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Resilience is a multidimensional construct. Despite being quoted as protective against mental disorders, it remains largely unexplored in our context.
Objectives
We attempted to explore the role of resilience in the development of various psychiatric symptoms as depression, anxiety and post-traumatic stress disorder following trauma in clinical population in a psychiatry outpatient of a university hospital.
Methods
We interviewed one hundred patients who sought treatment in psychiatry outpatient in a university hospital in Kathmandu, Nepal. We collected sociodemographic and trauma related information using semi-structured interview format. Other instruments used were the World Health Organization Composite International Diagnostic Interview version 2.1 for trauma categorization, the Post-Traumatic Stress Disorder Checklist-Civilian version to measure the post-traumatic stress disorder symptoms, and the 25-item Hopkins Symptom Checklist-25 to assess the level of depression and anxiety symptoms. We used Nepali adapted resilience scale derived from the original Wagnild and Young Resilience scale to measure resilience. We explored the associations between resilience scores and the scores on depression, anxiety and posttraumatic stress disorder using bivariate and multivariate analysis.
Results
Resilience had negative correlations with depression, anxiety, and post-traumatic stress disorder symptoms after adjusting for other variables such as gender, marital status, employment status, socioeconomic status and trauma types which were observed to have significant association in the bivariate analysis.
Conclusions
There was inverse correlation between resilience scores and depression, anxiety, and post-traumatic stress symptoms. Resilience should be considered in studies involving trauma population.
In recent years, evidence has started piling up that some high-energy cosmic neutrinos can be associated with blazars in flaring states. On 2022 February 26, a new blazar-neutrino coincidence was reported: the track-like neutrino event IC220225A detected by IceCube is spatially coincident with the flat-spectrum radio quasar PKS 0215+015. Like previous associations, this source was found to be in a high optical and γ-ray state. Moreover, the source showed a bright radio outburst, which substantially increases the probability of a true physical association. We have performed six observations with the VLBA shortly after the neutrino event with a monthly cadence and are monitoring the source with the Effelsberg 100m-Telescope, and with the Australia Compact Telescope Array. Here, we present first results on the contemporary parsec-scale jet structure of PKS 0215+015 in total intensity and polarization to constrain possible physical processes leading to neutrino emission in blazars.
We report the results of Long Baseline Array observations made in 2001 of ten southern sources proposed by Mattox et al. as counterparts to EGRET >100 MeV gamma-ray sources. Source structures are compared with published data where available and possible superluminal motions identified in several cases. The associations are examined in the light of Fermi observations, indicating that the confirmed counterparts tend to have radio properties consistent with other identifications, including flat radio spectral index, high brightness temperature, greater radio variability, and higher core dominance.
We present results from a multiwavelength study of the blazar PKS 1954–388 at radio, UV, X-ray, and gamma-ray energies. A RadioAstron observation at 1.66 GHz in June 2012 resulted in the detection of interferometric fringes on baselines of 6.2 Earth-diameters. This suggests a source frame brightness temperature of greater than 2 × 1012 K, well in excess of both equipartition and inverse Compton limits and implying the existence of Doppler boosting in the core. An 8.4-GHz TANAMI VLBI image, made less than a month after the RadioAstron observations, is consistent with a previously reported superluminal motion for a jet component. Flux density monitoring with the Australia Telescope Compact Array confirms previous evidence for long-term variability that increases with observing frequency. A search for more rapid variability revealed no evidence for significant day-scale flux density variation. The ATCA light-curve reveals a strong radio flare beginning in late 2013, which peaks higher, and earlier, at higher frequencies. Comparison with the Fermi gamma-ray light-curve indicates this followed ~ 9 months after the start of a prolonged gamma-ray high-state—a radio lag comparable to that seen in other blazars. The multiwavelength data are combined to derive a Spectral Energy Distribution, which is fitted by a one-zone synchrotron-self-Compton (SSC) model with the addition of external Compton (EC) emission.
The preliminary design phase of an aircraft requires quick calculation methods to assess its performance. This note develops an analytical method to obtain the optimum range and associated flight parameters for a piston-prop aircraft. The aircraft is flying so that the altitude and airspeed are kept constant.
Such a flight is called “constant altitude-constant airspeed” flight or simply “constant h-V flight”. Transport aircraft generally utilise this type of flight profile. Such a profile has been analysed by Bert for turbojet aircraft, and Hale has discussed it for both turbojet and piston-prop aircraft. This note further improves the analysis of constant h-V flight by optimising it independently and without using the known values from any other flight profile.
This report describes the clinical presentation and management of a rare case of herpes simplex virus infection in the larynx of a patient treated with methotrexate.
