Purple witchweed is a hemiparasitic plant that significantly affects sorghum yields in semiarid regions. It also affects crops such as corn, millets, and rice. Developing purple witchweed-resistant sorghum varieties is an essential element in integrated purple witchweed management. This study evaluated the response of 48 sorghum genotypes to purple witchweed grown both in pots and in field conditions. Resistant varieties (Berhan and Framida) and susceptible varieties (Assosa-1, Adukara, and ETSL102967) were used as controls. The findings revealed substantial variability among the sorghum landraces in their response to purple witchweed. Purple witchweed density was less when seeds were grown with early maturing sorghum genotypes, while late-maturing genotypes were more susceptible to the weed. Notably, the ETSL102969 landrace showed strong resistance, comparable to that of Berhan. Additionally, the ETSL102970 landrace demonstrated superior resistance to purple witchweed compared to Framida. Based on these results, ETSL102969 and ETSL102970 are recommended as valuable sources of resistance for breeding programs aiming to improve sorghum resistance against purple witchweed in Ethiopia.

Whole-body and regional raw bioelectrical impedance analysis (BIA) parameters have been used to develop lean soft tissue estimation prediction models. Still, no regional fat mass (FM) assessment models have been provided. Hence, we aimed to develop and validate BIA-derived equations to predict regional FM against dual-energy X-ray absorptiometry (DXA) in healthy adults. One hundred and forty-eight adults (77 females) were included in this cross-sectional investigation. DXA assessed whole-body and regional FM and raw bioelectrical parameters of distinct body regions were measured using a 50 kHz phase-sensitive BIA analyser. BIA-derived equations were developed for each sex using a stepwise multiple linear regression approach in 2/3 of the sample and cross-validated in the remaining sample. The BIA-derived equations exhibited moderate to very strong relationships (P < 0·001) with DXA-measured FM of all body regions in females (r = 0·650 to 0·907) and males (r = 0·401 to 0·807). Also, for all the models, no significant deviation from linearity was found (P > 0·10). Agreement analyses revealed no associations between the differences and the means of the predicted and DXA-derived FM. However, the limits of agreement were large, with individual errors exceeding 50 % in females and 70 % in males. While the new BIA-derived equations provide a valid estimate of regional FM in middle-aged healthy adults at the population level, demonstrating a cost-effective alternative to DXA for assessing regional FM, caution is advised when applying these equations for individual-level analysis.

This article analyses the depictions of immunity and immunological functions employed in proprietary medical advertising in British newspapers between 1890 and 1940. Using marketing copy to gain insights into the ways immunity was presented to the public and normalised outside of medical institutions and publications, I offer four main areas of discussion. First, I present an analysis of the ways advertisements evoked both natural and artificial immunity in their marketing copy, thereby affording us insights into the ways immunity was made palatable both to those supportive of and opposed to vaccinations. I then unpack the ways in which this advertising copy often emphasised immunity rather than the immunological, that is, presented immunity as resistance to infection achieved by purchasing particular brands, rather than as part of a defensive process taking place at a cellular level. Third, I examine the ways in which advertisements engaged with futurity and drew on a narrative of social exclusion that pitted created communities of the immune against the non-immune. Finally, I analyse the ways in which immunity was used to connect the biological and the psychological, looking particularly at the ways immunity against worry was sold to the public.

This article addresses recent work on empire and colonisation which calls for a reappraisal of how agency and resistance manifests among groups responding to structural marginalisation. We argue that approaching these questions from within the colonial order reveals important idiosyncrasies regarding how groups understood resistance, agency, and popular organising as possible responses that emerged from within imperial landscapes. Using the example of race as a central regulatory category and practice of colonial power, we analyse two cases which we suggest benefit from an account of agency and resistance within colonial order: the Black Loyalists in English America and the Indigenous royalists of New Granada, two groups which pursued emancipation by choosing to remain under colonial rule. The resulting analysis produces a more dynamic account of resistance and emancipation which responds to the far-reaching influence of colonial order for resistance movements at local, national, and international levels. This account contributes to recent debates which call for theoretical analysis of “middle actors” and popular thinking as it relates to international politics, postcolonial movements, and studies of empire.

