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Memory reconsolidation, emotional arousal, and the process of change in psychotherapy: New insights from brain science

  • Richard D. Lane (a1), Lee Ryan (a2), Lynn Nadel (a3) and Leslie Greenberg (a4)


Since Freud, clinicians have understood that disturbing memories contribute to psychopathology and that new emotional experiences contribute to therapeutic change. Yet, controversy remains about what is truly essential to bring about psychotherapeutic change. Mounting evidence from empirical studies suggests that emotional arousal is a key ingredient in therapeutic change in many modalities. In addition, memory seems to play an important role but there is a lack of consensus on the role of understanding what happened in the past in bringing about therapeutic change. The core idea of this paper is that therapeutic change in a variety of modalities, including behavioral therapy, cognitive-behavioral therapy, emotion-focused therapy, and psychodynamic psychotherapy, results from the updating of prior emotional memories through a process of reconsolidation that incorporates new emotional experiences. We present an integrated memory model with three interactive components – autobiographical (event) memories, semantic structures, and emotional responses – supported by emerging evidence from cognitive neuroscience on implicit and explicit emotion, implicit and explicit memory, emotion-memory interactions, memory reconsolidation, and the relationship between autobiographical and semantic memory. We propose that the essential ingredients of therapeutic change include: (1) reactivating old memories; (2) engaging in new emotional experiences that are incorporated into these reactivated memories via the process of reconsolidation; and (3) reinforcing the integrated memory structure by practicing a new way of behaving and experiencing the world in a variety of contexts. The implications of this new, neurobiologically grounded synthesis for research, clinical practice, and teaching are discussed.



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Abbass, A. (2002) Office based research in ISTDP: Data from the first 6 years of practice. Ad Hoc Bulletin of Short-term Dynamic Psychotherapy 6:514.
Abelson, J. L., Khan, S., Young, E. A. & Liberzon, I. (2010) Cognitive modulation of endocrine responses to CRH stimulation in healthy subjects. Psychoneuroendocrinology 35:451–59.
Aggleton, J. P. & Brown, M. W. (1999) Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behavioral and Brain Sciences 22:425–89.
Alexander, F. & French, T. M. (1946) The corrective emotional experience. In: Psychoanalytic therapy: Principles and application. Ronald.
Allen, J. G. (2013) Mentalizing in the development and treatment of attachment trauma. Karnac.
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, fifth edition. American Psychiatric Association.
Amodio, D. M. & Frith, C. D. (2006) Meeting of minds: The medial frontal cortex and social cognition. Nature Reviews Neuroscience 7:268–77.
Auszra, L., Greenberg, L. & Herrmann, I. (2013) Client emotional productivity – optimal client in-session emotional processing in experiential therapy. Psychotherapy Research 23(6):732–46.
Barrett, L. F., Mesquita, B., Ochsner, K. N. & Gross, J. J. (2007) The experience of emotion. Annual Review of Psychology 58:373403.
Barsalou, L. W. (1988) The content and organization of autobiographical memories. In: Remembering reconsidered: Ecological and traditional approaches to the study of memory, ed. Neisser, U. & Winograd, E., pp. 193243. Cambridge University Press.
Bartlett, F. C. (1932) Remembering: A study in experimental and social psychology. Cambridge University Press.
Beck, A. T. (1979) Cognitive therapy and the emotional disorders. International Universities Press.
Beck, A. T., Rush, A. J., Shaw, B. E. & Emery, G. (1979) Cognitive therapy of depression. Guilford Press.
Bergman, E. T. & Roediger, H. L. III (1999) Can Bartlett's repeated reproduction experiments be replicated? Memory and Cognition 27:937–47.
Berntsen, D. & Rubin, D. C. (2006) The Centrality of Event Scale: A measure of integrating a trauma into one's identity and its relation to post-traumatic stress disorder symptoms. Behaviour Research and Therapy 44(2):219–31.
Berntsen, D. & Thomsen, D. K. (2005) Personal memories for remote historical events: Accuracy and clarity of flashbulb memories related to World War II. Journal of Experimental Psychology: General 134:242–57.
Bootzin, R. R. & Epstein, D. R. (2011) Understanding and treating insomnia. Annual Review of Clinical Psychology 7:435–58.
Borkovec, T. D. & Sides, J. K. (1979) Critical procedural variables related to the physiological effects of progressive relaxation: A review. Behaviour Research and Therapy 17:119–25.
Bornstein, R. F. (2001) The impending death of psychoanalysis. Psychoanalytic Psychology 18(1):320.
Brenner, C. (1973) An elementary textbook of psychoanalysis. International Universities Press.
Breuer, J. & Freud, S. (1895/1955) Studies on hysteria. In: Standard edition of the complete psychological works of Sigmund Freud, ed. Strachey, J.. Hogarth Press. (Original work published in 1895.)
