This paper studies the effects of the U.S. railroad expansion during the 19th century on exports of wine at the customs district level. I digitize previously unexploited data on wine trade flows for customs districts from 1870 to 1900 and combine these data with GIS-based measures of access to wine-producing regions for each district. I find that improved access to wine producers, driven by the ongoing construction of more railways, led to districts exporting more wine. My results suggest that the rollout of the U.S. railroad network had important effects on the spatial distribution of the wine trade across ports.