Editorial

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The Future is Now – Using the Lessons Learned from the ACTIV COVID-19 Therapeutics Trials to Create an Inclusive and Efficient Clinical Trials Enterprise

Stacey J. Adam, Sarah E. Dunsmore, Lisa H. Merck, Sarah W. Read, and Yves Rosenberg

 Published online by Cambridge University Press:  15 October 2024

Review Article

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Overview of ACTIV trial-specific lessons learned

Ruxandra Draghia-Akli, Sarah W. Read, and Eric A. Hughes

Published online by Cambridge University Press:  15 October 2024

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Preparing better: Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) therapeutics trials lessons learned: A call to the future

Stacey J. Adam, Timothy G. Buchman, Judith S. Currier, Ruxandra Draghia-Akli, Josh P. Fessel, Elizabeth S. Higgs, Eric A. Hughes, Lisa LaVange, Joseph P. Menetski, Sarah W. Read, Yves Rosenberg, Randall Tressler and ACTIV Therapeutics-Clinical Working Group

Published online by Cambridge University Press:  15 October 2024

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ACTIV trials: Lessons learned in trial design in the setting of an emergent pandemic

Maryam Keshtkar-Jahromi, Kevin J. Anstrom, Christina Barkauskas, Samuel M. Brown, Eric S. Daar, William Fischer, Kevin W. Gibbs, Elizabeth S. Higgs, Michael D. Hughes, Prasanna Jagannathan, Lisa LaVange, Christopher J. Lindsell, Seema U. Nayak, Roger Paredes, Mahesh Parmar, Ithan D. Peltan, Michael Proschan, Matthew S. Shotwell, David M. Vock, Tammy Yokum and Stacey J. Adam

Published online by Cambridge University Press:  15 October 2024

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ACTIV trials: cross-trial lessons learned for master protocol implementation

Maryam Keshtkar-Jahromi, Stacey J. Adam, Indira Brar, Lucy K. Chung, Judith S. Currier, Eric S. Daar, Victoria J. Davey, Eileen T. Denning, Annetine C. Gelijns, Elizabeth S. Higgs, Prasanna Jagannathan, Arzhang Cyrus Javan, Tomas O. Jensen, Nikolaus Jilg, Ioannis Kalomenidis, Peter Kim, Seema U. Nayak, Matthew Newell, Babafemi O. Taiwo, Tammy Yokum and Yvette Delph

Published online by Cambridge University Press:  15 October 2024

Perspective

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Lessons learned from COVID-19 to overcome challenges in conducting outpatient clinical trials to find safe and effective therapeutics for the next infectious pandemic

Minn A. Oh, Judith Currier, Akram Khan, Eleftherios Mylonakis, Matthew Newell, Rachel Bender Ignacio, Nick Jilg, Basmah Safdar, Lisa H. Merck and Davey M. Smith

Published online by Cambridge University Press:  15 October 2024

Research Article

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Lessons learned from the conduct of inpatient clinical trials in a pandemic

Jane A. O’Halloran, Jeremy R. Beitler, Lucy K. Chung, Mamta K. Jain, Akram Khan, Lisa H. Merck, Ahmad Mourad, Minn A. Oh, Shweta Sharma, Tammy Yokum and Seema U. Nayak

Published online by Cambridge University Press:  15 October 2024

Special Communication

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The statistical design and analysis of pandemic platform trials: Implications for the future

Christopher J. Lindsell, Matthew Shotwell, Kevin J. Anstrom, Scott Berry, Erica Brittain, Frank E. Harrell, Nancy Geller, Birgit Grund, Michael D. Hughes, Prasanna Jagannathan, Eric Leifer, Carly B. Moser, Karen L. Price, Michael Proschan, Thomas Stewart, Sonia Thomas, Giota Touloumi and Lisa LaVange

Published online by Cambridge University Press:  15 October 2024

Review Article

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Engaging communities in therapeutics clinical research during pandemics: Experiences and lessons from the ACTIV COVID-19 therapeutics research initiative

David A. Wohl, Stacey J. Adam, Kevin W. Gibbs, Ari L. Moskowitz, Thomas L. Ortel, Upinder Singh, Nikolaus Jilg, Teresa H. Evering, William A. Fischer II, Babafemi O. Taiwo, Eric S. Daar, Christopher J. Lindsell, Susanna Naggie, Russell L. Rothman, Sarah E. Dunsmore, M. Patricia McAdams, Julia Vail and Dushyantha Jayaweera

Published online by Cambridge University Press:  15 October 2024

Special Communication

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Practical application of good participatory practices for trials of emerging pathogens: Developing materials for use in ACTIV-3, -3b, and ACTIV-associated COVID-19 trials

Paola del Carmen Guerra-de-Blas, Rubria Marines-Price, Olga Milman, Danae Deal, Jonathan Marchand, Jessica Linton, Sue Meger, John Rule, Thomas L. Holland, Jonathan Kitonsa, Yvette Delph and for the INSIGHT OTAC, ACTIV-3 TICO, ACTIV-3 substudy VATICO, and ACTIV-3b TESICO Study Groups

Published online by Cambridge University Press:  15 October 2024