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Phlebotomine sand flies are found across multiple regions of Thailand, with growing recognition of their role in transmitting zoonotic pathogens. Environmental factors, including climate variability and vector ecology, may influence their distribution and activity, contributing to the potential spread of zoonotic pathogens in Southeast Asia. However, comprehensive data on sand fly distribution in Thailand remain limited. To address this gap, a systematic review was conducted following PRISMA guidelines. Out of 112 records retrieved, 33 met the inclusion criteria and quality assessment for further analysis. As per results, sand flies are widespread in Thailand, with a high level of species diversity comprising 42 species of 6 different genera. However, several provinces lack data on the presence and distribution of sand flies. Eleven species were identified as the overall abundant species throughout the studies from January 2007 to June 2025 and grouped by abundance: low-abundance species (Sergentomyia barguesae, Sergentomyia phadangensis, Sergentomyia barraudi and Sergentomyia indica), abundant but understudied species (Sergentomyia sylvatica, Sergentomyia anodontis and Neopulpus vietnamensis) and most abundant species (Sergentomyia hodgsoni, Sergentomyia gemmea, Sergentomyia iyengari and Sergentomyia khawi). From the most abundant species, S. khawi tested positive for several pathogens, such as Leishmania spp., Trypanosoma spp., Bartonella spp. and orbivirus. Besides, S. khawi has been shown to exhibit human-biting behaviour through the analysis of blood meal. These findings raise concerns about its potential role in pathogen transmission, especially concerning zoonotic pathogens. However, vector competence remains unproven for some of these pathogens, suggesting the need for further research.
The target article identifies non-cognitive traits co-occurring with major transitions in complex cognition. We argue that observed trait associations are really the phenomenon to be explained, and propose that changes in the nervous system are the explanatory driver for transitional events. Changes in neural architecture uniquely enable organisms to utilise complex and specialised traits, and thus, explain their linked nature.
Liberia (West Africa) has an extensive (co)burden of urogenital and intestinal schistosomiasis; each largely restricted to more inland areas. Where urogenital schistosomiasis is endemic, as both disease surveillance and case management are nascent, many women may unknowingly be living with Female Genital Schistosomiasis (FGS). Using a recently developed FGS score card, we appraised FGS score card valuations with point-of-care gynaecological and molecular parasitological evaluations as undertaken within typical primary care settings of four Liberian counties. A total of 400 women, 100 participants from each of four endemic inland counties, underwent a cursory gynaecological examination using a speculum for visible FGS lesions, undertaken by a midwife, and provided a urine sample that was examined by centrifugation with microscopy for Schistosoma ova. Urine-sediments in ethanol were later analysed with a high-resolution melt (HRM) real-time (rt) PCR assay to screen for Schistosoma genetic markers. Using a combination of clinical and parasitological information, overall prevalence of UGS and FGS was <10% and a single case of putative FGS-associated co-infection with Schistosoma mansoni was observed. Participant interviews with the FGS score cards provided an insight into at-risk lifestyle and environmental factors, e.g. women who fished regularly were more likely to present with FGS whereas those who lived > 15 km from a local river were less likely to present with FGS. In this resource-poor setting of Liberia, active surveillance for FGS with either clinical or parasitological methods remains challenging such that sole future use of the FGS score card is most pragmatic for primary care.
Collating the neural traits possessed by taxa provides valuable evidence about brain evolution. However, to get the full scientific benefit, we must pair it with an understanding of the selection pressures driving brain complexity. This can be achieved by considering the heterogeneity of the animal’s environment alongside the reliability of information. A complex environment selects for a complex brain.
In canvassing the animal kingdom for cognitive capacity by a multitrait approach, much hinges on how traits are operationally defined. In my commentary, I call attention to problematic aspects of the perspective on learning, a central component of cognition, adopted by Coombs and Trestman in their phylogenetic survey of cognitive capacity.
According to the principles of the European Pillar of Social Rights, everyone should be entitled to an adequate minimum income sufficient for a healthy diet. Studies show that food insecurity remains a concern in Europe, highlighting the need to determine budgets for adequate nutrition, known as Food Reference Budgets. Previous approaches, based on expert-designed food baskets or focus group discussions, are often limited by their normative nature and/or low representativeness.
Design:
To address these problems, this study explores Linear Programming as a novel method to calculate Food Reference Budgets for twenty-six EU member states. To analyse if Linear Programming could be an adequate tool to calculate future Food Reference Budgets, this method was used to design country-specific food baskets that align with consumption habits and healthy diet requirements. The food baskets were then priced at different levels to determine the cost for healthy diets in twenty-six European countries.
Setting:
Germany.
