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Carbapenem-resistant Acinetobacter baumannii (CRAB) carriage in post-acute care hospitals (PACH) reflects both importation of colonized patients and within-PACH transmission. We studied within-PACH transmission by examining the sameness of CRAB clusters, as identified by Fourier-transform infrared (FTIR) spectroscopy.
Methods:
We conducted a point-prevalence survey in 55 wards in 18 Israeli PACH in 2021. Patients (n = 1,733) were screened for CRAB, and 461 isolates from 357 patients underwent FTIR typing (IR Biotyper, Bruker). We assigned each patient isolate to its cluster and paired each patient-cluster combination with every other patient-cluster combination. We examined the relationship between physical proximity of pairs (n = 75,047) and FTIR cluster sameness using generalized estimating equation logistic regression. To estimate within-ward transmission, we compared proportions of cluster sameness within wards versus between institutions.
Results:
The 461 CRAB isolates formed 23 FTIR clusters. Compared to being in different institutions, being in the same ward was associated with significantly higher odds of sharing the same cluster (odds ratio: 3.6, p < 0.001). Odds ratios were highest for patients in the same room (6.2) or adjacent rooms (6.1) (p < 0.001 for both). Based on same-cluster pairs we estimated that 70% of prevalent CRAB cases resulted from within-ward transmission.
Conclusions:
CRAB strain similarity was strongly associated with spatial proximity within PACH wards, indicating that within-ward transmission is an important contributor to CRAB carriage prevalence. Similar risk in same and adjacent rooms suggests transmission via shared staff or equipment. Ward-level infection control interventions are warranted to interrupt spread.
Behavioral health needs are highly prevalent among individuals receiving long-term services and supports (LTSS), yet palliative care (PC) models in these settings often underemphasize psychiatric symptom management. This study explores interdisciplinary staff perspectives on behavioral health as a core domain of PC across nursing home and Program of All-Inclusive Care for the Elderly (PACE) sites.
Methods
We conducted a secondary analysis of a multi-site survey assessing PC needs across 13 LTSS sites within a large health system in New York State. We examined 5 survey items related to psychiatric symptom management, analyzing frequency, comfort, perceived benefit, and training interest. Multivariable logistic regression was used to assess associations between staff characteristics and behavioral health-related outcomes.
Results
Among 597 respondents, 60.5% reported that over half of their patients could benefit from psychiatric symptom management, and nearly half (49.2%) reported managing such symptoms weekly or more. Forty percent identified psychiatric symptom management as one of the top three ways PC specialists could help their patients, and 44.6% expressed interest in further behavioral health training as part of further PC training. Prior professional experience with PC was associated with greater recognition of behavioral health needs among patients (aOR 1.6), greater likelihood of managing psychiatric symptoms (aOR 2.0), and greater comfort doing so (aOR 1.5).
Significance of results
Behavioral health emerged as a salient and frequently encountered domain of serious illness care among LTSS staff, particularly in nursing home and PACE settings. Staff with prior PC experience were more engaged and confident in addressing psychiatric symptoms. Findings underscore the need for PC models in LTSS to better integrate behavioral health – through training, interdisciplinary collaboration, and care delivery redesign – to meet the complex needs of medically and psychiatrically vulnerable populations.
The Association of Otolaryngologists in Training wanted to assess trainee well-being.
Methods
A survey was developed that incorporated the Copenhagen Burnout Inventory, the short Warwick–Edinburgh Mental Wellbeing Scale and the Brief Resilience Scale plus questions on working conditions.
Results
There were 190 responses and while most respondents had low or moderate levels of burnout, 15 per cent had high personal burnout and 13 per cent had high work-related burnout. The mean well-being score for respondents was lower than for the whole population mean. In addition, 39 per cent of respondents reported their mental well-being had been slightly affected in a negative way by their working environment and conditions in the last 6 months, and 26 per cent reported it being significantly affected negatively. Of these, 43 respondents reported an impact on patient safety.