Case report:
We report a case of a clinically suspicious laryngeal lesion in an 82-year-old woman who started methotrexate treatment for rheumatoid arthritis. Shortly afterwards she developed dysphonia, which worsened over four months. On microlaryngoscopy, there was bilateral erythema and ulceration of the vocal folds. No other mucocutaneous lesions or systemic features were present. Biopsies revealed herpes simplex virus infection of the vocal folds; there was complete resolution with oral aciclovir. A brief literature review for this rare entity is presented and the diagnostic challenges arising from under-recognition of atypical presentations are discussed.
Conclusion:
To our knowledge, this is the first report of a rare complication of herpes simplex virus infection in the context of methotrexate-induced immunosuppression. It may present therapeutic challenges for conditions which rely on immunosuppressive treatments.
To suggest a phonosurgical management strategy that can be used for children who have previously undergone laryngotracheal reconstruction.
Methods:
This cases series describes three children who presented with complex, multi-level airway stenosis and marked dysphonia. Phonosurgical intervention involved endoscopic and open approaches, and was combined with voice therapy. A phonosurgical reconstruction management algorithm is suggested for evaluating and treating these complex conditions.
Results:
Pre-operative assessment is critical, and should involve voice analysis and glottal anatomy assessment using office laryngoscopy and stroboscopy. The risks must be weighed up against the benefit of vocal improvement. Surgical intervention should involve combined endoscopic and open approaches.
Conclusion:
Voice restoration after paediatric airway reconstruction is a complex challenge. Surgical intervention should be conducted in a step-by-step manner to reduce the risk of worsening dysphonia and airway compromise. The risks and benefits must be carefully explored and discussed.
Little information is available about perceptions of influenza vaccination of parents with healthy children in daycare. Therefore, we systematically explored the relationship between parental risk perception and influenza vaccination in children attending daycare. We distributed a self-administered paper survey to parents of children aged 6–59 months attending licensed daycare centres in Tarrant County, Texas. We used conditional logistic regression with penalized conditional likelihood to estimate odds ratios (ORs) and 95% profile likelihood confidence limits (PL) for parental risk-perception factors and influenza vaccination. A high level of parental prevention behaviours (OR 9·1, 95% PL 3·2, 31) and physician recommendation (OR 8·2, 95% PL 2·7, 30) had the highest magnitudes of association with influenza vaccination of healthy children in daycare. Our results provide evidence about critical determinants of influenza vaccination of healthy children in daycare, which could help inform public health interventions aimed at increasing influenza vaccination coverage in this population.
The successful use of virulent (lytic) bacteriophages (phages) in preventing and treating neonatal enterotoxigenic Escherichia coli infections in calves, lambs and pigs has prompted investigation of other applications of phage therapy in food animals. While results have been very variable, some indicate that phage therapy is potentially useful in virulent Salmonella and E. coli infections in chickens, calves and pigs, and in control of the food-borne pathogens Salmonella and Campylobacter jejuni in chickens and E. coli O157:H7 in cattle. However, more rigorous and comprehensive research is required to determine the true potential of phage therapy. Particular challenges include the selection and characterization of phages, practical modes of administration, and development of formulations that maintain the viability of phages for administration. Also, meaningful evaluation of phage therapy will require animal studies that closely represent the intended use, and will include thorough investigation of the emergence and characteristics of phage resistant bacteria. As well, effective use will require understanding the ecology and dynamics of the endemic and therapeutic phages and their interactions with target bacteria in the farm environment. In the event that the potential of phage therapy is realized, adoption will depend on its efficacy and complementarity relative to other interventions. Another potential challenge will be regulatory approval.
The landraces of rice (Oryza sativa L.) possess wide diversity, which needs to be properly characterized for their use in genetic improvement. Replicated field studies were conducted in 1998, 1999 and 2000 at two sites in Nepal to determine diversity in 183 landraces of rice adapted to the lowlands and the hills in Nepal. Fourteen improved genotypes were also used for comparison. Thirteen agronomic traits were investigated. Shannon–Weaver diversity index (H) and Simpson's index of diversity (D) were estimated to determine the level of genetic richness among the landraces. The landraces differed significantly for all traits. Except for plant height and maturity, at least one of the landraces compared well with the performance of improved cultivars. A principal component analysis separated the lowland- and hill-adapted landraces into two broad groups.
We have carried out a multi-wavelength study of the star forming region NGC 1893 to make a comprehensive exploration of the effects of massive stars on low mass star formation. Using deep optical U BV RI broad band, Hα narrow band photometry and slit-less spectroscopy along with archival data from the surveys such as 2MASS, MSX, IRAS and NVSS, we have studied the region to understand the star formation scenario in the region.