Participants:
The calculations are based on consumption data from the EU Household Budget Survey (EU-HBS) from 2015 (2010 for Malta, Portugal and Slovenia). For Germany, data from the national income and consumption survey was used instead, as German data was not included in the EU-HBS.
Results:
The results show a positive correlation between optimised healthy and current observed diets for most food groups, indicating that country-specific preferences are reflected in the optimised healthy food baskets. Nevertheless, to meet healthy diet requirements, consumption of vegetables, fruit, fish and dairy must increase compared with the current observed diets. At a lower price level, the Food Reference Budgets ranged from 2·38 to 5·71 €/day, depending on the country. With a low-price level (20th percentile), costs for healthy diet accounted for between 5·74 % of income in Luxembourg and 29·00 % in Romania, showing the large differences in affordability between countries.
Conclusion:
Overall, it was concluded that Linear Programming could be a promising approach for determining uniform and comparable European Food Reference Budgets and should be discussed in the context of the EU Commission’s efforts to modernise the European minimum income schemes.
Despite the increasing implementation of consultation-based hospice palliative care teams in tertiary hospitals of Korea, there is limited research on their impact on self-determination respect rates. Understanding this impact is crucial for improving end-of-life care practices and respecting patient autonomy. The aim of this study is to assess the trends in self-determination respect rates regarding advance care planning before and after the introduction of a consultation-based hospice palliative care team in a tertiary hospital.
Methods
A retrospective observational study was conducted using medical records from a tertiary hospital in Korea from March 2018 to December 2023. The study included all patients aged 19 years and older with medical records at a tertiary hospital during the specified period. We examined the characteristics of patients referred to the palliative care team, the effects of the consultation-based hospice palliative care team on the completion rates of advanced care planning, and changes in self-determination respect rates.
Results
Following the introduction of the consultation-based hospice palliative care team, 411 patients were referred. The proportion of patients with completed advance care planning increased from 27.0% to 60.6% (p < 0.001). The overall number of advanced care planning completions and the self-determination respect rate also showed a marked increase, particularly from 2021 to 2022, when the respect rate spiked from 27.6% to 43.2%.
Significance of Results
Introduction of a consultation-based hospice palliative care team improved the respect for patient self-determination in end-of-life care decisions. These findings support the integration of hospice care teams in tertiary hospitals to enhance early and informed end-of-life decision-making.
Declining participant engagement threatens human subjects research. Participant feedback systems (PFS) may combat this decline by empowering participants to evaluate their research experiences and share that feedback with researchers to identify targets for improvement. PFS signal that participant experiences are prioritized, making the request for feedback itself an intervention. PFS design work remains largely confined to clinical research. This exploratory study investigates the design parameters of extending PFS to nonclinical research. We conducted focus groups with nonclinical stakeholders: Experienced research participants (ERP) and research team members (RTM).
Methods:
ERP focus groups were organized by affinity (LGBTQIA+, BIPOC, persons with disabilities, neurodivergent, and a general group). RTM focus groups were organized by unit within the University of Michigan. Transcripts were analyzed using inductive thematic analysis.
Results:
Ten focus groups (ERP: 5, n = 25; RTM: 5, n = 26) identified key PFS design considerations: (1) motivations for feedback, (2) feedback collection, and (3) feedback delivery. ERP and RTM collectively preferred anonymous web-based surveys with six potential topic areas: communication, respect, being valued, receiving value, burden, and safety. Feedback delivery faced two key design tensions: balancing institutional standardization with study-specific insights and aligning leadership’s preference for high-level summaries with frontline staff’s need for detailed, real-time feedback.
Conclusion:
Expanding PFS to nonclinical research requires balancing centralization and study-specific flexibility. While centralization enhances consistency, the diversity of nonclinical studies necessitates adaptable implementation. A hybrid model is proposed to optimize feasibility. Future research should refine and test this model.
The 2023 Gaza War has severely affected children’s health and development. This field-based synthesis draws from humanitarian agency reports and public health data to document impacts across physical health, nutrition, mental well-being, and education. Key findings include severe malnutrition, psychological trauma, and collapse of health care and education systems. Humanitarian access remains limited due to embedded military infrastructure and active conflict zones. Recommendations call for protected corridors, mobile health units, targeted mental health support, and stronger international accountability.
Inclusion of uninsured and underinsured (UUI) individuals in clinical research (CR) is necessary to ensure data quality, diversity, generalizability and fairness. Yet, in the USA, UUI persons tend to be excluded from CR. We conducted an ethical analysis of: the regulatory and ethics literature related to protections of, and duty to care for, research participants from vulnerable groups; the nature and scope of the ancillary health care obligations of researchers, and the applicable laws, regulations and practices concerning the care for UUI participants. We consider six examples illustrating the challenges of including UUI persons in CR. We note that addressing fully the challenges of UUI participation in CR requires comprehensive legal and health care reforms. We maintain that even in the absence of such reforms, researchers, study sponsors and Institutional Review Boards can and ought to adopt an inclusive approach to the recruitment of UUI individuals to improve data quality, diversity, generalizability and social justice. We propose such a systematic, proactive and ethically sound approach. It considers the medical and ancillary care needs of UUI participants, addresses them in the study protocol and budget, and includes referral to community health resources, follow-up support, and noting assistance in the research records.
