Management of broadleaf weeds in chile pepper may be improved by including a rotation with sorghum treated with selective, non-residual herbicides. However, herbicides applied to sorghum specifically for managing weeds in subsequent chile pepper crops have not been evaluated. This study evaluated two herbicide treatments applied to sorghum for their effects on broadleaf weed density and hand hoeing time in chile pepper crops the following year, and compared the treatments for their net economic benefits across sorghum and chile pepper growing seasons. Treatments included 1) a sorghum nontreated control; 2) one herbicide application, which was a premix combination of 2,4-D (0.35 kg ai ha−1), bromoxynil (0.35 kg ai ha−1), and fluroxypyr (0.14 kg ai ha−1) applied at the 4-leaf stage of sorghum; 3) two herbicide applications, which included the aforementioned premix combination followed by bromoxynil (0.28 kg ai ha−1) applied at the 6-leaf stage of sorghum; and 4) weed-free sorghum using hand hoeing. Results indicated that broadleaf weeds covered less than 10% of the ground where sorghum had been treated with herbicides. The two-application treatment resulted in 24% fewer broadleaf weeds in chile pepper than in sorghum that had been hoed by hand, and 63% fewer than the one-application treatment. Hand hoeing time for chile pepper was similar among the two-application treatment, one-application treatment, and weed-free sorghum. A partial budget analysis indicated that the one-application treatment provided greater net economic benefit than the two-application treatment (US$6,550 ha−1 vs. US$5,894 ha−1), due to lower input costs and greater overall gross revenue. These findings indicate that a two-application treatment maximizes reductions of broadleaf weeds in chile pepper caused by rotational sorghum; however, the one-application treatment may be a cost-effective approach to reducing broadleaf weeds in chile pepper.