Conclusion
This first-ever survey of ENT trainees in the UK identified several areas of concern, including how the working environment and conditions affect trainee well-being and impact patient safety.
Button batteries are a common household item that are, unfortunately, attractive to young children. If ingested, they are corrosive and potentially fatal. Button battery ingestion is frequently unwitnessed, delaying the diagnosis. In the USA, approximately 6,000 accidental ingestions occur annually (2.2 deaths per year over a decade on average). Community awareness of this danger appears to be low.
Methods
We conducted a 22-question online questionnaire-based study to assess and raise awareness of this exceptional childhood risk.
Results
A total of 561 survey responses were analysed; 77 per cent were female, and 60 per cent were aged 30–50. Despite 87 per cent using button batteries, 65 per cent did not consider their safety, and 68 per cent found existing packaging warnings inadequate. Notably, 80 per cent recognised the potential for fatality, but 88 per cent were unaware that a spoonful of honey could delay this corrosive process.
Conclusion
Challenges persist regarding the design and marketing of button batteries and public awareness of their ingestion. Action is required to prevent further tragedies.
Adolescence is a critical period for brain maturation, influenced by stress and hormonal changes. Chronic stress can lead to increased allostatic load (AL), a cumulative measure of multisystem dysregulation, and insulin resistance (IR), both of which are linked to mental health disorders. We hypothesized that heightened AL and IR during adolescence (age 17) would predict the emergence of mood and psychotic symptoms in young adults.
Methods
This study used data from the Avon Longitudinal Study of Parents and Children, a population cohort from Bristol, United Kingdom.
Results
Our results showed that elevated AL at age 17 was significantly associated with the development of mood disorder symptoms (MDS) and psychotic disorder symptoms (PDS) and the co-occurrence of mood and psychotic disorder symptoms (MPDS) at age 24 (p < 0.001). Mean AL increased progressively across these symptom groups, indicating a dose–response relationship between physiological dysregulation and mental health burden (MDS = 3.67, PDS = 3.89, and MPDS = 4.03). We also observed that IR was significantly elevated in the MDS, PDS, and MPDS groups compared to healthy controls (HCs). IR was most prevalent in the PDS group, suggesting a possible association between metabolic dysfunction and psychosis risk.
Conclusion
This study demonstrated that multisystem dysregulation in late adolescence precedes the onset of mood and psychotic symptoms in early adulthood. These results support the use of AL and metabolic markers as early indicators of psychiatric vulnerability and highlight the potential for early intervention targeting systemic dysregulation to prevent the onset of mental health disorders.
Ultra-processed foods (UPF) are often energy dense and low in nutrients. High consumption of UPF has been associated with non-communicable diseases, premature mortality and environmental impacts. The objective of this study was to assess UPF consumption in relation to diet quality and associated greenhouse gas (GHG) emissions, previously not examined in Iceland. Data from the Icelandic National Dietary Survey (2019–2021, n 822) were utilised. The NOVA classification system was used classifying all food and drinks reported. Dietary GHG emissions were quantified using an open-source life cycle assessment database. On average, 45 %±15 of the total calories consumed daily were derived from UPF, ranging from 24 % in the lowest quartile (UPFQ1) to 64 % in the highest quartile (UPFQ4). The energy contribution of UPF considered to fall within the Icelandic dietary guidelines was 4 %±4. UPFQ4 had significantly lower consumption of, e.g. red meat, fruits, vegetables and whole grains and higher consumption of, e.g. refined grains, sweets and soft drinks, compared with UPFQ1. UPFQ4 had a significantly higher energy intake, added sugar intake and lower intake of, e.g. proteins and iodine. The median (interquartile range (IQR)) share of dietary GHG emissions was 21 % (IQR: 11–34) of total kg CO2-eq/d, while significantly lower in UPFQ4 compared with UPFQ1. Almost half of the daily energy intake of Icelandic diets was derived from UPF, reflecting relatively poor diet quality. However, dietary GHG emissions were relatively low in high consumers of UPF, reflecting higher meat consumption in low consumers of UPF. Findings underline the urgency of policy implementation, aligning food consumption with dietary guidelines.
