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At the London Tech Week event in early June, Nvidia CEO Jensen Huang praised the UK as the ‘envy of the world’ when it comes to AI researchers, but he also criticised it as the largest AI ecosystem in the world without its own infrastructure. The criticism is somewhat self-serving: when the UK does get around to building out that infrastructure, it’s certain to consist largely of chips sold by Huang’s company. It’s also unsurprising: Huang has been pitching the idea of ‘sovereign AI’ since at least 2023, conscious that nation states are the next deep pockets to target after the hyperscalers and generously funded model builders. In a world where the only real contenders in the race for AI supremacy are the US and China, we look at how the pursuit of AI sovereignty is playing out across the rest of the planet.
Vaccines have revolutionised the field of medicine, eradicating and controlling many diseases. Recent pandemic vaccine successes have highlighted the accelerated pace of vaccine development and deployment. Leveraging this momentum, attention has shifted to cancer vaccines and personalised cancer vaccines, aimed at targeting individual tumour-specific abnormalities. The UK, now regarded for its vaccine capabilities, is an ideal nation for pioneering cancer vaccine trials. This article convened experts to share insights and approaches to navigate the challenges of cancer vaccine development with personalised or precision cancer vaccines, as well as fixed vaccines. Emphasising partnership and proactive strategies, this article outlines the ambition to harness national and local system capabilities in the UK; to work in collaboration with potential pharmaceutic partners; and to seize the opportunity to deliver the pace for rapid advances in cancer vaccine technology.
It’s less than a year since OpenAI’s board voted to fire Sam Altman as CEO, in a palace coup that lasted just a weekend before Altman was reinstated. That weekend and subsequent events in OpenAI’s storyline provide all the ingredients for a soap opera. So, just in case Netflix is interested, here’s a stab at a synopsis of what might be just the first of many seasons of ‘The Generative AI Wars’.
The technical and mainstream media’s headline coverage of AI invariably centers around the often astounding abilities demonstrated by large language models. That’s hardly surprising, since to all intents and purposes that’s where the newsworthy magic of generative AI lies. But it takes a village to raise a child: behind the scenes, there’s an entire ecosystem that supports the development and deployment of these models and the applications that are built on top of them. Some parts of that ecosystem are dominated by the Big Tech incumbents, but there are also many niches where start-ups are aiming to gain a foothold. We take a look at some components of that ecosystem, with a particular focus on ideas that have led to investment in start-ups over the last year or so.
A lot has happened since OpenAI released ChatGPT to the public in November 2022. We review how things unfolded over the course of the year, tracking significant events and announcements from the tech giants leading the generative AI race and from other players of note; along the way we note the wider impacts of the technology’s progress.
Since the initial publication of A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals in 2008, the prevention of healthcare-associated infections (HAIs) has continued to be a national priority. Progress in healthcare epidemiology, infection prevention, antimicrobial stewardship, and implementation science research has led to improvements in our understanding of effective strategies for HAI prevention. Despite these advances, HAIs continue to affect ∼1 of every 31 hospitalized patients,1 leading to substantial morbidity, mortality, and excess healthcare expenditures,1 and persistent gaps remain between what is recommended and what is practiced.
The widespread impact of the coronavirus disease 2019 (COVID-19) pandemic on HAI outcomes2 in acute-care hospitals has further highlighted the essential role of infection prevention programs and the critical importance of prioritizing efforts that can be sustained even in the face of resource requirements from COVID-19 and future infectious diseases crises.3
The Compendium: 2022 Updates document provides acute-care hospitals with up-to-date, practical expert guidance to assist in prioritizing and implementing HAI prevention efforts. It is the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Disease Society of America (IDSA), the Association for Professionals in Infection Control and Epidemiology (APIC), the American Hospital Association (AHA), and The Joint Commission, with major contributions from representatives of organizations and societies with content expertise, including the Centers for Disease Control and Prevention (CDC), the Pediatric Infectious Disease Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), the Surgical Infection Society (SIS), and others.
