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We investigate the evolution of active galactic nucleus jets on kiloparsec-scales due to their interaction with the clumpy interstellar medium (ISM) of the host galaxy and, subsequently, the surrounding circumgalactic environment. Hydrodynamic simulations of this jet–environment interaction are presented for a range of jet kinetic powers, peak densities of the multiphase ISM, and scale radii of the larger-scale environment – characteristic of either a galaxy cluster or poor group. Synthetic radio images are generated by considering the combination of synchrotron radiation from the jet plasma and free-free absorption from the multiphase ISM. We find that jet propagation is slowed by interactions with a few very dense clouds in the host galaxy ISM, producing asymmetries in lobe length and brightness which persist to scales of tens of kpc for poor group environments. The classification of kiloparsec-scale jets is highly dependent on surface brightness sensitivity and resolution. Our simulations of young active sources can appear as restarted sources, showing double-double lobe morphology, high core prominence (CP $\gt 0.1$), and the expected radio spectra for both the inner- and outer-lobe components. We qualitatively reproduce the observed inverse correlation between peak frequency and source size and find that the peak frequency of the integrated radio spectrum depends on ISM density but not the jet power. Spectral turnover in resolved young radio sources therefore provides a new probe of the ISM.
People at high risk for psychosis access primary care mental health services for depression and anxiety and are unlikely to recover from these affective symptoms. We report the first controlled trial of cognitive–behavioural therapy (CBT) for depression and anxiety, minimally adapted for psychosis risk, in primary care.
Aims
To evaluate feasibility, acceptability and signals of efficacy for CBT for depression and anxiety adapted for psychosis risk, designed in collaboration with people with psychosis.
Method
A longitudinal controlled trial comparing best practice CBT for depression and anxiety (CBT-BP) with CBT adapted for psychosis risk (CBT-PR), in patients meeting criteria for UK primary care services and who are also clinically high risk for psychosis (trial registration no. ISRCTN40678).
Results
Rates of recruitment (55 to CBT-BP, 44 to CBT-PR), completion of measures (90% CBT-BP, 94% CBT-PR) and retention in therapy (75% CBT-BP, 95% CBT-PR) demonstrate the feasibility and acceptability of the adapted therapy. Routine measures of depression and anxiety signal improved clinical and recovery outcomes for CBT-PR. Psychosis and relational measures signal sustained improvement (at 3 months) in the CBT-PR group. No serious adverse events were reported.
Conclusions
Primary care mental health services present a unique opportunity to identify and treat people at risk of psychosis at a time when they are help-seeking. CBT for depression and anxiety, minimally adapted for psychosis risk, can be delivered in routine services, and is likely to improve clinical and recovery outcomes and reduce psychosis risk. A definitive trial is needed to estimate clinical and cost-effectiveness.
In the United States, New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Enterobacterales (CRE) are frequently associated with healthcare encounters. From September 2021 to September 2022, 21 patients with NDM-CRE identified from urine and without healthcare exposure were reported to the Centers for Disease Control and Prevention. Isolates were genetically similar to healthcare-associated strains.
Positive, negative and disorganised psychotic symptom dimensions are associated with clinical and developmental variables, but differing definitions complicate interpretation. Additionally, some variables have had little investigation.
Aims
To investigate associations of psychotic symptom dimensions with clinical and developmental variables, and familial aggregation of symptom dimensions, in multiple samples employing the same definitions.
Method
We investigated associations between lifetime symptom dimensions and clinical and developmental variables in two twin and two general psychosis samples. Dimension symptom scores and most other variables were from the Operational Criteria Checklist. We used logistic regression in generalised linear mixed models for combined sample analysis (n = 875 probands). We also investigated correlations of dimensions within monozygotic (MZ) twin pairs concordant for psychosis (n = 96 pairs).
Results
Higher symptom scores on all three dimensions were associated with poor premorbid social adjustment, never marrying/cohabiting and earlier age at onset, and with a chronic course, most strongly for the negative dimension. The positive dimension was also associated with Black and minority ethnicity and lifetime cannabis use; the negative dimension with male gender; and the disorganised dimension with gradual onset, lower premorbid IQ and substantial within twin-pair correlation. In secondary analysis, disorganised symptoms in MZ twin probands were associated with lower premorbid IQ in their co-twins.
