Glucagon-like peptide-1 (GLP-1) medications are changing consumers’ appetites. Little is known about how GLP-1 use is associated with U.S. meal location choices and protein preferences. Using meal reporting from a consumer survey and a random parameters logit model, we examine associations between GLP-1 use, duration of use, meal location choices, and protein preferences. Results indicate that GLP-1 users differ substantially from non-users in their outlet choices, meal skipping rates, and certain protein preferences. These differences are most prominent among shorter-term users. Our findings highlight notable patronage patterns associated with GLP-1 use, with implications for food retailers and opportunities for foodservice.