Handbook of Experimental Neurology: Methods and Techniques in Animal Research

doi:10.1017/CBO9780511541742

Basic relevant information on methodologies used in neurological disease models can be extremely hard to find. Originally published in 2006, this important reference work contains 30 chapters from over 60 internationally recognized scientists and covers every major methodology and disease model used in neuroscience research. Divided into two major sections, the first deals with general methodologies in neuroscience research covering topics from animal welfare and ethical issues to surgical procedures, post-operative care and behavioral testing. Section two covers every major disease model including traumatic brain injury, ischemia and stroke, to Parkinson's, motor neurone disease, epilepsy and sleep disorders. Delivering critical methodological information and describing small animal models for almost all major neurological diseases, this book forms an essential reference for anyone working in neuroscience, from beginning students to experienced researchers and medical professionals.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vii
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List of contributors
pp viii-xiv
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Part I - Principles and general methods
pp 1-2
- By Turgut Tatlisumak, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland, Marc Fisher, Department of Neurology University of Massachusetts Medical School UMASS/Memorial Health Care 119 Belmont Street Worcester, MA 01605 USA
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1 - Introduction: Animal modeling – a precious tool for developing remedies to neurological diseases
pp 3-5
- By Turgut Tatlisumak, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland, Marc Fisher, Department of Neurology University of Massachusetts Medical School UMASS/Memorial Health Care 119 Belmont Street Worcester, MA 01605 USA
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2 - Ethical issues, welfare laws, and regulations
pp 6-18
- By David Whittaker, Huntingdon Life Sciences Ltd Woolley Road Alconbury Huntingdon PE28 4HS UK
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3 - Housing, feeding, and maintenance of rodents
pp 19-32
- By Robert W. Kemp, AstraZeneca Inc. Alderley Park Macclesfield SK10 4TF UK
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4 - Identification of individual animals
pp 33-39
- By Turgut Tatlisumak, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland, Danial Strbian, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland
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5 - Analgesia, anesthesia, and postoperative care in laboratory animals
pp 40-66
- By Naoya Masutomi, Toxicology Laboratory Mitsubishi Pharma Corporation 1-1-1 Kazusakamatari Kisarazu, Chiba 292-0818 Japan, Makoto Shibutani, Division of Neuropathology National Institute of Health Sciences 1-18-1 Kamiyoga, Setagayu-ku Tokyo 158-8501 Japan
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6 - Euthanasia in small animals
pp 67-74
- By Turgut Tatlisumak, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland
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7 - Various surgical procedures in rodents
pp 75-113
- By René Remie, Department of Biomonitoring and Sensoring University Center for Pharmacy Groningen University Antonius Deusinglaan 1 9714 AW Groningen Netherlands
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8 - Genetically engineered animals
pp 114-131
- By Carolina M. Maier, Department of Neurosurgery and Neurological Sciences Stanford University Medical School 1201 Welch Rd MSLS P357 Stanford, CA 94305 USA, Lilly Hsieh, Department of Neurosurgery and Neurological Sciences Stanford University Medical School 1201 Welch Rd MSLS P357 Stanford, CA 94305 USA, Pak H. Chan, Department of Neurosurgery and Neurosciences Stanford University Medical Center Palo Alto, CA 93304 USA
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9 - Imaging in experimental neurology
pp 132-146
- By Marc Fisher, Department of Neurology University of Massachusetts Medical School UMASS/Memorial Health Care 119 Belmont Street Worcester, MA 01605 USA, Eng H. Lo, Departments of Neurology and Radiology Harvard Medical School Boston, MA 02115 USA, Michael Lev, Department of Radiology Harvard Medical School Boston, MA 02115 USA
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10 - Safety in animal facilities
pp 147-153
- By Tarja Kohila, University of Helsinki 00014 Helsinki Finland
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11 - Behavioral testing in small-animal models: ischemic stroke
pp 154-172
- By Larry B. Goldstein, Department of Neurology Duke Center for Cerebrovascular Disease Duke University Medical Center P.O. Box 3651 Durham, NC 27710 USA
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12 - Methods for analyzing brain tissue
pp 173-180
- By Päivi Liesi, Department of Biosciences University of Helsinki P.O. Box 65 Viikinkaari 1 00014 Helsinki Finland
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13 - Targeting molecular constructs of cellular function and injury through in vitro and in vivo experimental models
pp 181-211
- By Zhao Zhong Chong, Departments of Neurology and Anatomy and Cell Biology Centers for Molecular Medicine and Institute for Environmental Health Sciences Wayne State University School of Medicine 8C-1 UHC 4201 St. Antoine Detroit, MI 48201 USA, Faqi Li, Departments of Neurology and Anatomy and Cell Biology Centers for Molecular Medicine and Institute for Environmental Health Sciences Wayne State University School of Medicine 8C-1 UHC 4201 St. Antoine Detroit, MI 48201 USA, Kenneth Maiese, Departments of Neurology and Anatomy and Cell Biology Centers for Molecular Medicine and Institute for Environmental Health Sciences Wayne State University School of Medicine 8C-1 UHC 4201 St. Antoine Detroit, MI 48201 USA
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14 - Neuroimmunology and immune-related neuropathologies
pp 212-238
