The 2022 and 2025 floods in Pakistan forced more than 33 million people to flee from their homes, destroyed medical facilities across a large portion of Punjab, Khyber-Pakhtunkhwa, Sindh, and Balochistan, and revealed major deficiencies in government management, healthcare systems, environmental protection, and climate preparedness. Pakistan emits <1% of worldwide greenhouse gases, yet remains among the most climate-sensitive nations, reflecting global inequities in climate impact. Floods destroyed basic health determinants, thus contributing to infectious disease epidemics, malnutrition, and mental health problems. To evaluate the short- and long-term flood impacts, this article applies the Disaster Management Cycle, along with the One Health, Planetary Health, and Doughnut Economy frameworks. The framework demonstrates the impact of floods on the health and healthcare system while simultaneously eroding the ecosystem and making the population more susceptible. The article identifies priorities for climate-adaptive health care infrastructure, environmental recovery, equity-centered disaster preparedness, and integration of One Health principles into medical education.