This essay examines the challenges and possibilities of mobilizing the African Diaspora as the African Union’s “6th Region,” drawing on the author’s diplomatic experience as Ghana’s Ambassador to Brazil accredited to twelve South American states. Using the Sankofa symbol as a conceptual framework, the paper explores the historical complexity of the African Diaspora, distinguishing among multiple diasporic formations shaped by migration, exile, and the transatlantic slave trade. It assesses institutional tensions between diaspora communities, civil society organizations, and formal structures of the African Union, in relation to the Pan-African Congresses and nation-state representation, arguing for stronger transnational engagement, institutional clarity, and sustained educational and cultural exchange to strengthen Global African solidarity.