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Effects of hydroxytyrosol-enriched sunflower oil consumption on CVD risk factors

  • Miguel Vázquez-Velasco (a1), Ligia Esperanza Díaz (a2), Rocío Lucas (a1), Sonia Gómez-Martínez (a2), Sara Bastida (a1), Ascensión Marcos (a2) and Francisco J. Sánchez-Muniz (a1)...
Abstract

Inclusion of biophenols in traditional foods transforms them into functional foods that may help to decrease CVD risk. The aim of the present study was to determine whether the consumption of hydroxytyrosol-enriched sunflower oil (HSO) improves certain CVD biomarker values. A total of twenty-two healthy volunteers participated in a cross-over study involving two 3-week periods, separated by a 2-week washout period, in which volunteers consumed 10–15 g/d of either HSO (45–50 mg/d of hydroxytyrosol) or non-enriched (control) sunflower oil. Total cholesterol, LDL-cholesterol, HDL-cholesterol, arylesterase activity, oxidised LDL and soluble vascular cell adhesion molecule (sVCAM-1) levels were measured in the plasma obtained at the beginning and at the end of each treatment period. The HSO group displayed a significantly higher level (P < 0·01) of arylesterase activity and significantly lower levels of oxidised LDL and sVCAM-1 (both P < 0·05) than the control group. These results suggest that HSO may help prevent CVD.

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Corresponding author
*Corresponding author: Professor F. J. Sánchez-Muniz, fax +34 91 3941810, email frasan@farm.ucm.es
References
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1 Waterman E & Lockwood B (2007) Active components and clinical applications of olive oil. Alt Med Rew 12, 331342.
2 Miró-Casas E, Covas M-I, Fitó M, et al. (2003) Tyrosol and hydroxytyrosol are absorbed from moderate and sustained dosis of virgin olive oil in humans. Eur J Clin Nutr 57, 186190.
3 Fitó M, de la Torre R, Farré-Albaladejo M, et al. (2007) Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review. Ann 1st Super Sanità 43, 375381.
4 Cornwell D & Jiyan M (2008) Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinine adducts. J Agric Food Chem 56, 87748786.
5 Rietjens S, Bast A & Haenen G (2007) New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol. J Agric Food Chem 55, 76097614.
6 González-Santiago M, Martín-Bautista E, Carrero JJ, et al. (2006) One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development. Atherosclerosis 188, 3542.
7 Covas M-I, Nyyssönen K, Poulsen HE, et al. (2006) The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med 145, 333341.
8 Carluccio MA, Ancora MA, Massaro M, et al. (2007) Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants. Am J Physiol Heart Circ Physiol 293, 23442354.
9 González-Correa JA, Navas MD, Muñoz-Marín J, et al. (2008) Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid. J Agric Food Chem 56, 78727876.
10 Ruano J, López-Miranda J, de la Torre R, et al. (2007) Intake of phenol-rich virgin olive oil improves the postprandial prothrombotic profile in hypercholesterolemic patients. Am J Clin Nutr 86, 341346.
11 Nus M, Sánchez-Muniz FJ & Sánchez-Montero JM (2006) A new method for the determination of arylesterase activity in human serum using simulated body fluid. Atherosclerosis 188, 155159.
12 Nus M, Sánchez-Muniz FJ & Sánchez-Montero JM (2008) Arilesterasa. Aspectos metodológicos y funcionales en una enzima clave en la enfermedad cardiovascular. Parte I (Arylesterase. Methodological and functional aspects of a key enzyme in cardiovascular disease. Part I). An R Acad Nac Farm 74, 527.
13 Mackness B, Durrington PN, McElduff P, et al. (2003) Low paraoxonase activity predicts coronary events in the Caerphilly prospective. Circulation 107, 27752779.
14 Tomás M, Sentí M, García-Faria F, et al. (2000) Effect of simvastatin therapy on paraoxonase activity and related lipoproteins in familial hypercholesterolemic patients. Atheroscler Thromb Vasc Biol 20, 21132119.
15 Canales A & Sánchez-Muniz FJ (2003) La paraoxonasa, ¿algo más que una enzima? (Paraoxonase, something more than an enzyme?). Med Clin (Barc) 121, 537548.
16 Abbott CA, Mackness MI, Kumar S, et al. (1995) Serum paraoxonase activity, concentration and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins. Atheroscler Thromb Vasc Biol 15, 18121818.
17 Quiles JL, Huertas JR, Mañas M, et al. (2001) Dietary fat type and regular exercise affect mitochondrial composition and function depending on specific tissue in rat. J Bioenerg Biomembr 33, 127143.
18 Mensink RP & Katan MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A metaanalysis of 27 trials. Arterioscler Thromb 12, 911919.
19 Moreiras O, Carbajal A, Cabrera L, et al. (2009) Tablas de composición de alimentos (Food Composition Tables). Madrid: Pirámide.
20 Friedewald WT, Levy RI & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 18, 499502.
21 Aranceta J (2001) Spanish food patterns. Public Health Nutr 4, 13991402.
22 de la Torre-Carbot K, Chávez-Servín JL, Jaúregui O, et al. (2010) Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J Nutr 140, 501508.
23 Aviram M, Rosenblat M, Bisgaier CL, et al. (1998) Paraoxonase inhibits high density lipoproteins (HDL) oxidation and preserves its functions, a possible peroxidative role for paraoxonase. J Clin Invest 101, 15811590.
24 Ross R (1999) Atherosclerosis: an inflammatory disease. N Engl J Med 340, 115126.
25 Orr AW, Hastings NE, Blackman BR, et al. (2010) Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res 47, 168180.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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