A major driver of the link between poor water, sanitation and hygiene (WASH) and child stunting is hypothesised to be a sub-clinical condition of the small intestine termed environmental enteric dysfunction (EED). This systematic review aimed to collate research investigating the association between biomarkers of EED and child linear growth outcomes. A systematic search of literature was conducted to identify articles that contain a measure of a domain of EED and its association with linear growth outcomes published up to 31 December 2024. Data pertaining to the measure of EED and child linear growth, as well as study characteristics, were extracted and tabulated. A total of eighty-one studies comprising 31 996 children were included, which suggested that all EED domains, including intestinal damage and repair, intestinal absorption and permeability, microbial translocation, intestinal inflammation and systemic inflammation, were associated with child linear growth. Nuances in the measurement of association were apparent and impacted the observation of significant associations. This review found that whilst the role of EED in child stunting is relatively well established, there are challenges faced in measuring biomarkers in relation to linear growth with possible ambiguities. These issues are discussed in detail to provide aid in interpretation of existing studies and to inform future studies of this kind.
The Mediterranean Diet (Med Diet) has long been shown to be associated with lower cardiovascular mortality in epidemiological studies. However, the direct effect of the dietary pattern on cardiovascular risk factors is less clear. Furthermore, the effect of Med Diet interventions in non-Mediterranean populations on cardiovascular and metabolic risk is variable. A Cochrane Review in 2019 concluded there was low to moderate evidence of a modest benefit but noted that there were still ongoing trials. Since 2019, there have been a number of published trials that have not shown a benefit of the Med Diet over other interventions or usual care. It is possible that dietary factors such as quality or quantity of carbohydrate and energy restriction are more important factors, along with the degree of weight loss, than the Med Diet itself. There are also many other factors that influence the uptake and effectiveness of the Med Diet in populations that have a different traditional or habitual diet. This review paper examines a selection of 20 Med Diet intervention trials specifically looking at clinical outcomes of glucose metabolism: fasting plasma glucose, HbA1c, development of type 2 diabetes or need for hypoglycaemic medications, with or without other cardiometabolic risk factors. These trials are a mix of randomised controlled trials, crossover studies and cohort studies of greater than 8 weeks duration with more than 25 participants. There is heterogeneity in study designs and outcomes, making comparison difficult, but there is no clear benefit of the Med Diet presented.
This commentary integrates Coombs and Trestman’s trait-linkage hypothesis with Teufel and Fletcher’s neurocomputational predictive framework to propose that high-resolution visual systems operate as intrinsic bottom-up predictive mechanisms. By merging these concepts, we emphasize the significance of early sensory prediction in perception and provide a biologically inspired foundation for developing more adaptive, embodied, and cognitively resilient artificial intelligence (AI) systems.
Coombs and Trestman propose to leverage what we know about the evolution of bodies to help explain the evolution of advanced cognition. While their “pivotal” traits are intended to ground the “future evolvability of complex cognition,” it’s not clear how we are supposed to get from here to there. I identify key theoretical challenges to building this bridge.
National Healthcare Safety Network developed a hospital-onset bacteremia (HOB) reporting module which may be used for Centers for Medicare and Medicaid Services (CMS)-reimbursement in the future. This retrospective study compared CMS-reported, HOB, and Overlap events. There were twice as many HOB as CMS events, but >40% of HOB were due to infections that lack defined infection prevention practices.
As natural disasters become more frequent and severe, healthcare organizations are tasked with ensuring both operational continuity and workforce wellbeing. This study examines the preparedness, response, and recovery efforts of a nationally ranked children’s hospital in the southeastern United States during the 2024 hurricane season, focusing specifically on the experiences of advanced psychology trainees.
Methods
Doctoral and postdoctoral trainees (N = 9) completed a brief anonymous survey examining departmental and organizational hurricane preparedness strategies and response following two successive hurricanes.
Results
Results revealed variable engagement of trainees with preparedness materials and increased distress with threat of the second storm. Communication from training directors was identified as a key support factor, with trainees preferring personalized updates over broader organizational messaging. While most trainees reported their long-term career decisions are unlikely to be impacted by their hurricane experiences, one-third noted that geographic risk may influence future professional choices.
