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Chapter 3 - The Endocannabinoids

from Section 1 - An Introduction to Cannabinoid Science

Published online by Cambridge University Press:  12 October 2020

Steven James
Steven James
Affiliation:
University of California, San Diego
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Summary

As we have discussed previously in Chapters 1 and 2, cannabinoids have been very difficult to isolate and study due to their significant lipophilic properties. Once it was finally determined that (-)Δ9-tetrahydrocannabinol (THC) was the psychoactive component in cannabis (Gaoni and Mechoulam, 1964), attention quickly focused on understanding how THC worked in the brain. Many believed cannabinoids acted directly on membranes and did not bind specifically to receptors because of the high lipophilicity of THC.

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A Clinician's Guide to Cannabinoid Science , pp. 27 - 40
Publisher: Cambridge University Press
Print publication year: 2020

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  • The Endocannabinoids
  • Steven James, University of California, San Diego
  • Book: A Clinician's Guide to Cannabinoid Science
  • Online publication: 12 October 2020
  • Chapter DOI: https://doi.org/10.1017/9781108583336.004
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  • The Endocannabinoids
  • Steven James, University of California, San Diego
  • Book: A Clinician's Guide to Cannabinoid Science
  • Online publication: 12 October 2020
  • Chapter DOI: https://doi.org/10.1017/9781108583336.004
Available formats
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  • The Endocannabinoids
  • Steven James, University of California, San Diego
  • Book: A Clinician's Guide to Cannabinoid Science
  • Online publication: 12 October 2020
  • Chapter DOI: https://doi.org/10.1017/9781108583336.004
Available formats
×