As negotiations on the Global Plastics Treaty progress, the extent to which reuse is embedded in the Treaty will serve as an indicator of its ambition to transform plastic systems rather than merely manage their waste outputs. Reuse is one of the most powerful yet underutilised interventions to achieve circularity, and is essential for reducing plastic production, lowering emissions and disrupting the dominance of single-use models. However, the current Treaty text reflects only limited and ambiguous references to reuse, often coupled with recycling, raising concerns that this cornerstone of circularity is at risk of being sidelined. This article argues that the Treaty’s effectiveness, both as a regulatory instrument and as a tool for transformation, will depend on whether it embeds the enabling conditions required to make reuse viable at scale. Drawing on recent research by the Global Plastics Policy Centre, we explore two core areas where progress is urgently needed: first, the limitations of setting numerical reuse targets without the underlying systems, infrastructure and regulatory clarity needed to implement them; and second, the persistent structural and regulatory barriers that prevent reuse systems from scaling. Without system-wide enablers, the Treaty risks repeating the common policy pattern of prioritising headline commitments over operational feasibility. Numerical targets, while politically attractive and symbolically important, do not create the conditions needed for sustained reuse uptake. Effective systems require regulatory mandates alongside design standards, infrastructure investment and mechanisms for tracking performance and ensuring compliance. At the global level, structural barriers include divergent regulations, inconsistent standards, a lack of harmonised definitions and metrics and financing systems that favour single use. Extended producer responsibility schemes, still skewed towards recycling, have not adequately incentivised reuse. The Treaty presents an opportunity to address these barriers through common standards and policy signals that support reuse as the default. To realise reuse as a transformative pillar of circularity, the Treaty must go beyond aspiration and commit to building the conditions under which reuse can thrive, which would shift plastics governance towards systems that value durability, more equitable responsibility and reform.