In the age of post-neoliberal globalization, complex interdependence has resulted in the integration of many economies and the industries within them and led to varied national and subnational political and economic responses. These forces have enabled the rise of a new political economy that requires the contextualized comparative sector approach (CCSA). This article advances a research agenda that contends theoretical and empirical leverage for explaining heterogeneity and assessing generalizability is gained by taking contextualized comparisons to the sector level of analysis. The CCSA identifies the multidimensional effects of sectors, uncovering new sites of inquiry connected to sectoral structural attributes, context-specific sectoral organization of institutions, and social and political constructions of sectors. Sectors are thus contexts that are embedded in multilevel contexts involving state and nonstate actors alike. Scholarship on industrial policy, technology and innovation, environmental transition, and regulation and governance demonstrates the analytical power and theoretical value of combining contextualized comparisons and sectoral analysis, which have been overlooked by the overly macro- or micro-level studies dominant in international and comparative political economy. The various strategies of the approach and a stepwise discussion of a research design underscore the possibilities for theory development and testing, adjudication of competing explanations, and case-specific discoveries.