Systematically monitoring the baseline sensitivity of troublesome weeds to herbicides is a crucial step in the early detection of their market lifespan. Florpyrauxifen-benzyl is one of the most important herbicides used in rice production throughout the world, and has been used for 5 yr in China. Barnyardgrass is one of the main targeted weed species of florpyrauxifen-benzyl. In total, 114 barnyardgrass populations were collected from rice fields in Jiangsu Province, China, and using whole-plant bioassays they were screened for susceptibility to florpyrauxifen-benzyl. The GR50 values (representing the dose that causes a 50% reduction in fresh weight of aboveground parts) of florpyrauxifen-benzyl for all populations ranged from 1.0 to 34.5 g ai ha−1, with an average of 6.8 g ai ha−1, a baseline sensitivity dose of 3.3 g ai ha−1, and a baseline sensitivity index of 34.5. Twenty-one days after treatment with florpyrauxifen-benzyl at the labeled dose (36 g ai ha−1), 90% of the barnyardgrass populations exhibited >95% reductions in fresh weight of aboveground parts. Compared with the baseline sensitivity dose, 63, 44, and 7 populations had, respectively, no resistance (55%), low resistance (39%), and moderate resistance (6%) to florpyrauxifen-benzyl. Furthermore, the GR50 distribution of barnyardgrass populations did not show a significant correlation with collection location, planting method (direct-seeding or transplanting), or rice species (Oryza sativa L. ssp. indica or ssp. japonica) at any of rice fields where seeds had been collected (P > 0.05). In conclusion, florpyrauxifen-benzyl remains effective for barnyardgrass control in rice fields despite serious resistance challenges.

Plant secondary metabolites (PSMs) may improve gastrointestinal health by exerting immunomodulatory, anti-inflammatory and/or antiparasitic effects. Bark extracts from coniferous tree species have previously been shown to reduce the burden of a range of parasite species in the gastrointestinal tract, with condensed tannins as the potential active compounds. In the present study, the impact of an acetone extract of pine bark (Pinus sylvestris) on the resistance, performance and tolerance of genetically diverse mice (Mus musculus) was assessed. Mice able to clear an infection quickly (fast responders, BALB/c) or slowly (slow responders, C57BL/6) were infected orally with 200 infective third-stage larvae (L3) of the parasitic nematode Heligmosomoides bakeri or remained uninfected (dosed with water only). Each infection group of mice was gavaged for 3 consecutive days from day 19 post-infection with either bark extract or dimethyl sulphoxide (5%) as vehicle control. Oral administration of pine bark extract did not have an impact on any of the measured parasitological parameter. It did, however, have a positive impact on the performance of infected, slow-responder mice, through an increase in body weight (BW) and carcase weight and reduced feed intake by BW ratio. Importantly, bark extract administration had a negative impact on the fast responders, by reducing their ability to mediate the impact of parasitism through reducing their performance and tolerance. The results indicate that the impact of PSMs on parasitized hosts is affected by host's genetic susceptibility, with susceptible hosts benefiting more from bark extract administration compared to resistant ones.

Sulfadoxine-pyrimethamine (SP) is the standard of care for Plasmodium falciparum malaria chemoprevention among pregnant women, infants and children. Developing alternative chemoprevention products and other prevention products, such as vaccines and monoclonal antibodies, requires significant investment. However, knowledge gaps surrounding the activity of SP and resistance put these investments at risk. Therefore, we reviewed SP’s combined antimalarial action, including the individual antiplasmodial components, other antimicrobial effects, impact on malaria immunity development and continued effectiveness in settings with high SP resistance. We created a roadmap of non-clinical and clinical evidence to better understand the effectiveness of SP for chemoprevention and inform the development of new prevention tools.

The role that Roma communities played in the Resistance during the Second World War is a little-known part of history, especially in Italy. Through consideration of their involvement, we can highlight the complexity of the Resistance, and recognise Roma communities as an integral part of Italian society. Roma involvement in the Resistance had distinctive characteristics compared to that of the gagi (non-Roma), particularly in how they viewed it not only as a fight against fascism, but also it as a means of honouring the mulé (the dead). However, only a handful of Roma partisans are recorded in the Ricompart archive, which contains documentation relating to those who participated in Resistance activities. To trace history, personal testimony, in addition to secondary historiography, is key. Roma communities share a rich oral tradition, which forms the basis of a significant part of this article, and which offers an account of civil resistance and armed action both within partisan groups and as part of small formations based on ethnicity. This piece examines the reasons why the Roma partisans who fought and died in the Resistance did not receive full public recognition, a form of historical amnesia of the postwar period rooted in the absence of a cultural ‘defascistisation’ whereby fascist-style racism permeated the Republic.