Conclusions
Findings highlight the importance of integrating disaster preparedness into training programs and underscore the need for tailored supports to promote psychological resilience during times of uncertainty. Limitations and recommendations for future multi-site, multi-informant, mixed-methods research are discussed to inform best practices in disaster preparedness for healthcare trainees.
To examine awareness of metabolic syndrome, lifestyle habits and attitudes towards physical health monitoring in a cohort of service users prescribed clozapine.
Methods:
A cross-sectional study, utilising chart reviews and surveys, of service users attending a clozapine clinic in Ireland, to examine awareness of metabolic syndrome, current dietary and exercise habits and attitudes towards physical health checks for metabolic syndrome was conducted.
Results:
Sixty-nine service users attending the clozapine clinic (53.1% of attendees) participated in the study of which 23 (33.3%) participants met criteria for metabolic syndrome within the previous 12 months. Nine (13.0%) participants were aware of the term “metabolic syndrome”, with six aware of what metabolic syndrome entailed. Forty-seven (68.1%) participants described their diet as “healthy”, with 17 (24.6%) participants reporting the consumption of five portions of fruit and vegetables per day on a regular basis. Thirty-eight (55.1%) participants reported engaging in ≥ 2.5 hours of exercise per week. Most participants (> 70% for all physical indices) agreed that physical health monitoring was important with 46 participants (66.7%) stating physical health monitoring should occur monthly.
Conclusion:
Although there was a limited awareness and understanding of “metabolic syndrome” in this cohort of service users prescribed clozapine, monitoring of physical health indices was acknowledged as important. Early dietary and exercise interventions in an attempt to combat high morbidity and premature mortality rates are advised for this service user cohort.
Structural abnormalities in cortical and subcortical brain regions are consistently observed in schizophrenia; however, substantial inter-individual variability complicates identifying clear neurobiological biomarkers. The Person-Based Similarity Index (PBSI) quantifies individual structural variability; however, its applicability across schizophrenia stages remains unclear. This study aimed to compare cortical and subcortical structural variability in recent-onset and chronic schizophrenia and explore associations with clinical measures.
Methods:
Neuroimaging data from 41 patients with recent-onset schizophrenia, 32 with chronic schizophrenia, and 59 healthy controls were analysed. The PBSI scores were calculated for cortical thickness, surface area, cortical grey matter volume, and subcortical volumes. Group differences in PBSI scores were assessed using linear regression and analysis of variance. Correlations between the PBSI scores and clinical measures were also examined.
Results:
Both patients with recent-onset and chronic schizophrenia exhibited significantly lower PBSI scores than healthy controls, indicating greater morphometric heterogeneity. However, significant differences between the recent-onset and chronic patient groups were limited to subcortical and cortical thickness PBSI scores. Correlations between PBSI scores and clinical symptoms are sparse and primarily restricted to surface area variability and symptom severity in patients with recent-onset schizophrenia.
Conclusion:
Patients with schizophrenia show marked structural brain heterogeneity compared with healthy controls, which is detectable even in the early stages of the illness. Although there were few differences in PBSI scores between the recent-onset and chronic schizophrenia groups and limited correlations between PBSI scores and clinical measures, the PBSI may still provide valuable insights into individual differences contributing to clinical heterogeneity in schizophrenia.
Through a range of coping strategies, individuals seek to manage the stressors to which they are exposed, employing cognitive and behavioral responses that shape their emotional regulation of such events. Emergency first responders are routinely subjected to high-stress situations due to the nature of their duties and the continuous care of critically ill patients. This sustained exposure significantly increases their vulnerability to the development of mental health disorders, notably posttraumatic stress disorder (PTSD).
Objective:
The aim of this study was to determine the coping strategies used by first responders when facing critical incidents and their association with PTSD.
Methods:
A cross-sectional analytical study was conducted in 2022. All first responders from a volunteer fire department in a major Colombian city who voluntarily agreed to participate were included in the study. The participants were 28 ambulance crew members and 187 firefighters. Descriptive statistics were used for data analysis, and logistic regression models were applied to assess associations with PTSD. Principal components analysis was used to compute total scores, while the Lasso Method identified significant predictors.
Results:
The first responders most often employed avoidance and denial as coping strategies in response to the demands of their work in the prehospital field. After witnessing devastating events, many of them turned to religion for stress relief.
Conclusions:
The study identified the use of maladaptive strategies associated with PTSD among staff, making it critical to develop training programs that help first responders cope with critical incidents by developing adaptive coping skills.
This target article provides a valuable biological basis for life-mind continuity approaches. These explain cognition in the context of the origin and evolution of life itself. We argue that the features which are critical to sophisticated human cognition in late phylogenetic development are already present in the traits highlighted in the target article as pivotal for the development of cognitive complexity.