Conclusions
These results confirm associations that dimensions share in common and strengthen the evidence for distinct associations of co-occurring positive symptoms with ethnic minority status, negative symptoms with male gender and disorganised symptoms with substantial familial influences, which may overlap with influences on premorbid IQ.
Marine litter poses a complex challenge in Indonesia, necessitating a well-informed and coordinated strategy for effective mitigation. This study investigates the seasonality of plastic concentrations around Sulawesi Island in central Indonesia during monsoon-driven wet and dry seasons. By using open data and methodologies including the HYCOM and Parcels models, we simulated the dispersal of plastic waste over 3 months during both the southwest and northeast monsoons. Our research extended beyond data analysis, as we actively engaged with local communities, researchers and policymakers through a range of outreach initiatives, including the development of a web application to visualize model results. Our findings underscore the substantial influence of monsoon-driven currents on surface plastic concentrations, highlighting the seasonal variation in the risk to different regional seas. This study adds to the evidence provided by coarser resolution regional ocean modelling studies, emphasizing that seasonality is a key driver of plastic pollution within the Indonesian archipelago. Inclusive international collaboration and a community-oriented approach were integral to our project, and we recommend that future initiatives similarly engage researchers, local communities and decision-makers in marine litter modelling results. This study aims to support the application of model results in solutions to the marine litter problem.
Background:Burkholderia multivorans are gram-negative bacteria typically found in water and soil. B. multivorans outbreaks among patients without cystic fibrosis have been associated with exposure to contaminated medical devices or nonsterile aqueous products. Acquisition can also occur from exposure to environmental reservoirs like sinks or other hospital water sources. We describe an outbreak of B. multivorans among hospitalized patients without cystic fibrosis at 2 hospitals within the same healthcare system in California (hospitals A and B) between August 2021 and July 2022. Methods: We defined confirmed case patients as patients without cystic fibrosis hospitalized at hospital A or hospital B between January 2020 to July 2022 with B. multivorans isolated from any body site matching the outbreak strain. We reviewed medical records to describe case patients and to identify common exposures. We evaluated infection control practices and interviewed staff to detect exposures to nonsterile water. Select samples from water, ice, drains, and sink splash zone surfaces were collected and cultured for B. multivorans in March 2022 and July 2022 from both hospitals. Common aqueous products used among case patients were tested for B. multivorans. Genetic relatedness between clinical and environmental samples was determined using random amplified polymorphic DNA (RAPD) and repetitive extragenic palindromic polymerase chain reaction (Rep-PCR). Results: We identified 23 confirmed case patients; 20 (87%) of these were identified at an intensive care unit (ICU) in hospital A. B. multivorans was isolated from respiratory sources in 18 cases (78%). We observed medication preparation items, gloves, and patient care items stored within sink splash zones in ICU medication preparation rooms and patient rooms. Nonsterile water and ice were used for bed baths, swallow evaluations, and ice packs. B. multivorans was cultured from ice and water dispensed from an 11-year-old ice machine in the ICU at hospital A in March 2022 but no other water sources. Additional testing in July 2022 yielded B. multivorans from ice and a drain pan from a new ice machine in the same ICU location at hospital A. All products were negative. Clinical and environmental isolates were the same strain by RAPD and Rep-PCR. Conclusions: The use of nonsterile water and ice from a contaminated ice machine contributed to this outbreak. Water-related fixtures can serve as reservoirs for Burkholderia, posing infection risk to hospitalized and immunocompromised patients. During outbreaks of water-related organisms, such as B. multivorans , nonsterile water and ice use should be investigated as potential sources of transmission and other options should be considered, especially for critically ill patients.
