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We present a method for narrowing nonparametric bounds on treatment effects by adjusting for potentially large numbers of covariates, using generalized random forests. In many experimental or quasi-experimental studies, outcomes of interest are only observed for subjects who select (or are selected) to engage in the activity generating the outcome. Outcome data are thus endogenously missing for units who do not engage, and random or conditionally random treatment assignment before such choices is insufficient to identify treatment effects. Nonparametric partial identification bounds address endogenous missingness without having to make disputable parametric assumptions. Basic bounding approaches often yield bounds that are wide and minimally informative. Our approach can tighten such bounds while permitting agnosticism about the data-generating process and honest inference. A simulation study and replication exercise demonstrate the benefits.
The sulphur microbial diet (SMD), a dietary pattern associated with forty-three sulphur-metabolising bacteria, may influence gut microbiota composition and contribute to ageing process through gut-produced hydrogen sulfide (H2S). We aimed to explore the association between SMD and biological age (BA) acceleration, using the cross-sectional study that included 71 579 individuals from the UK Biobank. The SMD score was calculated by multiplying β-coefficients by corresponding serving sizes and summing them, based on dietary data collected using the Oxford WebQ, a 24-hour dietary assessment tool. BA was assessed using Klemerae–Doubal (KDM) and PhenoAge methods. The difference between BA and chronological age refers to the age acceleration (AgeAccel), termed ‘KDMAccel’ and ‘PhenoAgeAccel’. Generalised linear regression was performed. Mediation analyses were used to investigate underlying mediators including BMI and serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio. Following adjustment for multiple variables, a positive association was observed between consuming a dietary pattern with a higher SMD score and both KDMAccel (βQ4 v. Q1 = 0·35, 95 % CI = 0·27, 0·44, P < 0·001) and PhenoAgeAccel (βQ4 v. Q1 = 0·32, 95 % CI = 0·23, 0·41, P < 0·001). Each 1-SD increase in SMD score was positively associated with the acceleration of BA by 7·90 % for KDMAccel (P < 0·001) and 7·80 % for PhenoAgeAccel (P < 0·001). BMI and AST/ALT mediated the association. The stratified analysis revealed stronger accelerated ageing impacts in males and smokers. Our study indicated a higher SMD score is associated with elevated markers of biological ageing, supporting the potential utility of gut microbiota-targeted dietary interventions in attenuating the ageing process.
Depressive and anxiety disorders constitute a major component of the disease burden of mental disorders in China.
Aims
To comprehensively evaluate the disease burden of depressive and anxiety disorders in China.
Method
The raw data is sourced from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021. This study presented the disease burden by prevalence and disability-adjusted life years (DALYs) of depressive and anxiety disorders at both the national and provincial levels in China from 1990 to 2021, and by gender (referred to as 'sex' in the GBD 2021) and age.
Results
From 1990 to 2021, the number of depressive disorder cases (from 34.4 to 53.1 million) and anxiety disorders (from 40.5 to 53.1 million) increased by 54% (95% uncertainty intervals: 43.9, 65.3) and 31.2% (19.9, 43.8), respectively. The age-standardised prevalence rate of depressive disorders decreased by 6.4% (2.9, 10.4), from 3071.8 to 2875.7 per 100 000 persons, while the prevalence of anxiety disorders remained stable. COVID-19 had a significant adverse impact on both conditions. There was considerable variability in the disease burden across genders, age groups, provinces and temporal trends. DALYs showed similar patterns.
Conclusion
The burden of depressive and anxiety disorders in China has been rising over the past three decades, with a larger increase during COVID-19. There is notable variability in disease burden across genders, age groups and provinces, which are important factors for the government and policymakers when developing intervention strategies. Additionally, the government and health authorities should consider the potential impact of public health emergencies on the burden of depressive and anxiety disorders in future efforts.
It is critical to evaluate whether the flow has transitioned into turbulence because most of the impact of large-scale mixing occurs when the flow becomes fully developed turbulence. Hydrodynamic instability flows are even more complex because of their time-dependent nature; therefore, both spatial and temporal criteria will be introduced in great detail to demonstrate the necessary and sufficient conditions for the flow to transition to turbulence. These criteria will be extremely helpful for designing experiments and numeric simulations with the goal to study large-scale turbulence mixing. One spatial criterion is that the Reynolds number must achieve a critical minimum value of 160,000. In addition, the temporal criteria suggest that flows need to be given approximately four eddy-turnover-times. This chapter will expand on these issues.