Motor functional neurological disorder (FND) is a common illness associated with significant functional impairment. There are no effective pharmacotherapies, and despite the early promise of physiotherapy studies, many suffer disabling symptoms in the long term. There is a theoretical rationale for combining psychedelics with physiotherapy; however, the potential benefit of this approach and optimal treatment model remains unexplored. Here, we present the protocol for the first study investigating the tolerability, feasibility, and potential efficacy of two distinct treatment regimens of psilocybin-assisted physiotherapy for refractory motor FND: a moderate dose that incorporates movement tasks during the acute drug effects versus a standard dose alone.
Methods:
Twenty-four participants with refractory motor FND will be randomised in a 1:1 ratio to either (1) psilocybin 15 mg, with movement tasks conducted during the acute drug effects, or (2) psilocybin 25 mg alone. All participants will receive two sessions of FND-specific physiotherapy pre-dosing, six sessions of physiotherapy post-dosing, and undergo follow-up visits one week and four weeks following their final physiotherapy session. A battery of outcome measures will be completed as scheduled, assessing tolerability, feasibility, motor FND symptom severity, psychiatric and physical symptoms, quality of life, treatment expectations, intensity of the acute drug effects, personality, motor function, force-matching performance, resting-state and task-based brain imaging, and subjective experiences of the study treatment.
Discussion:
These findings will assist the design of an adequately powered randomised controlled trial in this cohort. The findings may also inform the feasibility of psychedelic treatment in related functional and neuropsychiatric disorders.
If excessive mistrust – for example, holding conspiracy beliefs or experiencing paranoia – is widespread then people should notice it in others. We aimed to assess the degree to which the general population had observed excessive mistrust. Paranoia is a particular form of excessive mistrust. How people understand paranoia, and therefore react to it, could affect its persistence. We also aimed to learn how the general population views paranoia.
Methods
A non-probability online survey was conducted in May 2024 with 1,036 UK adults, quota sampled to match the population for age, gender, ethnicity, income, and region. Nine examples of excessive mistrust in others were presented. Knowledge of paranoia was also assessed.
Results
Participants (n = 698, 67.4%) had most commonly encountered a person ‘Saying that they would not get a COVID-19 vaccination because of concerns about the real motivation behind the vaccine rollout’. Least commonly encountered by participants (n = 328, 31.7%) was a person ‘Thinking that others are targeting them in order to bully or exploit them, and so isolating from the world and refusing to leave their home’. A total of 854 (82.4%) participants had observed at least one form of excessive mistrust in the past year, most frequently in friends. More mistrustful participants were more likely to observe mistrustful behaviors. Participants endorsed multiple causes of paranoia, with the most endorsed causes being worry and illicit drugs.
Conclusions
The large majority of people have encountered others, primarily individuals they know, exhibiting excessive mistrust. Public understanding of paranoia varies greatly, with diverse definitions and perceived causes.
Course-prerequisite networks (CPNs) are directed acyclic graphs that model complex academic curricula by representing courses as nodes and dependencies between them as directed links. These networks are indispensable tools for visualizing, studying, and understanding curricula. For example, CPNs can be used to detect important courses, improve advising, guide curriculum design, analyze graduation time distributions, and quantify the strength of knowledge flow between different university departments. However, most CPN analyses to date have focused only on micro- and meso-scale properties. To fill this gap, we define and study three new global CPN measures: breadth, depth, and flux. All three measures are invariant under transitive reduction and are based on the concept of topological stratification, which generalizes topological ordering in directed acyclic graphs. These measures can be used for macro-scale comparison of different CPNs. We illustrate the new measures numerically by applying them to three real and synthetic CPNs from three universities: the Cyprus University of Technology, the California Institute of Technology, and Johns Hopkins University. The CPN data analyzed in this paper are publicly available in a GitHub repository.