Brunet, A., Orr, S. P., Tremblay, J., Robertson, K., Nader, K. & Pitman, R. K. (2008) Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. Journal of Psychiatric Research 42:503–6.
Burke, A., Heuer, F. & Reisberg, D. (1992) Remembering emotional events. Memory and Cognition 20:277–90.
Bushman, B. J. (2002) Does venting anger feed or extinguish the flame? Catharsis, rumination, distraction, anger and aggressive responding. Personality and Social Psychology Bulletin 28:724–31.
Butler, A. C., Chapman, J. E., Forman, E. M. & Beck, A. T. (2006) The empirical status of cognitive-behavioral therapy: A review of meta-analyses. Clinical Psychology Review 26:1731.
Cahill, L. (2000) Neurobiological mechanisms of emotionally influenced, long-term memory. Progress in Brain Research 126:2937. Available at:
Campbell, J., Nadel, L., Duke, D. & Ryan, L. (2011) Remembering all that and then some: Recollection of autobiographical memories after a 1-year delay. Memory 19:406–15.
Carryer, J. & Greenberg, L. (2010) Optimal levels of emotional arousal in experiential therapy of depression. Journal of Consulting and Clinical Psychology 78:190–99.
Castonguay, L. G., Goldfried, M. R., Wiser, S., Raue, P. J. & Hayes, A. M. (1996) Predicting the effect of cognitive therapy for depression: A study of unique and common factors. Journal of Consulting and Clinical Psychology 64:497504.
Christianson, S. (1992) Emotional stress and eyewitness memory: A critical review. Psychological Bulletin 112:284309.
Christianson, S. & Loftus, E. (1991) Remembering emotional events: The fate of detailed information. Cognition and Emotion 5:81108.
Clore, G. L. & Ortony, A. (2000) Cognition in emotion: Always, sometimes or never? In: Cognitive neuroscience of emotion, ed. Lane, R. & Nadel, L., pp. 2461. Oxford University Press.
Clyman, R. B. (1991) The procedural organization of emotions: A contribution from cognitive science to the psychoanalytic theory of therapeutic action. Journal of the American Psychoanalytic Association 39:349–82.
Cohen, G., Conway, M. A. & Maylor, E. A. (1994) Flashbulb memories in older adults. Psychology and Aging 9:454–63.
Coluccia, E., Bianco, C. & Brandimonte, M. A. (2006) Dissociating veridicality, consistency, and confidence in autobiographical and event memories for the Columbia shuttle disaster. Memory 14:452–70.
Coombs, M. M., Coleman, D. & Jones, E. E. (2002) Working with feelings: The importance of emotion in both cognitive-behavioral and interpersonal therapy in the NIMH treatment of depression collaborative research program. Psychotherapy Theory, Research, Practice, Training 39:233–44.
Darwin, C. (1872) The expression of the emotions in man and animals. John Murray.
Davidson, P., Cook, S. P. & Glisky, E. L. (2006) Flashbulb memories for September 11th can be preserved in older adults. Aging, Neuropsychology, and Cognition: A Journal on Normal and Dysfunctional Development 13:196206.
De Boer, S. F. & Koolhaas, J. M. (2003) Defensive burying in rodents: Ethology, neurobiology and psychopharmacology. European Journal of Pharmacology 463:145–61.
de la Fuente, V., Freudenthal, R. & Romano, A. (2011) Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval. Journal of Neuroscience 31:5562–73.
de Quervain, D. J., Henke, K., Aerni, A., Treyer, V., McGaugh, J. L., Berthold, T., Nitsch, R. M., Buck, A., Roozendaal, B. & Hock, C. (2003) Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe. The European Journal of Neuroscience 17:1296–302.
de Quervain, D. J., Roozendaal, B., Nitsch, R. M., McGaugh, J. L. & Hock, C. (2000) Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nature Neuroscience 3:313–4.
Debiec, J. & Ledoux, J. E. (2004) Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Neuroscience 129:267–72.
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J. & Zoladz, P. R. (2007) The temporal dynamics model of emotional memory processing: A synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson law. Neural Plasticity 2007:133.
Diekelmann, S., Wilhelm, I. & Born, J. (2009) The whats and whens of sleep-dependent memory consolidation. Sleep Medicine Reviews 13:309–21.
Dobson, K. S. (2009) Handbook of cognitive-behavioral therapies, third edition. Guilford.
Dudai, Y. (2004) The neurobiology of consolidation, or, how stable is the engram? Annual Review of Psychology 55:5186.
Ecker, B., Ticic, R. & Hulley, L. (2012) Unlocking the emotional brain: Eliminating symptoms at their roots using memory reconsolidation. Routledge.
Edelman, G. M. (1989) The remembered present: A biological theory of consciousness. Basic Books.
Eich, E., Macaulay, D. & Ryan, L. (1994) Mood dependent memory for events of the personal past. Journal of Experimental Psychology: General 123:201–15.