Background:Candida auris is a frequently drug-resistant yeast that can cause invasive disease and is easily transmitted in healthcare settings. Pediatric cases are rare in the United States, with <10 reported before 2022. In August 2021, the first C. auris case in Las Vegas was identified in an adult. By May 2022, 117 cases were identified across 16 healthcare facilities, including 3 pediatric cases at an acute-care hospital (ACH) with adult cases, representing the first pediatric cluster in the United States. The CDC and Nevada Division of Public and Behavioral Health (NVDPBH) sought to describe these cases and risk factors for C. auris acquisition. Methods: We defined a case as a patient’s first positive C. auris specimen. We reviewed medical records and infection prevention and control (IPC) practices. Environmental sampling was conducted on high-touch surfaces throughout affected adult and pediatric units. Isolate relatedness was assessed using whole-genome sequencing (WGS). Results: All 3 pediatric patients were born at the facility and had congenital heart defects. All were aged <6 months when they developed C. auris bloodstream infections; 2 developed C. auris endocarditis. One patient died. Patients overlapped in the pediatric cardiac intensive care unit; 2 did not leave between birth and C. auris infection. Mobile medical equipment was shared between adult and pediatric patients; lapses in cleaning and disinfection of shared mobile medical equipment and environmental surfaces were observed, presenting opportunities for transmission. Overall, 32 environmental samples were collected, and C. auris was isolated from 2 specimens from an adult unit without current cases. One was a composite sample from an adult patient’s bed handles, railings, tray table and call buttons, and the second was from an adult lift-assistance device. WGS of specimens from adult and pediatric cases and environmental isolates were in the same genetic cluster, with 2–10 single-nucleotide polymorphisms (SNPs) different, supporting within-hospital transmission. The pediatric cases varied by 0–3 SNPs; at least 2 were highly related. Conclusions:C. auris was likely introduced to the pediatric population from adults via inadequately cleaned and disinfected mobile medical equipment. We made recommendations to ensure adequate cleaning and disinfection and implement monitoring and audits. No pediatric cases have been identified since. This investigation demonstrates transmission can occur between unrelated units and populations and that robust infection prevention and control practices throughout the facility are critical for reducing C. auris environmental burden and limiting transmission, including to previously unaffected vulnerable populations, like children.
By emphasising the plurality of health experiences, and balancing national and transnational perspectives with the lived realities of diverse communities, this ground-breaking collection expands far beyond biomedical conceptions of health. Together, the contributors take a multi-layered view of the politics of US healthcare by examining it from historical, cultural, medical, sociological, legal, ethical and environmental perspectives. Chapters consider major health institutions and the federal policies that guide them; the intersection between health and social movements; the contours of health and illness with respect to race, gender, sexuality, age and region; and the US's often-conflicted role in global health governance.
This national pre-pandemic survey compared demand and capacity of adult community eating disorder services (ACEDS) with NHS England (NHSE) commissioning guidance.
Results
Thirteen services in England and Scotland responded (covering 10.7 million population). Between 2016–2017 and 2019–2020 mean referral rates increased by 18.8%, from 378 to 449/million population. Only 3.7% of referrals were from child and adolescent eating disorder services (CEDS-CYP), but 46% of patients were aged 18–25 and 54% were aged >25. Most ACEDS had waiting lists and rationed access. Many could not provide full medical monitoring, adapt treatment for comorbidities, offer assertive outreach or provide seamless transitions. For patient volume, the ACEDS workforce budget was 15%, compared with the NHSE workforce calculator recommendations for CEDS-CYP. Parity required £7 million investment/million population for the ACEDS.
Clinical implications
This study highlights the severe pressure in ACEDS, which has increased since the COVID-19 pandemic. Substantial investment is required to ensure NHS ACEDS meet national guidance, offer evidence-based treatment, reduce risk and preventable deaths, and achieve parity with CEDS-CYP.
In October 1781 an anonymous contributor to the London Courant – describing himself only as ‘No Fool’ – expressed his dissatisfaction with access to the latest periodicals at Peele's Coffee House. In his complaint, he explained that:
As I have a very extensive country correspondence, and wish to know what is going forward in many parts of England, I am naturally in the habit of reporting to your Coffee-house, to embrace the opportunity it affords me, in common with others, of reading the country news-papers as they arrive in town … (‘No Fool’ 1781)
While the intention of ‘No Fool’s’ letter was to chastise the behaviour of other patrons in removing the newspapers from the ‘Coffee-house’ as soon as they arrived, his brief description of accessing periodicals highlights several important themes regarding the nature of reading the news in the early modern period. First, we learn that reading the news in public settings such as coffee houses was a communal activity, taking place ‘in common with others’. Second, we learn that, in order to satiate readers’ desires to learn ‘what is going forward in many parts of England’, such institutions offered patrons a variety of newspapers and, consequently, a breadth of information concerning both local and regional matters. Third, we learn that those who were reliant upon the content of newspapers privileged the timeliness of such information. Indeed, in this author's case, it was his inability to access the newspapers immediately upon the evening ‘as they arrive[d] in town’ – instead, through the actions of others, only gaining access the following morning – that triggered his complaint.