- By Bao-Guo Xiao, Department of Neurology Karolinska Institute and Huddinge University Hospital M 98, 14186 Huddinge Stockholm Sweden, Hans Link, Department of Neurology Karolinska Institute and Huddinge University Hospital M 98, 14186 Huddinge Stockholm Sweden
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15 - Animal models of sex differences in non-reproductive brain functions
pp 239-256
- By George T. Taylor, Behavioral Neuroscience Group University of Missouri – St. Louis 8001 Natural Bridge Rd. St. Louis, MO 63121 USA, Juergen Weiss, Center for Biomedicine University of Heidelberg INF 347 D-69120 Heidelberg Germany, Frank Zimmermann, Center for Biomedicine University of Heidelberg INF 347 D-69120 Heidelberg Germany
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16 - The ependymal route for central nervous system gene therapy
pp 257-268
- By Erica Butti, Neuroimmunology Unit San Raffaella Scientific Institute–DIBIT Via Olgettina 58 20132 Milano Italy, Gianvito Martino, Neuroimmunology Unit San Raffaele Scientific Institute–DIBIT Via Olgettina 58 20132 Milano Italy, Roberto Furlan, Neuroimmunology Unit San Raffaele Scientific Institute–DIBIT Via Olgettina 58 20132 Milano Italy
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17 - Neural transplantation
pp 269-308
- By Stephen B. Dunnett, School of Biosciences Cardiff University Museum Avenue P.O. Box 911 Cardiff CF10 3US UK, Eduardo M. Torres, School of Biosciences Cardiff University Museum Avenue P.O. Box 911 Cardiff CF10 3US UK, Monte A. Gates, School of Biosciences Cardiff University Museum Avenue P.O. Box 911 Cardiff CF10 3US UK, Rosemary A. Fricker-Gates, School of Biosciences Cardiff University Museum Avenue P.O. Box 911 Cardiff CF10 3US UK
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Part II - Experimental models of major neurological diseases
pp 309-310
- By Turgut Tatlisumak, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland, Marc Fisher, Department of Neurology University of Massachusetts Medical School UMASS/Memorial Health Care 119 Belmont Street Worcester, MA 01605 USA
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18 - Focal brain ischemia models in rodents
pp 311-328
- By Fuhai Li, Department of Neurology Duke University Medical Center P.O. Box 3651 Durham, NC 27710 USA, Turgut Tatlisumak, Department of Neurology Helsinki University Central Hospital Haartmaninkatu 4 00290 Helsinki Finland
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19 - Rodent models of global cerebral ischemia
pp 329-344
- By Julia Kofler, Department of Anesthesiology and Peri-Operative Medicine Oregon Health and Science University 3181 SW Sam Jackson Park Rd Mail Code L335 Portland, OR 97239 USA, Richard J. Traystman, Department of Anesthesiology and Peri-Operative Medicine Oregon Health and Science University 3181 SW Sam Jackson Park Rd Mail Code L335 Portland, OR 97239 USA
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20 - Rodent models of hemorrhagic stroke
pp 345-365
- By Fatima A. Sehba, Department of Neurosurgery Mount Sinai School of Medicine 1 Gustave L. Levy Place Box 1136 New York, NY 10029 USA, Joshua B. Bederson, Department of Neurosurgery Mount Sinai School of Medicine 1 Gustave L. Levy Place Box 1136 New York, NY 10029 USA
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21 - In vivo models of traumatic brain injury
pp 366-374
- By Ronen R. Leker, Laboratory of Molecular Biology Bldg 36, Room 3c12 National Institute for Neurological Disorders and Stroke National Institutes of Health Bethesda, MD 20892 USA, Shlomi Constantini, Department of Pediatric Neurosurgery Dana Children's Hospital Tel Aviv Medical Center Tel Aviv 64239 Israel
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22 - Experimental models for the study of CNS tumors
pp 375-392
- By Taichang Jang, Department of Neurology and Clinical Neurosciences Stanford University Medical Center Palo Alto, CA 93304 USA, Lawrence Recht, Department of Neurology and Clinical Neurosciences University of Stanford Medical School Palo Alto, CA 93304 USA
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23 - Experimental models for demyelinating diseases
pp 393-410
- By Jason M. Link, Portland Veterans Affairs Medical Center Oregon Health and Science University R&D-31 3710 SW US Veterans Hospital Rd Portland, OR 97239 USA, Richard E. Jones, Portland Veterans Affairs Medical Center Oregon Health and Science University R&D-31 3710 SW US Veterans Hospital Rd Portland, OR 97239 USA, Halina Offner, Portland Veterans Affairs Medical Center Oregon Health and Science University R&D-31 3710 SW US Veterans Hospital Rd Portland, OR 97239 USA, Arthur A. Vandenbark, Department of Neurology Tykeson Multiple Sclerosis Research Laboratory Veterans Affairs Medical Center Oregon Health and Science University Portland, OR 97239 USA
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24 - Animal models of Parkinson's disease
pp 411-437
- By Anumantha G. Kanthasamy, Department of Biomedical Sciences 2062 Veterinary Medicine Building Iowa State University Ames, IA 50011 USA, Siddharth Kaul, Department of Biomedical Sciences 2062 Veterinary Medicine Building Iowa State University Ames, IA 50011 USA
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25 - Animal models of epilepsy
pp 438-456
- By Ricardo M. Arida, Laboratory of Experimental Neurology Departments of Neurology and Neurosurgery Faculty of Medicine Federal University of São Paulo Rvo Botucatu 862 04023 São Paulo Brazil, Alexandre V. Silva, Laboratory of Experimental Neurology Departments of Neurology and Neurosurgery Faculty of Medicine Federal University of São Paulo Rvo Botucatu 862 04023 São Paulo Brazil, Margareth R. Priel, Laboratory of Experimental Neurology Departments of Neurology and Neurosurgery Faculty of Medicine Federal University of São Paulo Rvo Botucatu 862 04023 São Paulo Brazil, Esper A. Cavalheiro, Laboratory of Experimental Neurology Departments of Neurology and Neurosurgery Faculty of Medicine Federal University of São Paulo Rvo Botucatu 862 04023 São Paulo Brazil
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Methods and Techniques in Animal Research

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