Ellis, A. (1962) Reason and emotion in psychotherapy. Lyle Stuart.
Erdelyi, M. H. (2006) The unified theory of repression. Behavioral and Brain Sciences 29(5):499510.
Esterson, A. (2002) The myth of Freud's ostracism by the medical community in 1896–1905: Jeffrey Masson's assault on truth. History of Psychology 5(2):115–34.
Eysenck, H. J. (1960) Behaviour therapy and the neuroses. Pergamon.
Foa, E. B. (2009) Effective treatments for PTSD: Practice guidelines from the international society for traumatic stress studies. Guilford.
Foa, E. B. & Kozak, M. J. (1986) Emotional processing of fear: Exposure to corrective information. Psychological Bulletin 99:2035.
Foa, E. B. & Kozak, M. J. (1998) Clinical applications of bio-informational theory: Understanding anxiety and its treatment. Behavior Therapy 29:675–90.
Foa, E. B., Riggs, D. S., Massie, E. D. & Yarczower, M. (1995) The impact of fear activation and anger on the efficacy of exposure treatment for posttraumatic stress disorder. Behavior Therapy 26:487–99.
Foa, E. B., Rothbaum, B. O. & Furr, J. M. (2003) Augmenting exposure therapy with other CBT procedures. Psychiatric Annals 33:4753.
Foa, E. B., Steketee, G. & Rothbaum, B. O. (1989) Behavioral/cognitive conceptualizations of post-traumatic stress disorder. Behavior Therapy 20:155–76.
Fosha, D. (2000) The transforming power of affect: A model for accelerated change. Basic Books.
Frank, J. D. (1974a) Persuasion and healing: A comparative study of psychotherapy. Schocken Books.
Frank, J. D. (1974b) Psychotherapy: The restoration of morale. American Journal of Psychiatry 131:271–4.
Freud, S. (1913/1958) Papers on technique: On beginning the treatment (Further recommendations on the technique of psycho-analysis, I). In: The standard edition of the complete psychological works of Sigmund Freud, ed. Strachey, J.. Hogarth. (Original work published in 1913.)
Freud, S. (1914/1958) Papers on technique: Remembering, repeating, and working-through (Further recommendations on the technique of psycho-analysis, II). In: The standard edition of the complete psychological works of Sigmund Freud, ed. Strachey, J.. Hogarth. (Original work published in 1914.)
Freud, S. (1923/1961) The ego and the id. In: The standard edition of the complete psychological works of Sigmund Freud, ed. Strachey, J., pp. 166. Hogarth Press. (Original work published in 1923.)
Frijda, N. H. (1986) The emotions. Cambridge University Press.
Friston, K. (2010) The free-energy principle: A unified brain theory? Nature Reviews Neuroscience 11:127–38.
Frith, C. D. & Frith, U. (2012) Mechanisms of social cognition. Annual Review of Psychology 63:287313.
Gazzaniga, M. (1998) The mind's past. University of California Press.
Gergely, G. & Watson, J. S. (1996) The social biofeedback theory of parental affect-monitoring: The development of emotional self-awareness and self-control in infancy. The International Journal of Psychoanalysis 77(6):1181–212.
Gilboa-Schechtman, E. & Foa, E. B. (2001) Patterns of recovery from trauma: The use of intraindividual analysis. Journal of Abnormal Psychology 110:392400.
Gleaves, D. H. & Hernandez, E. (1999) Recent reformulations of Freud's development and abandonment of his seduction theory: Historical/scientific clarification or a continued assault on truth? History of Psychology 2(4):324–54.
Goldberger, M. (1995) The couch as defense and as potential for enactment. The Psychoanalytic Quarterly 64:2342.
Goldman, R. N., Greenberg, L. S. & Pos, A. E. (2005) Depth of emotional experience and outcome. Psychotherapy Research 15:238–49.
Graf, P. & Schacter, D. L. (1985) Implicit and explicit memory for new associations in normal and amnesic subjects. Journal of Experimental Psychology: Learning, Memory, and Cognition 11:501–18.
Greenberg, L. S. (2002) Emotion-focused therapy: Coaching clients to work through their feelings. APA Press.
Greenberg, L. S. (2010) Emotion-focused therapy: Theory and practice. APA Press.
Greenberg, L. S. & Pascual-Leone, A. (2006) Emotion in psychotherapy: A practice-friendly research review. Journal of Clinical Psychology: In Session 62:611–30.
Hardt, O., Einarsson, E. O. & Nader, K. (2010) A bridge over troubled water: Reconsolidation as a link between cognitive and neuroscientific memory research traditions. Annual Review of Psychology 61:141–67.
Heider, K. G. (1988) The Rashomon effect: When ethnographers disagree. American Anthropologist 90:7381.
