While it has been proposed, based on epidemiological studies, that whole grains may bebeneficial in weight regulation, possibly due to effects on satiety, there is limiteddirect interventional evidence confirming this. The present cross-over study aimed toinvestigate the short-term effects on appetite and food intake of 48 g ofwhole-grain wheat (daily for 3 weeks) compared with refined grain (control). A total offourteen healthy normal-weight adults consumed, within their habitual diets, either twowhole-grain bread rolls (providing 48 g of whole grains over two rolls) or twocontrol rolls daily for 3 weeks. Changes in food intake were assessed using 7 ddiet diaries. Changes in subjective appetite ratings and food intake were also assessed atpostprandial study visits. There were no significant differences between interventions inenergy intake (assessed by the 7 d diet diaries and at the adlibitum test meal), subjective appetite ratings or anthropometric measurements.However, there was a significant difference between interventions for systolic bloodpressure, which decreased during the whole-grain intervention and increased during thecontrol intervention ( − 2 v.4 mmHg; P = 0·015). The present studyfound no effect of whole grains on appetite or food intake in healthy individuals;however, 48 g of whole grain consumed daily for 3 weeks did have a beneficialeffect on systolic blood pressure. The findings from the present study therefore do notsupport epidemiological evidence that whole grains are beneficial in weight regulation,although further investigation in other population groups (such as overweight and obese)would be required.