Thinking more closely about ‘No Fool’ and his fellow readers at Peele's Coffee House, this chapter focuses upon those persons who read and consumed printed news in early modern Britain and Ireland between c. 1640 and 1800. Its focus is twofold, considering both individual ‘readers’ as well as those who consumed printed material in more structured associational groups or ‘readerships’. Turning our attention first to explore readers as individuals, the first part of this chapter draws upon current scholarship concerning the history of reading to explore crucial research questions regarding the practicalities of reading printed news in early modern Britain and Ireland.
In October 1781 an anonymous contributor to the London Courant – describing himself only as ‘No Fool’ – expressed his dissatisfaction with access to the latest periodicals at Peele's Coffee House. In his complaint, he explained that:
As I have a very extensive country correspondence, and wish to know what is going forward in many parts of England, I am naturally in the habit of reporting to your Coffee-house, to embrace the opportunity it affords me, in common with others, of reading the country news-papers as they arrive in town … (‘No Fool’ 1781)
While the intention of ‘No Fool’s’ letter was to chastise the behaviour of other patrons in removing the newspapers from the ‘Coffee-house’ as soon as they arrived, his brief description of accessing periodicals highlights several important themes regarding the nature of reading the news in the early modern period. First, we learn that reading the news in public settings such as coffee houses was a communal activity, taking place ‘in common with others’. Second, we learn that, in order to satiate readers’ desires to learn ‘what is going forward in many parts of England’, such institutions offered patrons a variety of newspapers and, consequently, a breadth of information concerning both local and regional matters. Third, we learn that those who were reliant upon the content of newspapers privileged the timeliness of such information. Indeed, in this author's case, it was his inability to access the newspapers immediately upon the evening ‘as they arrive[d] in town’ – instead, through the actions of others, only gaining access the following morning – that triggered his complaint.
Thinking more closely about ‘No Fool’ and his fellow readers at Peele's Coffee House, this chapter focuses upon those persons who read and consumed printed news in early modern Britain and Ireland between c. 1640 and 1800. Its focus is twofold, considering both individual ‘readers’ as well as those who consumed printed material in more structured associational groups or ‘readerships’. Turning our attention first to explore readers as individuals, the first part of this chapter draws upon current scholarship concerning the history of reading to explore crucial research questions regarding the practicalities of reading printed news in early modern Britain and Ireland.
Studies on predictors of outcomes of treatment for common mental health disorders (CMDs) in community mental health settings are scarce, and sample sizes are often small. Research on the impact of identifying as a member of an ethnic minority group on treatment outcomes is limited.
Aims:
To ascertain whether ethnicity is an independent predictor of outcome and the extent to which any association is mediated by other sociodemographic factors.
Method:
Retrospective observational study of anonymised treatment data collected for routine clinical purposes. Data were analysed from nine Improving Access to Psychological Therapy (IAPT) services from 2009 to 2016. Social functioning, ethnic group, age, gender, occupation and baseline severity of the mental health disorder were analysed as predictors of outcome.
Results:
Outcomes varied with ethnic group. Levels of occupation, social deprivation, initial morbidity and social functioning varied between ethnic groups at baseline. After adjustment for these factors the impact of ethnicity was attenuated and only some ethnic groups remained as significant independent predictors of treatment outcome.
Conclusions:
Ethnic minority status is a marker for multiple disadvantages. Some of the differences in outcome seen between ethnic groups may be the result of more general factors present in all ethnic groups but at greater intensity in some ethnic minority groups.