Hirst, W., Phelps, E. A., Buckner, R. L., Budson, A. E., Cuc, A., Gabrieli, J. D., Johnson, M. K., Lustig, C., Lyle, K. B., Mather, M., Meksin, R., Mitchell, K. J, Ochsner, K. N., Schacter, D. L., Simons, J. S. & Vaidya, C. J. (2009) Long-term memory for the terrorist attack of September 11: Flashbulb memories, event memories, and the factors that influence their retention. Journal of Experimental Psychology: General 138(2):161.
Hofmann, S. G., Asmundson, G. J. G. & Beck, A. T. (2013) The science of cognitive therapy. Behavior Therapy 44:199212.
Horvath, A. O. & Luborsky, L (1993) The role of the therapeutic alliance in psychotherapy. Journal of Consulting and Clinical Psychology 61(4):561–73.
Hoscheidt, S., Dongaonkar, B., Payne, J. & Nadel, L. (2013) Emotion, stress, and memory. In: Oxford handbook of cognitive psychology, ed. Reisberg, D., pp. 557–70. Oxford University Press.
Hupbach, A., Gomez, R., Hardt, O. & Nadel, L. (2007) Reconsolidation of episodic memories: A subtle reminder triggers integration of new information. Learning and Memory 14(1–2):4753. Available at:
Hupbach, A., Hardt, O., Gomez, R. & Nadel, L. (2008) The dynamics of memory: Context-dependent updating. Learning and Memory 15(8):574–79. Available at:
Inda, M. C., Muravieva, E. V. & Alberini, C. M. (2011) Memory retrieval and the passage of time: From reconsolidation and strengthening to extinction. Journal of Neuroscience 31:1635–43.
Jaycox, L. H., Foa, E. B. & Morral, A. R. (1998) Influence of emotional engagement and habituation on exposure therapy for PTSD. Journal of Consulting and Clinical Psychology 66:185–92.
Jones, E. E. & Pulos, S. M. (1993) Comparing the process in psychodynamic and cognitive-behavioral therapies. Journal of Consulting and Clinical Psychology 61:306–16.
Kazdin, A. (2006) Mediators and mechanisms of change in psychotherapy research. Annual Review of Clinical Psychology 3:127.
Keysers, C. & Gazzola, V. (2006) Towards a unifying neural theory of social cognition. Progress in Brain Research 156:379401.
Kihlstrom, J. F., Mulvaney, S., Tobias, B. A. & Tobis, I. P. (2000) The emotional unconscious. In: Cognition and emotion, ed. Eich, E., Kihlstrom, J. F., Bower, G. H., Forgas, J. P. & Niedenthal, P. M., pp. 3086. Oxford University Press.
Kim, J. J. & Diamond, D. M. (2002) The stressed hippocampus, synaptic plasticity and lost memories. Nature Reviews Neuroscience 3:453–62.
Klein, M. H., Mathieu-Coughlan, P. & Kiesler, D. J. (1986) The Experiencing Scale. In: The psychotherapeutic process: A research handbook, ed. Greenberg, L. S. & Pinsof, M., pp. 2171. Guilford Press.
Klein, S. B., Cosmides, L., Tooby, J. & Chance, S. (2002) Decisions and the evolution of memory: Multiple systems, multiple functions. Psychological Review 2:306–29.
Kolber, A. J. (2006) Therapeutic forgetting: The legal and ethical implications of memory dampening. Vanderbilt Law Review 59:1561–626.
Kozak, M. J., Foa, E. B. & Steketee, G. (1988) Process and outcome of exposure treatment with obsessive-compulsives: Psychophysiological indicators of emotional processing. Behavior Therapy 19:157–69.
Kramer, R. (1995) The birth of client-centered therapy. Journal of Humanistic Psychology 35:54110.
Kuhlmann, S., Kirschbaum, C. & Wolf, O. T. (2005a) Effects of oral cortisol treatment in healthy young women on memory retrieval of negative and neutral words. Neurobiology of Learning and Memory 83:158–62.
Kuhlmann, S., Piel, M. & Wolf, O. T. (2005b) Impaired memory retrieval after psychosocial stress in healthy young men. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25:2977–82.
Labar, K. S. & Cabeza, R. (2006) Cognitive neuroscience of emotional memory. Nature Reviews Neuroscience 7:5464.
Lambert, M. J., Bergin, A. E. & Garfield, S. L. (2004) Introduction and historical overview. In: Bergin and Garfield's handbook of psychotherapy and behavior change, ed. Lambert, M. J., pp. 315. Wiley.
Lambie, J. A. & Marcel, A. J. (2002) Consciousness and the varieties of emotion experience: A theoretical framework. Psychological Review 109(2):219–59.
Landauer, T. K. & Dumais, S. T. (1997) A solution to Plato's problem: The latent semantic analysis theory of acquisition, induction, and representation of knowledge. Psychological Review 104:211–40.
