In this study, we present a low-numerical-aperture (NA) confined-doped fiber architecture that synergistically mitigates transverse mode instability (TMI) through combined optical waveguide engineering and spatially tailored gain distribution. The individual and combined benefits of low-NA fiber design and the confined-doped fiber design strategy on TMI mitigation are numerically investigated. Building upon these theoretical analyses, a self-developed fiber, featuring a core/cladding diameter of approximately 26/400 μm, a core NA of approximately 0.045 and a core doping ratio of approximately 75%, is fabricated. Further experimental validation in a master oscillator power amplifier demonstrates 6.74 kW output power with near-single-mode (M
${}^2\sim$1.49) beam quality, validating the design’s efficacy. This study establishes a novel fiber design paradigm that concurrently addresses TMI mitigation, beam quality maintenance and power scalability, offering a viable pathway toward robust high-power fiber laser sources with near-diffraction-limited beam quality.