To probe the changing roles and responsibilities of intellectuals, this article explores the world of Ali Mazrui, one of Africa’s best-known scholars. Mazrui’s lifelong work spans the entire postcolonial period, and offers a prism for viewing African studies. Methodologically, this intellectual ethnography stages dialogues between Mazrui and other leading thinkers who have examined the nexus of knowledge and power. More specifically, Mazrui engages in controversies on complex issues such as Afrocentrism, religiosity, gender, and youth. Debates with his critics address fundamental questions facing Africa: grappling with social transformation, expanding policy space, and building ladders of development.