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Prolonged effusions post-Fontan procedure are associated with morbidity. Fontan patients have higher pro-inflammatory cytokines in chest tube drainage compared to controls. Colchicine, an anti-inflammatory medication, decreases effusions in adults after cardiac surgery. We hypothesised that patients post-Fontan treated with colchicine would have decreased pro-inflammatory cytokine levels and shorter duration of chest tube drainage.
Methods:
This pilot clinical trial enrolled nine patients (intention to treat); five completed the protocol (per protocol). Post-operative Fontan patients 20 months to 5 years receiving colchicine were compared to a previously published control cohort (n = 25). Per protocol patients received 0.6 mg colchicine daily starting post-operative day 2, ending 1 day after chest tube removal. Chest tube samples were taken on days 1–4, 7 and 10, or until removal and analysed with a 17-cytokine Bio-Plex Assay. Descriptive statistics and basic univariate comparisons were made.
Results:
There was no difference in duration of chest tube drainage or length of stay between intention to treat patients and controls. Per protocol patients had shorter duration of chest tube drainage compared to controls (6 days [interquartile range 4.7–7], versus 10 days [7–11], p = 0.007) and shorter length of stay (7 days [5.5–9] versus 9 days [9–13], p = 0.005). Pro-inflammatory cytokines trended lower in per protocol patients.
Conclusions:
In this pilot cohort, patients who completed the colchicine protocol post-Fontan procedure had shortened duration of chest tube drainage and length of stay. A decrease of pro-inflammatory cytokines may contribute to the mechanism of this change.
Although prior research has explored the demographic characteristics, religious practices, and beliefs of modern Pagans, their political attitudes and actions have yet to be studied in depth. Further, most extant research is based on non-random samples of Pagans which calls into question the generalizability of prior findings. This article examines Pagans' political attitudes and behavior using a representative sample of Pagans in the United States drawn from the 2014 Pew Religious Landscape Study. Descriptive and multivariate analyses show that Pagan religious identity shapes political views and behavior despite the varied and decentralized nature of Paganism. Overall, Pagans are relatively liberal and supportive of issues common across Pagan traditions like the environment and LGBTQ rights. However, Pagans are somewhat less politically engaged than non-Pagans as evidenced by their lower levels of party identity and voter registration.
Although political scientists have increasingly focused on the role of gender in the policy process and the characteristics of individual lobbyists, little is known about the gender politics of the government relations profession. We extend the study of professional women to the unique political context of Washington, DC, lobbying, an important form of political participation that is understudied in terms of gender. Using data from more than 25,000 individuals registered to lobby the federal government from 2008 to 2015, we show that women account for 37% of the lobbyist population in Washington, that female lobbyists are more likely to work as in-house employees than for contract lobbying firms, and that the largest Washington lobbying firms are strongly biased towards employing men. We add to these findings qualitative data from in-depth interviews with 23 lobbyists to reveal how the professional experiences of women often depend on the idiosyncrasies of lobbying employment and the political nature of their work. We conclude that the underrepresentation of women in the professional lobbying community is an underappreciated problem with broader implications for gender equality in elite political participation.
Four decades after the Court's landmark decision in Roe v. Wade, the issue of abortion persists as a point of contention for elected officials. The Catholic Church has taken a leading role in the pro-life movement, putting many Catholic representatives in a difficult position as they can be cross-pressured by their party, their constituents, and their own beliefs. Given these pressures, how do Catholic legislators explain their positions on abortion? We address this question via an analysis of public statements about abortion made by Catholic representatives and senators in the 108th Congress. We examine which members comment on abortion and use automated text analysis to measure legislators' certainty and use of moral and religious terms when discussing abortion. Multivariate analysis shows that gender, ethnicity, and an interaction between a member's position on abortion and the number of Catholics in their constituency shape how Catholic legislators discuss abortion.
Researchers commonly employ multinomial logit (MNL) models to explain individual-level vote choice while treating “abstention” as the baseline category. Though many view abstainers as a homogeneous group, we argue that these respondents emerge from two distinct sources. Some nonvoters are likely to be “occasional voters” who abstained from a given election owing to temporary factors, such as a distaste for all candidates running in a particular election, poor weather conditions, or other temporary circumstances. On the other hand, many nonvoters are unlikely to vote regardless of the current political climate. This latter population of “routine nonvoters” is consistently disengaged from the political process in a way that is distinct from that of occasional voters. Including both sets of nonvoters within an MNL model can lead to faulty inferences. As a solution, we propose a baseline-inflated MNL estimator that models heterogeneous populations of nonvoters probabilistically, thus accounting for the presence of routine nonvoters within models of vote choice. We demonstrate the utility of this model using replications of existing political behavior research.