Hostname: page-component-7dd5485656-s6l46 Total loading time: 0 Render date: 2025-10-31T15:50:34.964Z Has data issue: false hasContentIssue false
  • English
  • Français

Bodily arousal differentially impacts stimulus processing and memory: Norepinephrine in interoception

Published online by Cambridge University Press:  05 January 2017

Hugo D. Critchley  and
Sarah N. Garfinkel
Hugo D. Critchley
Affiliation:
Sackler Centre for Consciousness Science, University of Sussex, Brighton, East Sussex BN1 9RH, United Kingdom www.sussex.ac.uk/sackler/ Psychiatry, Department of Neuroscience, Brighton and Sussex Medical School, Brighton, East Sussex BN1 9PX, United Kingdom h.critchley@bsms.ac.uk s.garfinkel@bsms.ac.uk www.bsms.ac.uk/research/our-research/psychiatry Sussex Partnership NHS Foundation Trust, Swandean Worthing, West Sussex BN13 3EP, United Kingdom
Sarah N. Garfinkel
Affiliation:
Sackler Centre for Consciousness Science, University of Sussex, Brighton, East Sussex BN1 9RH, United Kingdom www.sussex.ac.uk/sackler/ Psychiatry, Department of Neuroscience, Brighton and Sussex Medical School, Brighton, East Sussex BN1 9PX, United Kingdom h.critchley@bsms.ac.uk s.garfinkel@bsms.ac.uk www.bsms.ac.uk/research/our-research/psychiatry
Get access Rights & Permissions [Opens in a new window]

Abstract

Bodily arousal modulates stimulus processing and memory, contributing to expression of emotional salience. The “glutamate amplifies noradrenergic effects” (GANE) model proposed by Mather and colleagues can be extended to account for the differential impact of interoceptive (notably cardiac afferent) signals on sensory processing. However, some emotion-specific effects, for example, for fear, may further depend on functional anatomical organisation of affect-related brain structures.

Information

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 39 , 2016 , e205
Copyright
Copyright © Cambridge University Press 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Anderson, A. K. & Phelps, E. A. (2001) Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature 411:305–309.Google Scholar
De Martino, B., Strange, B. A. & Dolan, R. J. (2008) Noradrenergic neuromodulation of human attention for emotional and neutral stimuli. Psychopharmacology (Berlin) 197:127–36.Google Scholar
Elam, M., Thorén, P. & Svensson, T. H. (1986) Locus coeruleus neurons and sympathetic nerves: Activation by visceral afferents. Brain Research 375(1):117–25.Google Scholar
Elam, M., Yoa, T., Svensson, T. & Thoren, P. (1984) Regulation of locus coeruleus neurons and splanchnic, sympathetic nerves by cardiovascular afferents. Brain Research 290(2):281–87.Google Scholar
Garfinkel, S. N., Barrett, A. B., Minati, L., Dolan, R. J., Seth, A. K. & Critchley, H. D. (2013). What the heart forgets: Cardiac timing influences memory for words and is modulated by metacognition and interoceptive sensitivity. Psychophysiology 50(6):505–12. doi: 10.1111/psyp.12039.CrossRefGoogle ScholarPubMed
Garfinkel, S. N., Minati, L., Gray, M. A., Seth, A. K., Dolan, R. J. & Critchley, H. D. (2014) Fear from the heart: Sensitivity to fear stimuli depends on individual heartbeats. The Journal of Neuroscience 34(19):6573–82.Google Scholar
Gray, M. A., Rylander, K., Harrison, N. A., Wallin, B. G. & Critchley. H. D. (2009) Following one's heart: Cardiac rhythms gate central initiation of sympathetic reflexes. The Journal of Neuroscience 29:1817–25.Google Scholar
Hassert, D. L., Miyashita, T. & Williams, C. L. (2004) The effects of peripheral vagal nerve stimulation at a memory-modulating intensity on norepinephrine output in the basolateral amygdala. Behavioral Neuroscience 118:79–88.Google Scholar
Lambertz, M. & Langhorst, P. (1995) Cardiac rhythmic patterns in neuronal activity are related to the firing rate of the neurons: I. Brainstem reticular neurons of dogs. Journal of the Autonomic Nervous System 51:153–63.Google Scholar
Lambertz, M., Schulz, G. & Langhorst, P. (1995) Cardiac rhythmic patterns in neuronal activity related to the firing rate of the neurons: II. Amygdala neurons of cats. Journal of the Autonomic Nervous System 51:165–73.Google Scholar
Morilak, D. A., Fornal, C. & Jacobs, B. L. (1986) Single unit activity of noradrenergic neurons in locus coeruleus and serotonergic neurons in the nucleus raphe dorsalis of freely moving cats in relation to the cardiac cycle. Brain Research 399(2):262–70.Google Scholar
Murase, S., Inui, K. & Nosaka, S. (1994) Baroreceptor inhibition of the locus coeruleus noradrenergic neurons Neuroscience 61:635–43.Google Scholar
Park, H. D., Correia, S., Ducorps, A. & Tallon-Baudry, C. (2014) Spontaneous fluctuations in neural responses to heartbeats predict visual detection. Nature Neuroscience 17:612–18.CrossRefGoogle ScholarPubMed
Svensson, T. H. (1987) Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: Putative implications for psychiatry and psychopharmacology. Psychopharmacology (Berl) 92:1–7.CrossRefGoogle ScholarPubMed