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Persistent pulmonary hypertension of the newborn is a serious disease with significant morbidity and mortality. Magnesium sulphate has been proposed as a potential treatment for persistent pulmonary hypertension of the newborn, but its efficacy remains unclear. The article aims to evaluate the effects of magnesium sulphate on persistent pulmonary hypertension of the newborn.
Methods:
A comprehensive search of PubMed, Web of Science, Embase, and Cochrane Library was conducted to identify relevant studies. The primary outcomes were pulmonary artery pressure and oxygenation index, while secondary outcomes included mean blood pressure, alveolar-arterial oxygen difference, arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and arterial oxygen saturation. Statistical analysis was performed by Cochrane Review Manager 5.3.
Results:
The study analysed twelve studies involving 380 patients. Results indicated that magnesium sulphate treatment significantly reduced pulmonary artery pressure levels (MD −24.96, 95% CI −28.19 to −21.73, P < 0.0001) and mean blood pressure (MD −3.11, 95% CI −3.91 to −2.32, P < 0.0001) compared to pretreatment. Additionally, it led to a notable decrease in oxygenation index (P < 0.00001) and alveolar-arterial oxygen difference (P < 0.0001), while increasing PaO2 (P < 0.0001) and arterial oxygen saturation (P < 0.001). However, there was no significant effect on PaCO2 levels compared to pretreatment.
Conclusion:
Magnesium sulphate is a valuable therapy for persistent pulmonary hypertension of the newborn. It markedly reduced pulmonary artery pressure, alveolar-arterial oxygen difference, and oxygenation index, while enhancing PaO2, and arterial oxygen saturation, with no impact on PaCO2 levels. Magnesium sulphate may also reduce mean blood pressure following a 2-hour treatment. Additional studies are necessary to further clarify its efficacy and potential side effects.
Registration:
This study was registered with PROSPERO (CRD42024578092).
This chapter examines the critical role of evaluation within the framework of recommender systems, highlighting its significance alongside system construction. We identify three key aspects of evaluation: the impact of metrics on optimization quality, the collaborative nature of evaluation efforts across teams, and the alignment of chosen metrics with organizational goals. Our discussion spans a comprehensive range of evaluation techniques, from offline methods to online experiments. We explore offline evaluation methods and metrics, offline simulation through replay, online A/B testing, and fast online evaluation via interleaving. Ultimately, we propose a multilayer evaluation architecture that integrates these diverse methods to enhance the scientific rigor and efficiency of recommender system assessments.
The introduction of advanced deep learning models such as Microsoft’s Deep Crossing, Google’s Wide&Deep, and others like FNN and PNN in 2016 marked a significant shift in the field of recommender systems and computational advertising, establishing deep learning as the dominant approach. This chapter discusses the evolution of traditional recommendation models and highlights two main advancements in deep learning models: enhanced expressivity for uncovering hidden data patterns and flexible model structures tailored to specific business use cases. Drawing on techniques from computer vision, speech, and natural language processing, deep learning recommendation models have rapidly evolved. The chapter summarizes several influential deep learning models and constructs an evolution map. These models are selected based on their industry impact and their role in advancing deep learning recommender systems. Additionally, the chapter will introduce applications of Large Language Models (LLMs) in recommender systems, exploring how these models further enhance recommendation technologies.
This chapter explores the integration of deep learning in recommender systems, highlighting its significance as a leading application area with substantial business value. We examine notable advancements driven by industry leaders like Meta, Google, Airbnb, and Alibaba. These innovations mark a transformative shift toward deep learning in recommender systems, evidenced by Alibaba’s ongoing innovations in e-commerce and Airbnb’s applications in search and recommendation. For aspiring recommender system engineers, the current era of open-source code and knowledge sharing provides unparalleled access to cutting-edge applications and insights from industry pioneers. This chapter aims to build a foundational understanding of deep learning recommender systems developed by Meta, Airbnb, YouTube, and Alibaba, encouraging readers to focus on technical details and engineering practices for practical application.
This concluding chapter revisits the overarching architecture of recommender systems, encouraging readers to synthesize the technical details discussed throughout the book into a cohesive knowledge framework. Initially introduced in Chapter 1, the technical architecture diagram serves as a foundational reference for understanding the field. With a comprehensive overview of each module now complete, readers are invited to refine their interpretations of the architecture. Establishing a personal knowledge framework is crucial for identifying gaps, appreciating details, and maintaining a holistic view of the subject.
Embedding technology plays a pivotal role in deep learning, particularly in industries such as recommendation, advertising, and search. It is considered a fundamental operation for transforming sparse vectors into dense representations that can be further processed by neural networks. Beyond its basic role, embedding technology has evolved significantly in both academia and industry, with applications ranging from sequence processing to multifeature heterogeneous data. This chapter discusses the basics of embedding, its evolution from Word2Vec to graph embeddings and multifeature fusion, and its applications in recommender systems, with an emphasis on online deployment and inference.
Recommender systems have evolved significantly in response to growing demands, progressing from early methods like Collaborative Filtering (CF) and Logistic Regression (LR) to more advanced models such as Factorization Machines (FM) and Gradient Boosting Decision Trees (GBDT). Since 2015, deep learning has become the dominant approach, leading to the development of hybrid and multimodel frameworks. Despite the rise of deep learning models, traditional recommendation methods still hold valuable advantages due to their interpretability, efficiency, and ease of deployment. Furthermore, these foundational models, such as CF, LR, and FM, form the basis for many deep learning approaches. This chapter explores the evolution of traditional recommendation models, detailing their principles, strengths, and influence on modern deep learning architectures, offering readers a comprehensive understanding of this foundational knowledge.