Since the release of ChatGPT at the end of November 2022, generative AI has been talked about endlessly in both the technical press and the mainstream media. Large language model technology has been heralded as many things: the disruption of the search engine, the end of the student essay, the bringer of disinformation … but what does it mean for commercial providers of earlier iterations of natural language generation technology? We look at how the major players in the space are responding, and where things might go in the future.
It’s no secret that the commercial application of NLP technologies has exploded in recent years. From chatbots and virtual assistants to machine translation and sentiment analysis, NLP technologies are now being used in a wide variety of applications across a range of industries. With the increasing demand for technologies that can process human language, investors have been eager to get a piece of the action. In this article, we look at NLP startup funding over the past year, identifying the applications and domains that have received investment.
Mill Lodge is a 14-bed inpatient neuropsychiatric ward in Leicestershire, UK. The service primarily functions for patients with Huntington's Disease (HD), a disorder that significantly reduces life expectancy. End of Life (EoL) care is necessitated in the inpatient setting. This project therefore aims to optimise EoL care in our specialist HD unit. Specific objectives are to: establish the levels of staff confidence in dealing with EoL care; identify specific areas of EoL care that staff felt could be improved; and to introduce a series of initiatives to optimise EoL care for our patients using a QI framework.
Methods
We commenced involvement with the local QI team to develop the project. The first stage of intervention included the planning and delivery of a stakeholder event on EoL care specific to HD with the assistance of regional palliative care colleagues.
As well as our inpatient nursing and medical staff and the palliative care teams, local GPs, district nursing colleagues, speech and language therapists and psychologists attended. The session comprised an educational overview for all colleagues of HD itself and palliation was discussed at length.
The meeting also comprised an open forum where we were able to identify barriers and facilitators to optimal care from all aspects of the assembled MDT.
Results
To date our interactions have revealed that staff confidence in dealing with the different aspects of EoL care was low. This included issues with care-planning; medications; communication with patients and staff; and when to refer for specialist help.
Other processes identified as difficult included paperwork that was not consistent across teams; district nursing colleagues having to liaise with multiple medical team members to ensure continuity of care; and the doses of EoL medications required in this patient group to mitigate involuntary movements that were previously controlled with multiple high-dose oral medications.
Conclusion
Staff without specialist knowledge require support. The efforts made to improve collaboration with external colleagues broke down barriers that were preventing optimal care and allowed all parties to express their opinions and feelings. This allowed us to transparently appraise our current processes and provide guidance on this difficult area.
The journey of optimisation continues, with further practical educational interventions planned, such as syringe-driver training, and efforts to improve shared documentation and enhanced communication and collaborative working between different disciplines.
Optimal, collaborative EoL care from a confident staff-group is possible and a most important part of care for this unique patient group.
United Kingdom Health Security Agency (UKHSA) guidance related to mask use for health care workers in a non-aerosol generating procedure (AGP) setting has remained as Level 2 water repellent paper mask (surgical mask) only. Energetic respiratory events, such as coughing, can generate vast numbers of droplets and aerosols. Coughing, considered to be a non-AGP event, frequently occurs in the relatively small, confined space of an ambulance (∼25 m3). The report seeks to explore whether existing research can provide an indication of the risk to ambulance staff, via aerosol transmission, of an acute respiratory infection (ARI) during a coughing event within the clinical setting of an ambulance.
Methods:
International bibliographic databases were searched (CINAHL Plus, SCOPUS, PubMed, and CENTRAL) using appropriate search strings and a combination of relevant medical subject headings with appropriate truncation. Methodological filters were not applied. Papers without an English language abstract were excluded from the review. Grey literature was sought by searching specialist databases OpenGrey and GreyNet, as well as key organizations’ websites. The initial search identified 2,405 articles. Following screening, along with forward and backward citation of key papers identified within the literature search, 36 papers were deemed eligible for the scoping review.
Discussion:
Attempts to replicate a clinical environment to investigate the risk of transmission of airborne viruses to health care workers during a coughing event provided evidence for the generation of respirable aerosol particles and thus potential transmission of pathogens. In cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), potential to infect versus true airborne transmission is a debate that continues, but there is general consensus that a large variation of cough characteristics and aerosol generation amongst individuals exists. Studies widely endorsed face masks as a source control device, but there were conflicting views about the impact of mask leakage.