We focus on three integrated measures of the mixing: the mixed-width, mixedness, and mixed mass. I will also examine the dependence of these mixing parameters on density disparities, Mach numbers, and other flow properties. It is shown that the mixed mass is nondecreasing. The asymmetry of the bubble and spike is also discussed.
There is significant simulation and experimental evidence suggesting that hydrodynamic instability induced flows may be dependent on how the initial conditions are set up. The initial surface perturbations, density disparity, and the strength of the shockwaves could all be factors that lead to a completely different flow field in later stages.
The nonlinear stage starts when the amplitude of the unstable flow feature becomes significant. This chapter first studies the nonlinear growth of the interface amplitude and its associated terminal velocity with potential flow models, both for RM and RT. Next, one describes several models intended to predict the evolution of the bubble and spike heights, and the corresponding velocities, for the nonlinear stage. The success and limitations of each model are assessed with comparison to experiments and numerical simulations. The sensitivities to viscosity, density ratio and Mach number are discussed.
I will describe how certain external factors, such as rotation and time-dependent acceleration/deceleration, could suppress the evolution of the hydrodynamic instabilities.
By necessity, experimental studies have been the key to advancement in fluid dynamics for centuries. However, with the rapid increase of computational capabilities, numerical approaches have become an acceptable surrogate for experiments. Calculations must resolve the Navier–Stokes equations or approximate methods constructed from them. I will discuss the pros and cons of various types of approaches used, including direct numerical simulations, subgrid models, and implicit grid-discretization-based large-eddy simulation.
This chapter contains a discussion of the coupling of a magnetic field, through the framework of magnetohydrodynamics (MHD), to the hydrodynamic body forces. This leads to an additional body force, namely the Lorentz force on electrical currents in the fluid. Due to their conductivity, this effect is especially important for ionized plasmas. The intuitive result is that the magnetic field lines follow the flow, and they have an effective tension that can stabilize the RTI. As with the RTI, the RMI can be suppressed by a magnetic field.
The challenge confronting researchers is significant in many ways. One can start by noting that multiple instabilities might exist simultaneously and interact with each other. As an example, oblique shocks generate all three instabilities: RT, RM, and KH. In this chapter, several combined instabilities are discussed: RTI and RMI, RTI and/or RMI with KHI.
In this chapter, we will focus on the statistical spectral dynamics which are paramount to understanding the development of the integrated mixing quantities described in Chapter 5. Reynolds flow averaging and the turbulent kinetic energy are introduced. In addition, I will discuss how the energy of the flows is transferred from large scale to small scale modes, as well as the impact of the shockwave and gravity on the isotropy of the flows. The flow spectra allow several important length scales to be defined. Numeric simulations and experimental data will be offered to provide insights on the mixing processes.
This chapter will provide a detailed presentation of the basic structure of the supernova and its core collapse process to illustrate the roles that RMI, RTI, and KHI play in the different stages of these processes. During the explosions, the shockwave passing through the onion-like supernova core will generate both RMI and RTI. The RTI is the key physical process creating the filament structures observed in the Crab Nebula. MHD RT instabilities will be presented to show how they can further improve the comparison between simulations and observations. Several additional applications where hydrodynamic instability plays an important role will also be examined. Geophysics and solar physics also present effective lenses to view the importance of hydrodynamic instabilities. In the case of solar physics, I will describe how RTI’s impact can be viewed through various phenomena, such as the plumes that rise from low density bubbles as well as eruptions that occur as material returns to the solar surface. Once again, MHD RT instabilities are relevant.
After the RM instability grows from a first shock, it can be hit by a second shock. These reshock scenarios have been found in the key applications of inertial confinement fusion implosions or supernova explosions. In this chapter, I will introduce the efforts to model the growth of the mixing layer induced by the first shock and subsequent reshock and describe how the turbulence kinetic energy and anisotropy might be affected by the reshock events. Data from shock tube experiments and numeric simulations will also be introduced to provide insight into the reshock RM induced flows.