A photochromic tracer method has been used to record pulsatile flow velocity profiles simultaneously at three axial locations along a flow channel. Two major advantages of this multiple-trace method are that it enables velocity data to be acquired in an efficient non-invasive manner and that it provides a detailed description of the spatial relationship of the flow field. The latter is found to be particularly useful in the investigation of transitional type flows; for example, in describing coherent flow structures. Studies of the flow patterns in tubes with mild to moderate degrees of vessel constriction were performed using a 2.9 Hz sinusoidal flow superimposed on a steady flow (frequency parameter of 7.5; mean and modulation Reynolds numbers of 575 and 360, respectively). With mild constrictions (< 50% area reduction), isolated regions of vortical and helical structures were observed primarily during the deceleration phase of the flow cycle and in the vicinity of the reattachment point. As expected, these effects were accentuated when the constriction was asymmetric. For moderate constrictions (50%–80%), transition to turbulence was triggered just before peak flow through the breakdown of waves and streamwise vortices that were shed in the high-shear layer. During this vortex generation phase of the flow cycle, the wall shear stress fluctuated quite intensely, especially in the vicinity of the reattachment point, and its instantaneous value increased by at least a factor of eight. Such detailed descriptions of the transition to turbulence and of the spatial and temporal variation of the wall shear stress, particularly near the reattachment point, have not been previously reported for pulsatile flow through constricted tubes. The observed wall shear stress variations support a proposal by Mao & Hanratty (1986) of an interaction of the imposed flow oscillation with the turbulent fluctuations within the viscous sublayer.
We consider here the higher order effect of moderate longitudinal surface curvature on steady, two-dimensional, incompressible laminar boundary layers. The basic partial differential equations for the problem, derived by the method of matched asymptotic expansions, are found to possess similarity solutions for a family of surface curvatures and pressure gradients. The similarity equations obtained by this anaylsis have been solved numerically on a computer, and show a definite decrease in skin friction when the surface has convex curvature in all cases including zero pressure gradient. Typical velocity profiles and some relevant boundary-layer characteristics are tabulated, and a critical comparison with previous work is given.
Large scale (~0.6 sq deg) mapping of the giant Galactic star forming complex W 51 has been carried out simultaneously in two trans-IRAS far infrared (FIR) bands centered at ~200 and 130 μm using the TIFR 100 cm balloon borne FIR telescope. The choice of the bands is motivated by the aim of studying the emission from the cold dust (T< 30 K) component.These maps with ~1' spatial resolution, show extended emission with structures. Nearly identical beams in the two bands have enabled us to reliably determine the distribution of dust temperature T(130/200), and opticaldepth τ200, in the central region of the W 51 complex. A total of 25 discrete sources have been extracted from the 200 μmmap, of which 8 have been associated with IRAS PSC sources and 16 with sources in HIRES processed IRAS maps at 100, 60, 25 & 12 μmbands.The values of the emissivity power law index β in FIR, show wide variation among these sources.
The on-farm performance of more than 150 000 pre-basic potato (Solanum tuberosum) minitubers of 1–10 g was monitored over two years in contrasting environments in Nepal. Average minituber productivity (grams of basic seed produced per minituber planted) was 171 g in the southern plains and 116 g in the hills. Although the performance of minitubers varied between environments, minituber sizes and potato varieties, the overall results clearly indicated that minitubers can be successfully multiplied by small-scale farmers. This technology therefore allows for the highly decentralized production of basic seed which, in turn, will reduce farmers' dependence on an unreliable and costly supply of bulky conventional seed.
We report the study of ISOGAL fields in the outer galactic bulge (-1.5° < l < +1.6°, −2.6° < b < + 6.0°, area ∼ 0.42 deg2). We have combined 15 μm and 7 μm ISOCAM observations with 2MASS JHKS data to determine the nature of the sources and the interstellar extinction. Most of the ISOGAL sources show evolution of mass-loss rates in the range 3×10−8 to 1 × 10−6 (M⊙/year). Most of the detected sources are red giants above the RGB tip; a few of them show an excess in J-Ks and Ks-[15] colors. These sources are AGB stars with large mass-loss rates.
First results on AGB stars with the ISOGAL mid-infrared survey are presented. We show that M6 and later spectral type giants are detected at 7 and 15 μm up to the distance of the Galactic Centre. Analysis of the observed magnitudes and colours indicates that most of the detected AGB stars in the Galactic Bulge are losing mass. ISOCAM CVF spectra on a field in the Bulge confirm the mass loss and also show a large diversity in the shape of the silicate feature.
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