The Climate Change Anxiety Scale (CCAS), developed by Clayton and Karazsia (2020), assesses the negative emotional impact of climate change on well-being. However, its psychometric properties have not yet been sufficiently explored for Spanish spoken in Spain and Spanish culture. This research introduces the Spanish version of the CCAS (CCAS–S), examines its psychometric properties, and provides validity evidence supporting its intended purpose. Two studies were conducted: first, the original version of the CCAS was translated into Spanish using a committee approach to translation design; second, 806 participants completed the CCAS–S along with additional assessment instruments to gather validity evidence. The 13-item Spanish version showed adequate reliability and internal structure validity evidence for the two-dimensional model, aligning with theoretical expectations. Nevertheless, a refined 10-item version distinguishing metacognitive impairment, emotional distress, and functional interference dimensions optimized the scale’s intended purpose. The study discusses the conditions for using the CCAS–S measures and its practical implications.