From its founding in 1938 onwards, the activities of the Confederation of Latin American Workers (CTAL) were rooted in anti-imperialist struggle. Initially, this was in response to the plundering of Latin America in the service of US economic interests, while later anti-imperialist efforts were directed against the hegemony that Europe and the US exerted over markets and territories in Africa and Asia. In the immediate post-war period, the CTAL engaged in a markedly anti-imperialist discourse. The confederation established solidarity alliances and trade union campaigns committed to supporting causes in distant, culturally diverse places, because they were considered part of the same history of dependence, neglect, and exclusion that had to be overcome to build autonomous nations. This article covers meetings between trade union leaders from different continents, as documented in letters, magazine and newspaper articles, conference proceedings, and the records of workers’ organizations. Working through the CTAL and the World Federation of Trade Unions, these individuals disseminated their beliefs and sought to achieve widespread mobilization for their union and political struggles, with the goal of eradicating imperialism from the Americas, Africa, and Asia.