We present an experimental study on electron and X-ray generation from the interaction of a hundreds of TW femtosecond laser with microchannels. Leveraging the guiding effect of the channel structure on both the laser and electrons, a well-collimated electron beam is achieved, with a beam charge of 1.5 nC (>10 MeV), a slope temperature of 9.1 MeV and a nearly constant divergence angle (~14°) over a broad energy range (10–50 MeV). Meanwhile, we demonstrate a ring-shaped X-ray source generated through bremsstrahlung radiation mechanism from electrons collision with channel walls, exhibiting a characteristic energy of 90 keV and emittance of 0.8 mm mrad. Three-dimensional simulations elucidate the underlying acceleration dynamics. It is found that elongated channels facilitate the formation of well-collimated electron beams. These results establish the foundation for applications of channel guided electrons and secondary radiation sources and represent a key step toward the controlled manipulation of particle sources in laser-driven plasmas.