This research explores the integration of regional markets for 21 food commodities in Ghana. Utilizing co-integration tests and autoregressive distributed lag models, it investigates price linkages and market responsiveness, also considering the impact of telecommunications and road infrastructure. The study reveals that markets generally adjust quicker to price increases than decreases, with disparities noted in specific regions and commodities. It emphasizes the importance of improving internet speeds and road quality to enhance market integration, suggesting policy measures to sustain and optimize agri-food networks amid global disruptions.