In today’s climate, researchers may feel pressured to always adopt the most complex, cutting-edge research techniques. Although such techniques have advantages, they also have disadvantages. In this chapter, we walk the reader through each stage of the research process: developing research questions and hypotheses, recruiting participants, selecting a study methodology and associated statistics, and disseminating results. At each stage, we compare the relative strengths and weaknesses of what we call “Column A” approaches (i.e., relatively simple, tried-and-true research techniques) versus “Column B” approaches (i.e., newer and more complex techniques). We argue that the best overall solution, both for individual researchers and for the field as a whole, is to adopt a diverse mix of different techniques. Throughout, we consider how open science techniques might potentially aid in achieving a healthy balance between different approaches. We also suggest mechanisms whereby often-expensive Column B approaches could be made more widely accessible.