This study examines continuity and changes across contextual insecurities (intimate partner violence, material hardship) and relational adversities (parenting stress, maternal depression) from infancy to preschool years and explores their long-term influence on young adults’ mental health at age 22. The sample was drawn from the Future of Families and Child Wellbeing Study (N = 4,677; 52.3% male, 21.2% White, 47.77% Black, 27.15% Latinx, 3.88% Other). The multidimensional growth mixture model identified five trajectory classes: Low Adversity, High-Stable Parenting Stress, High-Increasing Material Hardship, High-Decreasing IPV, and Multidimensional Persistent Adversity. Young adults in the Multidimensional Persistent Adversity and High-Decreasing IPV classes reported higher depression and anxiety than those in the Low Adversity or High-Stable Parenting Stress classes. Findings highlight the need for tailored early intervention to alleviate chronic and multidimensional adversities within family systems. It also emphasizes implementing trauma-informed intervention programs to support emerging adults’ mental health and thriving.