Social cognition (SC) constitutes a predominant aspect of complex cognition (CC) especially in non-human animals. Apart from bees, ants and birds, fish, particularly the teleost group, are considered as an emerging model organism to study vertebrate SC. The commentary deals with some of the CC traits of SC across different families of teleost fish that have been experimentally reported.
We argue that cognitive evolution is rooted in the development of distributed functional internal models within hierarchical, decentralized, and multimodal sensorimotor loops. Based on an embodied cognition perspective, we emphasize how these models initially evolved to support adaptive behavior and can be flexibly recruited for higher cognitive functions. This perspective complements the proposed sensory-driven and vision-centric account.
While prematurely committing to a conception of “complex cognition” promises to stifle inquiry, tentatively specifying and empirically determining the relevant senses of “complex” could very well serve to drive the research program forward. This strategy has proven particularly useful in debates around simplicity. However, given that “complex” is a multi-dimensional adjective, all-things-considered comparative evaluations of it might not be possible.
The main goal of this paper is to introduce a new model of evolvement of beliefs on networks. It generalizes the DeGroot model and describes the iterative process of establishing the consensus in isolated social networks in the case of nonlinear aggregation functions. Our main tools come from mean theory and graph theory. The case, when the root set of the network (influencers, news agencies, etc.) is ergodic is fully discussed. The other possibility, when the root contains more than one component, is partially discussed and it could be a motivation for further research.
Social intelligences and goal-directed behaviors of mate selection show conservation throughout phylogeny, from unicellular to multicellular life. Some microbes co-evolved somatic ornaments and weapons, behavioral courtship and dominance routines, and decision-making logics that facilitate mate choice, rival deterrence, and monogamy, gating spread of inferior genes from promiscuous unions. Such “cognitive cell” adaptations help microbes direct niche evolution for improved survival.
Coombs and Trestman offer a cogent and biologically-grounded framework in which cognitive evolution is linked to the evolution of bodies and sensory-motor mechanisms. We are strongly supportive of such an endeavour, but argue that sensory-motor adaptations should rightly be seen as part and parcel of cognition itself and not simply as the foundation for cognitive evolution.
It is argued that there are huge differences between species of the “advanced” three phyla, both cognitively and neurally, and that more sophisticated attributes than vision and motion characterize only a few of them, and these are mainly found in vertebrates. Especially with respect to learning and memory, only some vertebrate species may possess sophisticated memory processing abilities.
The multilevel dimensions of sustainable diets associating food systems, public health, environmental sustainability, and culture are presented in this paper. It begins by defining sustainable diets as those that are healthful, have low environmental impacts, are affordable, and culturally acceptable. The discussion includes the history of research on sustainable diets, from initial studies focused on environmental impacts to more recent, comprehensive frameworks that integrate affordability, cultural relevance, and nutritional adequacy as key dimensions of diet sustainability. In addition, the paper highlights recent innovations, such as the Planetary Health Diet of EAT–Lancet and the SHARP model, and the conflicts and optimum trade-offs between sustainability and nutrition, particularly within low- and middle-income countries. Case descriptions of Mediterranean Diet with a focus on Traditional Lebanese Diet, and African Indigenous Foods demonstrate culturally confined dietary patterns associated with sustainability objectives. These examples show that sustainable diets are not a single set of prescriptions, but a series of multiple pathways that are shaped by local food environments, ecological belts, and sociocultural heritages. The paper also describes major policy and governance activities necessary to promote sustainable diets. Finally, the paper addresses measurement challenges and advocates for better indicator options to measure sustainable food systems in all their facets and for participatory and context-specific approaches. The discussion concludes that fairer and culturally diverse inclusion strategies, system change, and political determination are imperative in achieving sustainable diets. Diets able to sustain are posited as agents capable of driving the 2030 agenda, enhancing planetary health and social integrity.