Lane, R. (2000) Neural correlates of conscious emotional experience In: Cognitive neuroscience of emotion, ed. Lane, R., Nadel, L., pp. 345–70. Oxford University Press.
Lane, R. D. (2008) Neural substrates of implicit and explicit emotional processes: A unifying framework for psychosomatic medicine. Psychosomatic Medicine 70:214–31.
Lane, R. D. & Garfield, D. A. (2005) Becoming aware of feelings: Integration of cognitive-developmental, neuroscientific, and psychoanalytic perspectives. Neuropsychoanalysis 7:530.
Lane, R. D., McRae, K., Reiman, E. M., Chen, K., Ahern, G. L. & Thayer, J. F. (2009) Neural correlates of heart rate variability during emotion. NeuroImage 44:213–22.
Lane, R. D., Weihs, K. L. (2010) Freud's antiquities. Psychodynamic Practice 16:7778.
Lang, P. J., Cuthbert, B. N. & Bradley, M. M. (1998) Measuring emotion in therapy: Imagery, activation and feeling. Behavior Therapy 29:655–74.
LeDoux, J. (1996) The emotional brain: The mysterious underpinnings of emotional life. Simon and Schuster.
Leichsenring, F. & Rabung, S. (2008) Effectiveness of long-term psychodynamic psychotherapy: A meta-analysis. Journal of the American Medical Association 300(13):1551–65.
Levenson, R. W. (1994) Human emotion: A functional view. In: The nature of emotion – fundamental questions, ed. Elkman, P. & Davidson, R. J., pp. 123–26. Oxford University Press.
Levine, H. B. (2012) The colourless canvas: Representation, therapeutic action and the creation of mind. The International Journal of Psychoanalysis 93:607–29.
Liberzon, I. & Sripada, C. S. (2008) The functional neuroanatomy of PTSD: A critical review. Progress in Brain Research 167:151–69.
Luborsky, L. (1984) Principles of psychoanalytic psychotherapy: A manual for supportive-expressive treatment. Basic Books.
Luborsky, L., Rosenthal, R., Diguer, L., Andrusyna, T., Berman, J. S., Levitt, J. T., Seligman, D. A. & Krause, E. D. (2002) The Dodo Bird Verdict is alive and well – mostly. Clinical Psychology: Science and Practice 9(1):212.
Luborsky, L., Singer, B. & Luborsky, L. (1975) Comparative studies of psychotherapy. Archives of General Psychiatry 32:9951008.
Lupien, S. J., Friocco, A., Wan, N., Maheu, F., Lord, C., Schramek, T. & Tu, M. T. (2005) Stress hormones and human memory function across the lifespan. Psychoneuroendochrinology 30:225–42.
MacLennan, N. (1996) Counseling for managers. Gower.
Maren, S. (1999) Long term potentiation in the amygdala: A mechanism for emotional learning and memory. Trends in Neuroscience 22:561–67.
Maren, S. (2011) Seeking a spotless mind: Extinction, deconsolidation, and erasure of fear memory. Neuron 70:830–45.
Markus, H. & Wurf, E. (1987) The dynamic self-concept: A social psychological perspective. Annual Review of Psychology 38:299337.
Martin, L. L. & Tesser, A. (1989) Toward a motivational and structural theory of ruminative thought. In: Unintended thought, ed. Uleman, J. S. & Bargh, J. A., pp. 306–26. Guilford.
McGaugh, J. L. (2000) Memory: A century of consolidation. Science 287:248–51.
McGaugh, J. L. (2003) Memory and emotion: The making of lasting memories. Columbia University Press.
McGaugh, J. L. & Roozendaal, B. (2002) Role of adrenal stress hormones in forming lasting memories in the brain. Current Opinions in Neurobiology 12:205–10.
McNally, R. J. (2005) Remembering trauma. Harvard University Press.
McNally, R. J., Bryant, R. A. & Ehlers, A. (2003) Does early psychological intervention promote recovery from posttraumatic stress? Psychological Science in the Public Interest 4(2):4579.
Mednick, S. C., Cai, D. J., Kanady, J. & Drummond, S. P. A. (2008) Comparing the benefits of caffeine, naps and placebo on verbal, motor, and perceptual memory. Behavioural Brain Research 193:7986.
Meissner, W. W. (1998) Neutrality, abstinence, and the therapeutic alliance. Journal of the American Psychoanalytic Association 46(4):1089–128.
Mikics, E., Baranyi, J. & Haller, J. (2008) Rats exposed to traumatic stress bury unfamiliar objects – a novel measure of hyper-vigilance in PTSD models? Physiology and Behavior 94:341–48.
Milad, M. R. & Quirk, G. J. (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420:70–4.
Missirlian, T. M., Toukmanian, S. G., Warwar, S. H. & Greenberg, L. S. (2005) Emotional arousal, client perceptual processing, and the working alliance in experiential psychotherapy for depression. Journal of Consulting and Clinical Psychology 73:861–71.
