional magnetic resonance imaging twice 6 months apart during a reward task.
Results
HC, but not individuals with BD, showed longitudinal reductions in the right lateral occipital cortex (RLOC) activation during processing of cues predicting possible money loss (p-corrected <0.05). This result was not affected by psychotropic medication, mood state or the changes in depression/mania severity between the two scans in BD. Elevated symptoms of subthreshold hypo/mania at baseline predicted more aberrant longitudinal patterns of RLOC activation explaining 12.5% of variance in individuals with BD.
Conclusions
Increased activation in occipital cortex during negative outcome anticipation may be related to elevated negative emotional arousal during anticipatory cue processing. One interpretation is that, unlike HC, individuals with BD were not able to learn at baseline that monetary losses were smaller than monetary gains and were not able to reduce emotional arousal for negative cues 6 months later. Future research in BD should examine how modulating occipital cortical activation affects learning from experience in individuals with BD.
Magnetic fields pervade the universe and play an important role in many astrophysical processes. However, they require specialised observational tools, and are challenging to model and understand. This volume provides a unified view of magnetic fields across astrophysical and cosmological contexts, drawing together disparate topics that are rarely covered together. Written by the lecturers of the XXV Canary Islands Winter School, it offers a self-contained introduction to cosmic magnetic fields on a range of scales. The connections between the behaviours of magnetic fields in these varying contexts are particularly emphasised, from the relatively small and close ranges of the Sun, planets and stars, to galaxies and clusters of galaxies, as well as on cosmological scales. Aimed at young researchers and graduate students, this up-to-date review uniquely brings together a subject often tackled by disconnected communities, conveying the latest advances as well as highlighting the limits of our current understanding.
Magnetic fields play an important role in many astrophysical processes. They are difficult to detect and characterize because often their properties have to be inferred through interpreting the polarization of the light. Magnetic fields are also challenging to model and understand. Magnetized plasmas behave following highly non-linear differential equations having no general solution, so that every astrophysical problem represents a special case to be studied independently. Hence, magnetic fields are often an inconvenient subject that is overlooked or simply neglected (the elephant in the room, as they are dubbed on posters in the XXV Canary Islands Winter School of Astrophysics). Such a difficulty burdens the research on magnetic fields, which has evolved to become a very technical subject, with many small disconnected communities studying specific aspects and details. The school tried to amend the situation by providing a unifying view of the subject. The students had a chance to understand the behavior of magnetic fields in all astrophysical contexts, from cosmology to the Sun, and from starbursts to AGNs. The school was planned to present a balanced yet complete review of our knowledge, with excursions into the unknown to point out present and future lines of research.
The subject of Cosmic Magnetic Fields was split into seven different topics: cosmic magnetic field essentials, solar magnetic fields, stellar magnetic fields, the role of magnetic fields on AGN feedback, magnetic fields in galaxies, magnetic fields in galaxy clusters and at larger scales, and primordial magnetic fields and magnetic fields in the early Universe. The corresponding lectures were delivered by seven well known and experienced scientists that have played key roles in the major advances of the field during the last years: F. Cattaneo, P. Judge, O. Kochukhov, R. Keppens, R. Beck, K. Dolag, and F. Finelli. Their lectures were recorded and are freely available at the IAC website: http://iactalks.iac.es/talks/serie/19. Together with the reviews included in the present volume, they form a unique resource for both students and professional researchers. They provide a global view of this very compartmentalized, yet fundamental, field of research.
In this paper we introduce Hardy-Lorentz spaces with variable exponents associated withdilations in ${{\mathbb{R}}^{n}}$. We establish maximal characterizations and atomic decompositions for our variableexponent anisotropic Hardy-Lorentz spaces.
A paper of Almeida and Trotter [‘The pseudoidentity problem and reducibility for completely regular semigroups’, Bull. Aust. Math. Soc.63 (2001), 407–433] makes essential use of free profinite semigroupoids over profinite graphs with infinitely many vertices. It has since been shown that such structures must be handled with great care. In this note, it is verified that the required properties hold for the profinite graphs considered by Almeida and Trotter, thereby filling the gaps in the proof.