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Polygenic scores, and the genome-wide association studies they derive from, will have difficulty identifying genes that predispose one to develop a social behavioral trait

Published online by Cambridge University Press:  11 September 2023

Edward Fox Open the ORCID record for Edward Fox [Opens in a new window]
Edward Fox*
Affiliation:
Department of Psychological Science, Purdue University, West Lafayette, IN, USA au_gc@psych.purdue.edu https://www.purdue.edu/hhs/psy/directory/faculty/Fox_Edward.html
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Abstract

Polygenic scores (PGSs) have several limitations. They are confounded with environmental effects on behavior and cannot be used to study how mutations affect brain function and behavior. For this, mutations with large effects, which often arise in only one geographical population are needed. Genome-wide association studies (GWASs), commonly used for identifying mutations, have difficulty detecting these mutations. A strategy that overcomes this challenge is discussed.

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Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 46 , 2023 , e214
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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