Modell, A. H. (2010) The unconscious as a knowledge processing center. In: Knowing, not-knowing and sort-of-knowing: psychoanalysis and the experience of uncertainty, ed. Petrucelli, J., pp. 4561. Karnac.
Monsen, J., Odland, T., Faugli, A., Daae, E. & Eilertsen, D. E. (1995) Personality disorders and psychosocial changes after intensive psychotherapy: A prospective follow-up study of an outpatient psychotherapy project, 5 years after end of treatment. Scandinavian Journal of Psychology 36:256–68.
Moscovitch, M. & Nadel, L. (1999) Multiple-trace theory and semantic dementia: Response to K. S. Graham (1999) Trends in Cognitive Sciences 3:87–9.
Moscovitch, M., Nadel, L., Winocur, G., Gilboa, A. & Rosenbaum, S. (2006) The cognitive neuroscience of remote episodic, semantic and spatial memory. Current Opinion in Neurobiology 16:179–90.
Murty, V. P., Ritchey, M., Adcock, R. A. & Labar, K. S. (2010) fMRI studies of successful emotional memory encoding: A quantitative meta-analysis. Neuropsychologia 48(12):3459–69.
Nadel, L., Campbell, J. & Ryan, L. (2007) Autobiographical memory retrieval and hippocampal activation as a function of repetition and the passage of time. Neural Plasticity 2007:90472. Available at:
Nadel, L. & Jacobs, W. J. (1998) Traumatic memory is special. Current Directions in Psychological Science 7:154–57.
Nadel, L. & Moscovitch, M. (1997) Memory consolidation, retrograde amnesia and the hippocampal complex. Current Opinion in Neurobiology 7:217–27.
Nadel, L., Samsonovich, A., Ryan, L. & Moscovitch, M. (2000) Multiple trace theory of human memory: Computational, neuroimaging, and neuropsychological results. Hippocampus 10(4):352–68.
Nader, K., Schafe, G. E. & Le Doux, J. E. (2000) Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406:722–6.
Neisser, U. (1981) John Dean's memory: A case study. Cognition 9:122.
Neisser, U. & Harsch, N. (1992) Phantom flashbulbs: False recollections of hearing the news about Challenger. In: Affect and accuracy in recall: Studies of “flashbulb” memories, vol. 4, ed. Winograd, E. & Neisser, U., pp. 931. Cambridge University Press.
Newman, K. M. (2013) A more usable Winnicott. Psychoanalytic Inquiry 33:5963.
Nolen-Hoeksema, S. (2004) The response styles theory. In: Depressive rumination, ed. Papageorgiou, C. & Wells, A., pp. 107–24. Wiley.
Orlinsky, D. E. & Howard, K. I. (1986) Process and outcome in psychotherapy. In: Handbook of psychotherapy and behavior change, ed. Garfield, S. & Bergin, A.. Wiley.
Ost, J., Vrij, A., Costall, A. & Bull, R. (2002) Crashing memories and reality monitoring: Distinguishing between perceptions, imaginations and “false memories.Applied Cognitive Psychology 16(2):125–34.
Otto, M. W., McHugh, K. & Kantak, K. M. (2010) Combined pharmacotherapy and cognitive-behavioral therapy for anxiety disorders: Medication effects, glucocorticoids, and attenuated treatment outcomes. Clinical Psychology Science and Practice 17:91103.
Paivio, S. C., Hall, I. E., Holowaty, K. A. M., Jellis, J. B. & Tran, N. (2001) Imaginal confrontation for resolving child abuse issues. Psychotherapy Research 11:433–53.
Paivio, S. C. & Laurent, C. (2001) Empathy and emotion regulation: Reprocessing memories of childhood abuse. Journal of Clinical Psychology 57(2):213–26.
Pascual-Leone, A. & Greenberg, L. S. (2007) Emotional processing in experiential therapy: Why “the only way out is through.” Journal of Consulting and Clinical Psychology 75(6):875–87. Available at:
Payne, J. D., Jackson, E. D., Hoscheidt, S., Ryan, L., Jacobs, W. J. & Nadel, L. (2007) Stress administered prior to encoding impairs neutral but enhances emotional long-term episodic memories. Learning & Memory 14:861–8.
Payne, J. D., Jackson, E. D., Ryan, L., Hoscheidt, S., Jacobs, J. W. & Nadel, L. (2006) The impact of stress on neutral and emotional aspects of episodic memory. Memory 14:116.
Pezdek, K. (2003) Event memory and autobiographical memory for the events of September 11, 2001. Applied Cognitive Psychology 17:1033–45.
Phelps, E. A. (2004) Human emotion and memory: Interactions of the amygdala and hippocampal complex. Current Opinion in Neurobiology 14(2):198202. Available at:
Pilero, S. (2004) Patients reflect upon their affect-focused, experiential psychotherapy: A retrospective study. Unpublished doctoral dissertation for Adelphi University.
