Spinal Tumors

doi:10.1017/9781108917339.019

Chapter 19 - Spinal Tumors

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press: 04 January 2024

Ziev B. Moses ,

Matthew Trawczynski and

Edited by

Florian Engert and

Farhana Akter: Affiliation:
Harvard University, Massachusetts
Nigel Emptage: Affiliation:
University of Oxford
Florian Engert: Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger: Affiliation:
University of California, San Francisco

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Summary

Tumors of the spine are a heterogeneous group of neoplasms involving the spinal column and spinal cord. They can be distinguished based on their location within the spine into three groups: intradural–intramedullary, intradural–extramedullary, and extradural. Another classification seeks to separate out these tumors based on their cell of origin, with primary spine tumors arising from either the spinal cord itself, its surrounding coverings including the leptomeninges, bone, cartilage, and soft tissue, or as secondary tumors arising from spinal involvement of a systemic neoplasm such as myeloma or as a metastasis from a distant site. This chapter seeks to discuss current evidence on the genetic, epigenetic, and cellular underpinnings of spine tumors with emphasis on the pathobiology and mechanisms underlying these neoplasms.

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Type: Chapter
Information: Neuroscience for Neurosurgeons , pp. 267 - 277

DOI: https://doi.org/10.1017/9781108917339.019 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2024

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