Over the years the ‘depot clinic’ has become little more than a conveyor belt for patients to receive depot medication from nursing staff within a hospital setting. Indeed, the concept of the depot clinic has not significantly changed since the introduction of neuroleptic medication in the 1950s. A lack of review of the service has resulted in suboptimal treatment, unchecked side-effects and a lack of monitoring of physical health. We describe the redesign of a depot service within an inner city community service, with emphasis on evidence-based practice, regular, patient-centred reviews, support, health promotion and education.