Children with genetic conditions may experience significant mental health difficulties such as anxiety and challenging behaviour. However, understanding of the feasibility and effectiveness of psychological interventions for emotional and behavioural problems in the context of genetic conditions is limited. Low-intensity psychological interventions have demonstrated promise in paediatric populations and may be able to address their mental health difficulties. A case series design was used to assess the feasibility of low-intensity interventions for emotional and behavioural difficulties in children and young people with genetic conditions recruited from a mental health drop-in centre at a tertiary hospital. Participants received seven weekly sessions with a trained practitioner. The intervention was based on existing modular treatments and evidence-based self-help materials. Feasibility and treatment satisfaction were assessed, as well as measures of symptoms of anxiety and challenging behaviour, treatment goals and quality of life, at baseline, during treatment and 6-month follow-up. Five participants received treatment for challenging behaviour, one for anxiety, and one for obsessive compulsive disorder. All participants completed treatment. Clinically significant change in the SDQ Total score was found in three participants. All participants demonstrated progress in goals and symptoms of emotional and behavioural difficulties over the course of treatment. Low-intensity psychological interventions for emotional and behavioural difficulties in children and young people with genetic conditions is feasible, acceptable and potentially beneficial. Further research is warranted to examine the effectiveness of the intervention and its use in clinical paediatric settings.
Key learning aims
(1) To gain a basic understanding of low-intensity psychological intervention in children and young people with genetic conditions.
(2) To enhance understanding of the practicalities and acceptability of delivering low-intensity psychological intervention to children and young people with genetic conditions and co-morbid emotional and behavioural difficulties.
(3) To learn about the potential clinical benefits of delivering low-intensity psychological intervention to children and young people with genetic conditions in the context of stepped care.
Acceptance that states have obligations under human rights law to take adequate steps to address the climate crisis has grown. However, discussion of how claims in this area can be adjudicated in practice has been more limited. This article outlines possible approaches that judges and other adjudicators can take, even in jurisdictions with the strongest separation of powers doctrines and where there is not yet a developed body of law in this area. Accordingly, we focus on certain minimum or ‘core’ assessment criteria that are capable of near-universal application. In this context, the terms of the landmark Paris Agreement of 2015 are key, both in setting a global temperature goal and in requiring states to ensure that their emission reductions reflect their “highest possible ambition.” We argue that this framework, together with existing due diligence principles and international scientific consensus, can provide an objective basis for assessing a state or public body’s climate policy. To illustrate this, we refer to the arguments made by Indigenous inhabitants of the Torres Strait in a pending complaint before the UN Human Rights Committee against Australia, alleging violations of the ICCPR.
American public hospitals and health centers are often criticized for their inadequate facilities or for not being patient-centred enough. Financial constraints faced by public institutions are often cited for these impediments, but government regulation also shapes the availability of good health care, with either too much or too little regulation typically impacting disproportionately upon patients whose options are limited by where they live or by the affordability of treatment. Despite the (often undervalued) endeavours of primary health care workers, many activists conclude that the system serves its own ends rather than patients’ needs – or, more polemically, that the ‘medical establishment’ poses a ‘threat to health’, as Ivan Illich famously stated in Limits to Medicine (1976). Conversely, though, health institutions are vital for preserving life and for advancing medical research, spanning a matrix of interpersonal and bureaucratic relationships which, in many ways, reflect broader changes in American society and culture. By addressing these divergent perspectives, the five authors of this section explore the politics undergirding the administration of public health institutions in terms of capacity, finances and regulation, while also reflecting historically on public–private institutional relationships, uneven efforts by authorities to tackle racial segregation in hospitals during the postwar years, and the challenges faced by the Veterans Administration in recognizing and caring for the needs of veterans facing adverse mental health experiences arising from their active service.
In assessing the role and scope of health institutions it is tempting to focus on the pace of change and technological innovations since World War II. Developments in tomography in the late 1970s and the emergence of mobile health services (or mHealth) in the 2010s, to take two examples, have offered new horizons for preserving lives. But whether we see such technological developments as complementing or straining the interpersonal bond between doctors and patients, we should remember that ‘old forms and practices coexist alongside the new’, as the 2000 volume Institutional Change and Healthcare Organizations reminds us. Sometimes owners and governing bodies are resistant to change or their organizations lack the bureaucratic agility to ensure that when change happens it is in the patients’ interest.