Pitman, R. K., Sanders, K. M., Zusman, R. M., Healy, A. R., Cheema, F., Lasko, N. B., Cahill, L. & Orr, S. P. (2002) Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry 51:189–92.
Quirin, M. R. & Lane, R. D. (2012) The construction of emotional experience requires the integration of implicit and explicit emotional processes. Behavioral and Brain Sciences 35(3):159–60.
Rachman, A. W. (1997) Sandor Ferenczi: The psychotherapist of tenderness and passion. Jason Aronson.
Rachman, A. W. (2007) Sandor Ferenczi's contributions to the evolution of psychoanalysis. Psychoanalytic Psychology 24:7496.
Rachman, S. (1980) Emotional processing. Behaviour Research and Therapy 18:5160.
Ray, R., Ochsner, K., Cooper, J., Robertson, E., Gabrieli, J. & Gross, J. (2005) Individual differences in trait rumination and the neural systems supporting cognitive reappraisal. Cogitive, Affective, and Behavioral Neuroscience 5:156–68.
Reber, A. S. (1989) Implicit learning and tacit knowledge. Journal of Experimental Psychology: General 118:219–35.
Reber, A. S. (1996) Implicit learning and tacit knowledge: An essay on the cognitive unconscious. Oxford Press.
Roozendaal, B., McEwen, B. S. & Chattarji, S. (2009) Stress, memory and the amygdala. Nature Reviews Neuroscience 10:423433.
Roozendaal, B., Okuda, S., Van der Zee, E. A. & McGaugh, J. L. (2006) Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala. Proceedings of the National Academy of Sciences 103:6741–46.
Rubin, D. C., Berntsen, D. & Johansen, M. K. (2008) A memory-based model of posttraumatic stress disorder: Evaluating basic assumptions underlying the PTSD diagnosis. Psychological Review 115:9851011.
Ryan, L., Cox, C., Hayes, S. M. & Nadel, L. (2008a) Hippocampal activation during episodic and semantic memory retrieval: Comparing category production and category cued recall. Neuropsychologia 46:2109–21.
Ryan, L., Hoscheidt, S. & Nadel, L. (2008b) Perspectives on episodic and semantic memory retrieval. In: Handbook of episodic memory (Handbook of behavioral neuroscience), ed. Dere, E., Easton, A., Huston, J. & Nadel, L., pp. 518. Elsevier.
Ryan, L., Lin, C. Y., Ketcham, K. & Nadel, L. (2010) The role of medial temporal lobe in retrieving spatial and nonspatial relations from episodic and semantic memory. Hippocampus 20:11–8.
Ryan, L., Nadel, L., Keil, K., Putnam, K., Schnyer, D., Trouard, T. & Moscovitch, M. (2001) Hippocampal complex and retrieval of recent and very remote autobiographical memories: Evidence from functional magnetic resonance imaging in neurologically intact people. Hippocampus 11:707–14.
Schacter, D. L., Chiu, Y. P. & Ochsner, K. N. (1993) Implicit memory: A selective review. Annual Review of Neuroscience 16:159–82.
Schacter, D. L. & Graf, P. (1989) Modality specificity of implicit memory for new associations. Journal of Experimental Psychology: Learning, Memory, and Cognition 15:312.
Schacter, D. L. & Tulving, E. (1994) What are the memory systems of 1994? In: Memory systems 1994, ed. Schacter, D. L. & Tulving, E., pp. 138. MIT Press.
Schacter, D. L., Wagner, A. D. & Buckner, R. L. (2000) Memory Systems of 1999. In: The Oxford handbook of memory, ed. Tulving, E., Craik, F. I., pp. 627–43. Oxford University Press.
Schimek, J. G. (1975) A critical re-examination of Freud's concept of unconscious mental representation. International Review of Psycho-Analysis 2:171–87.
Schwabe, L., Nader, K., Wolf, O. T., Beaudry, T. & Pruessner, J. C. (2012) Neural signature of reconsolidation impairments by propranolol in humnans. Biological Psychiatry 71(4):380–86.
Seger, C. A. & Miller, E. K. (2010) Category learning in the brain. Annual Review of Neuroscience 33:203–19.
Shedler, J. (2010) The efficacy of psycho dynamic therapy. American Psychologist 65(2):98109.
Silberschatz, G., Fretter, P. B. & Curtis, J. T. (1986) How do interpretations influence the process of psychotherapy? Journal of Consulting and Clinical Psychology 54:646–52.
Soravia, L. M., Heinrichs, M., Aerni, A., Maroni, C., Schelling, G., Ehlert, U., Roozendaal, B. & de Quervain, D. J. (2006) Glucocorticoids reduce phobic fear in humans. Proceedings of the National Academy of Sciences of the United States of America 103:5585–90.