Conclusion:
Further research is required to provide clarity of the risk to health care workers when caring for a coughing patient in the confined clinical ambulance setting and to provide an evidence base to assist in the determination of appropriate respiratory protective equipment (RPE).
In the past few years, high-quality automated text-to-speech synthesis has effectively become a commodity, with easy access to cloud-based APIs provided by a number of major players. At the same time, developments in deep learning have broadened the scope of voice synthesis functionalities that can be delivered, leading to a growth in the range of commercially viable use cases. We take a look at the technology features and use cases that have attracted attention and investment in the past few years, identifying the major players and recent start-ups in the space.
Funding for AI start-ups in general is booming, and natural language processing as a subfield has not missed out. We take a closer look at early-stage funding over the last year—just over US$1B in total—for companies that offer solutions that are based on or make significant use of NLP, providing a picture of what funders think is innovative and bankable in this space, and we make some observations on notable trends and developments.
Automated writing assistance – a category that encompasses a variety of computer-based tools that help with writing – has been around in one form or another for 60 years, although it’s always been a relatively minor part of the NLP landscape. But the category has been given a substantial boost from recent advances in deep learning. We review some history, look at where things stand today, and consider where things might be going.
GPT-3 made the mainstream media headlines this year, generating far more interest than we’d normally expect of a technical advance in NLP. People are fascinated by its ability to produce apparently novel text that reads as if it was written by a human. But what kind of practical applications can we expect to see, and can they be trusted?
This essay introduces the understudied archive of early Native American poetry by reading a series of little-known poems that face the routines of ordinary life, including the observation of nature, scientific curiosity, complicity with Manifest Destiny, work, curiosity, resistance to and complicity with ideologies that exoticize Indigenous peoples, sexual anxiety, and self-critical reflection on environmental devastation. These poems speak with a shifting blend of irony, doubt, pride, political resistance or complacency, and resentment or embrace of stereotypes, while each poem also models how lyrical cultural interpretation can confront internal contradictions and competing impulses. In these ways, poetry’s capacity to represent intense literacy moves beyond colonialist, demeaning views of American Indian cultures and histories and invites us to see American Indians not only as topics of literary history but also as its creators.
It took a while, but natural language generation is now an established commercial software category. It’s commented upon frequently in both industry media and the mainstream press, and businesses are willing to pay hard cash to take advantage of the technology. We look at who’s active in the space, the nature of the technology that’s available today and where things might go in the future.
The end of the calendar year always seems like a good time to pause for breath and reflect on what’s been happening over the last 12 months, and that’s as true in the world of commercial NLP as it is in any other domain. In particular, 2019 has been a busy year for voice assistance, thanks to the focus placed on this area by all the major technology players. So, we take this opportunity to review a number of key themes that have defined recent developments in the commercialization of voice technology.
The Cassini Visual Infrared Mapping Spectrometer (VIMS) spans a wavelength range of 0.34 to 5.2 µm. Executing numerous close targeted flybys of the major moons of Saturn, as well as serendipitous flybys of the smaller moons, VIMS gathered millions of spectra of these bodies during its 13-year mission, some at spatial resolutions of a few hundred meters. The surfaces of the inner moons are dominated by water ice, while Iapetus, Hyperion, and Titan have substantial amounts of dark materials, including hydrocarbons, on their surfaces. Phoebe is grayer in color in the visible than Saturn’s other low-albedo moons. The surfaces of the inner small moons are also dominated by water ice, and they share compositional similarities to the main rings. The optical properties of the main moons are affected by particles from Saturn’s rings: the inner moons are coated by the E-ring, which originates from cryoactivity on Enceladus, while Iapetus and Hyperion are coated by particles from the Phoebe ring. Cassini VIMS detected previously unknown volatiles and organics on these moons, including CO2, H2, organic molecules as complex as aromatic hydrocarbons, nano-iron, and nano-iron oxides.