Questions of public health hit news headlines on a global scale when in the early months of 2020 the first cases of Covid-19 were reported in Asia, North America and Europe. A wave of earlier twenty-first-century epidemics – Zika, SARS, MERS, Ebola, H1N1 – theoretically should have equipped the global community with the surveillance strategies needed to mitigate the rapid spread of the causal virus SARS-CoV-2, which was distinctive in its high level of transmissibility and mutability, as new variants emerged during the course of 2020–22. Leading US public health officials Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, Deborah Birx, White House Coronavirus Response Coordinator, and Robert Redfield, director of the Centers for Disease Control and Prevention (CDC), were very visible on television during 2020 in presenting public health advice and data on the pandemic, whereas in other historical phases public health officials have rarely made headline news, especially over such a sustained period. The composition of the White House coronavirus response team did not mean federal agencies were coordinating seamlessly though, or that the Trump administration was fully cognizant of the need to maintain consistent public health messages in the face of a rapidly evolving emergency, caused by what Fauci called one of the most ‘unpredictable’ of viruses.
It is important to remember that the US public health system has a complex infrastructure and a considerable reach in civic life, having expanded over the course of the twentieth century via the governance and surveillance roles of the CDC and the US Public Health Service as agencies within the Department of Health and Human Services. The fact that the responsibilities of public health agencies go well beyond infectious disease control – spanning occupational health, environmental health, bioterrorism defence and health education, among other functions – shows how public health challenges are both widespread in American society and cannot be reduced to a media spectacle at times of national emergency. While sustained congressional funding of public health services to an adequate level is an ongoing concern for the scientific and medical community, the Covid-19 pandemic reveals the functional and ethical importance of such a politically independent community to ensure that health messages are accurately communicated, and to push federal and state authorities to make decisions informed by evidence-based epidemiology and robust scientific data, ideally of an evolving, granular, and comparative nature.
On 20 July 2021, four leading United States health officials addressed a congressional hearing, ‘The Path Forward: A Federal Perspective on the Covid-19 Response’, held by the US Senate Health, Education, Labor and Pensions Committee, twenty months after the novel coronavirus was first identified as a disease event in Wuhan, the capital of Hubei Province in central China. Rather than providing a conclusive review of the highly contagious SARS-CoV-2 virus that swept the United States and over two hundred countries through 2020, the committee recognized that the nation remained in a perilous state, with the Delta variant (first identified in India in December 2020) at that time causing more than 80 per cent of Covid-related illness and death among US citizens. The domestic and global politics of the hearing are evident from these basic facts about viral transmissibility and the framing of two Asian countries by many politicians and reporters as significant international health threats, despite the efforts of the World Health Organization to classify the sequence of Covid-19 variants alphabetically (Alpha to Omicron) so as not to stigmatize particular nations or peoples.
The co-chair, Senator Patty Murray, opened the hearing by highlighting the ‘promise and peril’ of this moment, and then the four health officials spoke in turn about the importance of the federal vaccination program for saving lives and containing viral spread, confirming that the most severe responses to Covid-19 were among unvaccinated Americans. The drama of the otherwise cordial hearing centred on a barbed exchange between Rand Paul, Republican senator from Kentucky and a trained ophthalmologist, and virologist Anthony Fauci, the long-standing director of the National Institute of Allergy and Infectious Diseases, who had been a key figure in the White House Coronavirus Task Force during the final year of the Trump administration and was now President Biden's Chief Medical Advisor. Instead of addressing questions of disease prevention, Rand Paul swerved to the unproven theory that the National Institutes of Health (NIH) directly funded ‘gain of function’ research at the Wuhan Institute of Virology during the 2010s, thereby making SARS-related viruses transmissible between bats and humans. Paul began by reminding Fauci that it is ‘a crime to lie to Congress’, recalling that Fauci had stated to this committee on 11 May 2021 that ‘the NIH has not ever and does not now fund gain of function research’ at the Wuhan laboratory.