Spezzano, C. (1993) Affect in psychoanalysis: A clinical synthesis. Analytic Press.
Squire, L. R. & Alvarez, P. (1995) Retrograde amnesia and memory consolidation: A neurobiological perspective. Current Opinions in Neurobiology 5:169–77.
Steklis, H. D. & Lane, R. (2013) The unique human capacity for emotional awareness: Psychological, neuroanatomical, comparative and evolutionary perspectives. In: Emotions of animals and humans, ed. Watanabe, S. & Kuczaj, S., pp. 165205. Springer.
Stern, D. B. (1983) Unformulated experience: From familiar chaos to creative disorder. Contemporary Psychoanalysis 19:7199.
Stern, D. N. (2004) The present moment in psychotherapy and everyday life. Norton.
Talarico, J., LaBar, K. S. & Rubin, D. C. (2004) Emotional intensity predicts autobiographical memory experience. Memory and Cognition 32:1118–32.
Talarico, J. M. & Rubin, D. C. (2003) Confidence, not consistency, characterizes flashbulb memories. Psychological Science 14(5):455–61.
Teasdale, J. D., Moore, R. G., Hayhurst, H., Pope, M., Williams, S. & Segal, S. V. (2002) Metacognitive awareness and prevention of relapse in depression: Empirical evidence. Journal of Consulting and Clinical Psychology 70(2):275–87.
Tenenbaum, E. M. & Reese, B. (2007) Memory-altering drugs: Shifting the paradigm of informed consent. American Journal of Bioethics 7:4042.
Thayer, J. F., Åhs, F., Fredriskon, M., Sollers, J. & Wager, T. D. (2012) A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience and Behavioral Reviews 36(2):747–56.
Tribl, G. G., Wetter, T. C. & Schredl, M. (2013) Dreaming under antidepressants: A systematic review on evidence in depressive patients and healthy volunteers. Sleep Medicine Reviews 17(2):133–42.
Tulving, E. (1983) Elements of episodic memory. Clarendon.
Tulving, E. (2002) Episodic memory: From mind to brain. Annual Review of Psychology 53:125.
Tulving, E. (2005) Episodic memory and autonoesis: Uniquely human? In: The missing link in cognition: Origins of self-selective consciousness, ed. Terrace, H. S. & Metcalfe, J., pp. 356. Oxford University Press.
Tulving, E. & Markowitsch, H. J. (1998) Episodic and declarative memory: Role of the hippocampus. Hippocampus 8:198204.
Van der Kolk, B. A. (1995) The body, memory, and the psychobiology of trauma. In: Sexual abuse recalled: Treating trauma in the era of the recovered memory debate, ed. Alpert, J. L., pp. 2960. Aronson.
Van der KolK, B. A. & Van der Hart, O. (1989) Pierre Janet and the breakdown of adaptation in psychological trauma. American Journal of Psychiatry 146(12):1530–40.
Van Giezen, A. E., Arensman, E., Spinhoven, P. & Wolters, G. (2005) Consistency of memory for emotionally arousing events. Clinical Psychology Review 25:935–53.
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V. & Arnsten, A. F. T. (2007) Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 10:376–84.
Vocks, S., Legenbauer, T., Wachter, A., Wucherer, M. & Kosfelder, J. (2007) What happens in the course of body exposure? Emotional, cognitive and physiological reactions to mirror confrontation in eating disorders. Journal of Psychosomatic Research 62:231–39.
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S. & Chattarji, S. (2002) Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. The Journal of Neuroscience 22:6810–8.
Walker, M. P. (2009) The role of sleep in cognition and emotion. Annals of the New York Academy of Sciences 1156:168–97.
Watkins, E. R. (2008) Constructive and unconstructive repetitive thought. Psychological Bulletin 134:163206.
Watson, J. P. & Marks, I. M. (1971) Relevant and irrelevant fear in flooding – a crossover study of phobic patients. Behavior Therapy 2:275293.
Welling, H. (2012) Transformative emotional sequence: Towards a common principle of change. Journal of Psychotherapy Integration 22(2):100–36.
Wilson, M. A. & McNaughton, B. L. (1994) Reactivation of hippocampal ensemble memories during sleep. Science 265:676–9.
Winkielman, P. & Berridge, K. (2004) Unconscious emotion. Current directions in Psychological Science 13(3):120–23.
Zajonc, R. B. (2000) Feeling and thinking: Closing the debate over the independence of affect. In: Feeling and thinking: The role of affect in social cognition, ed. Forgas, J. P., pp. 3158. Cambridge University Press.


Memory reconsolidation, emotional arousal, and the process of change in psychotherapy: New insights from brain science

  • Richard D. Lane (a1), Lee Ryan (a2), Lynn Nadel (a3) and Leslie Greenberg (a4)


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