Building an effective recommender system requires more than just a strong model; it involves addressing a range of complex technical issues that contribute to the overall performance. This chapter explores recommender systems from seven distinct angles, covering feature selection, retrieval layer strategies, real-time performance optimization, scenario-based objective selection, model structure improvements based on user intent, the cold start problem, and the “exploration vs. exploitation” challenge. By understanding these critical aspects, machine learning engineers can develop robust recommender systems with comprehensive capabilities.
Recommender systems have become deeply integrated into daily life, shaping decisions in online shopping, news consumption, learning, and entertainment. These systems offer personalized suggestions, enhancing user experiences in various scenarios. Behind this, machine learning engineers drive the constant evolution of recommendation technology. Described as the “growth engine” of the internet, recommender systems play a critical role in the digital ecosystem. This chapter explores the role of these systems, why they are essential, and how they are architected from a technical perspective.
While previous chapters discussed deep learning recommender systems from a theoretical and algorithmic perspective, this chapter shifts focus to the engineering platform that supports their implementation. Recommender systems are divided into two key components: data and model. The data aspect involves the engineering of the data pipeline, while the model aspect is split between offline training and online serving. This chapter is structured into three parts: (1) the data pipeline framework and big data platform technologies; (2) popular platforms for offline training of recommendation models like Spark MLlib, TensorFlow, and PyTorch; and (3) online deployment and serving of deep learning recommendation models. Additionally, the chapter covers the trade-offs between engineering execution and theoretical considerations, offering insights into how algorithm engineers can balance these aspects in practice.
Recommender systems are ubiquitous in modern life and are one of the main monetization channels for Internet technology giants. This book helps graduate students, researchers and practitioners to get to grips with this cutting-edge field and build the thorough understanding and practical skills needed to progress in the area. It not only introduces the applications of deep learning and generative AI for recommendation models, but also focuses on the industry architecture of the recommender systems. The authors include a detailed discussion of the implementation solutions used by companies such as YouTube, Alibaba, Airbnb and Netflix, as well as the related machine learning framework including model serving, model training, feature storage and data stream processing.
Prior research on status has focused primarily on the cognitive perspective, exploring the effects of status and offering a limited understanding of the impact of positive status change and its emotional mechanisms. This study draws upon the two-facet model of pride to examine how positive status change influences the behaviors of new status holders. Specifically, we propose that when status differentiation is low, positive status change enhances new status holders' prosocial behavior through their authentic pride, while in cases of high status differentiation, it increases their self-interested behavior through their hubristic pride. To test our hypotheses, we conducted a series of studies, including a laboratory experiment, a scenario experiment, and a time-lagged multilevel and multisource field study. Our multilevel analyses of the data provided strong support for our hypotheses. Our findings shed light on when and why positive status change triggers different behaviors among new status holders, offering important insights into the emotional mechanisms that underlie the effects of status change.
This paper explores the international higher education (IHE) fever gripping China's middle-class families. Drawing on data gathered from 69 qualitative interviews with Chinese middle-class international students whose education is financially supported by their families, the paper points out that the desire for IHE is influenced by the pursuit of the “normative biography,” a term conceptualized by the authors to refer to the societal expectations that prescribe the specific life milestones and sequences that young middle-class adults should follow on their life trajectories. IHE is perceived as an important pathway to help such young adults meet these social expectations. Moreover, parental support for IHE is not only an educational investment but also assists offspring in conforming to the normative biography. This paper enriches the understanding of how educational practices are influenced by broader sociocultural contexts in contemporary China.
Understanding the genetic basis of porcine mental health (PMH)-related traits in intensive pig farming systems may promote genetic improvement animal welfare enhancement. However, investigations on this topic have been limited to a retrospective focus, and phenotypes have been difficult to elucidate due to an unknown genetic basis. Intensively farmed pigs, such as those of the Duroc, Landrace, and Yorkshire breeds, have undergone prolonged selection pressure in intensive farming systems. This has potentially subjected genes related to mental health in these pigs to positive selection. To identify genes undergoing positive selection under intensive farming conditions, we employed multiple selection signature detection approaches. Specifically, we integrated disease gene annotations from three human gene–disease association databases (Disease, DisGeNET, and MalaCards) to pinpoint genes potentially associated with pig mental health, revealing a total of 254 candidate genes related to PMH. In-depth functional analyses revealed that candidate PMH genes were significantly overrepresented in signaling-related pathways (e.g., the dopaminergic synapse, neuroactive ligand‒receptor interaction, and calcium signaling pathways) or Gene Ontology terms (e.g., dendritic tree and synapse). These candidate PMH genes were expressed at high levels in the porcine brain regions such as the hippocampus, amygdala, and hypothalamus, and the cell type in which they were significantly enriched was neurons in the hippocampus. Moreover, they potentially affect pork meat quality traits. Our findings make a significant contribution to elucidating the genetic basis of PMH, facilitating genetic improvements for the welfare of pigs and establishing pigs as valuable animal models for gaining insights into human psychiatric disorders.