Benn, J, Arnold, G, Wei, I, et al. Using quality indicators in anaesthesia: feeding back data to improve care. Br J Anaesth. 2012; 109(1):80–91.CrossRefGoogle ScholarPubMed

Gan, TJ, Diemunsch, P, Habib, AS, et al. Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. Anesth Analg 2014; 118(1):85–113.CrossRefGoogle ScholarPubMed

Kapur, PA. The big “little problem”. Anesth Analg 1991; 73(3):243–5.Google ScholarPubMed

Apfel, CC Philip, PB, Cakmakkaya, OS, et al. Who is at risk for postdischarge nausea and vomiting after ambulatory surgery? Anesthesiology 2012; 86:475–86.Google Scholar

Carr, AS, Courtman, S, Holtby, H, et al. Guidelines on the Prevention of Post-operative Vomiting in children: Association of Paediatric Anaesthetists of Great Britain & Ireland, 2009. http://www.apagbi.org.uk/sites/default/files/APA_Guidelines_on_the_Prevention_of_Postoperative_Vomiting_in_Children.pdf (accessed September 17, 2014).Google Scholar

Borison, HL, Wang, SC. Physiology and pharmacology of vomiting. Pharmacol Rev 1953; 5:193–230.Google ScholarPubMed

Creeley, CE, Olney, JW. The young: neuroapoptosis induced by anesthetics and what to do about it. Anesth Analg 2010; 110(2):442–8.CrossRefGoogle Scholar

Apfel, CC, Kranke, P, Katz, MH, et al. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth 2002; 88:659–68.CrossRefGoogle Scholar

Apfel, CC, Kranke, P, Eberhart, LH. Comparison of surgical site and patient’s history with a simplified risk score for the prediction of postoperative nausea and vomiting. Anaesthesia 2004; 59:1078–82.CrossRefGoogle ScholarPubMed

Eberhart, LH, Geldner, G, Kranke, P, et al. The development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. Anesth Analg 2004; 99(6):1630–7.Google ScholarPubMed

Kranke, P, Eberhart, LH, Toker, H, et al. A prospective evaluation of the POVOC score for the prediction of postoperative vomiting in children. Anesth Analg 2007 105(6):1592–7.CrossRefGoogle ScholarPubMed

Bourdaud, N, Devys, J-M, Bientz, J, et al. Development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients: the VPOP score. Pediatric Anesth 2014; 24(9):945–52.CrossRefGoogle Scholar

Wang, SM, Kain, ZN. Preoperative anxiety and postoperative nausea and vomiting in children: is there an association? Anesth Analg 2000; 90(3):571–5.CrossRefGoogle ScholarPubMed

Fortier, MA, Weinberg, M, Vitulano, LA, et al. Effects of therapeutic suggestion in children undergoing general anesthesia: a randomized controlled trial. Paediatr Anaesth 2010; 20(1):90–9.CrossRefGoogle ScholarPubMed

Jones, JE, Tabaee, A, Glasgold, R, et al. Eficacy of gastric aspiration in reducing posttonsillectomy vomiting. Arch Otolaryngol Head Neck Surg 2001; 127(8):980–4.CrossRefGoogle Scholar

Aydogan, MS, Ozturk, E, Erdogan, MA, et al. The effects of secondhand smoke on postoperative pain and fentanyl consumption. J Anesth 2013; 27(4):569–74.CrossRefGoogle ScholarPubMed

Drongowski, RA, Lee, D, Reynolds, PI, et al. Increased respiratory symptoms following surgery in children exposed to environmental tobacco smoke. Pediatr Anesth 2003; 13(4):304–10.CrossRefGoogle ScholarPubMed

De Windt, AC, Asehnoune, K, Roquilly, A, et al. An opioid-free anaesthetic using nerve blocks enhances rapid recovery after minor hand surgery in children. Eur J Anaesthesiol 2010; 27(6):521–5.CrossRefGoogle ScholarPubMed

Gupta, N, Kumar, R, Kumar, S, et al. A prospective randomised double blind study to evaluate the effect of peribulbar block or topical application of local anaesthesia combined with general anaesthesia on intra-operative and postoperative complications during paediatric strabismus surgery. Anaesthesia 2007; 62(11):1110–3.CrossRefGoogle ScholarPubMed

Steib, A, Karcenty, A, Calache, E, et al. Effects of subtenon anesthesia combined with general anesthesia on perioperative analgesic requirements in pediatric strabismus surgery. Reg Anesth Pain Med 2005; 30(5):478–83.CrossRefGoogle ScholarPubMed

Visser, K, Hassink, EA, Bonsel, GJ, et al. Randomized controlled trial of total intravenous anesthesia with propofol versus inhalation anesthesia with isoflurane-nitrous oxide – postoperative nausea and vomiting and economic analysis. Anesthesiology 2001; 95(3):616–26.CrossRefGoogle ScholarPubMed

Erdem, AF, Yoruk, O, Alici, HA, et al. Subhypnotic propofol infusion plus dexamethasone is more effective than dexamethasone alone for the prevention of vomiting in children after tonsillectomy. Paediatr Anaesth 2008; 18(9):878–83.CrossRefGoogle ScholarPubMed

Erdem, AF, Yoruk, O, Silbir, F, et al. Tropisetron plus subhypnotic propofol infusion is more effective than tropisetron alone for the prevention of vomiting in children after tonsillectomy. Anaesth Intensive Care 2009; 37(1):54–9.CrossRefGoogle ScholarPubMed

Apfel, CC, Korttila, K, Abdalla, M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Eng J Med 2004; 350(24):2441–51.CrossRefGoogle ScholarPubMed

Tramer, M, Moore, A, McQuay, H. Meta-analytic comparison of prophylactic antiemetic efficacy for postoperative nausea and vomiting: propofol anaesthesia vs omitting nitrous oxide vs total i.v. anaesthesia with propofol. Br J Anaesth 1997; 78(3):256–9.CrossRefGoogle ScholarPubMed

Tramer, M, Moore, A, McQuay, H. Omitting nitrous oxide in general anaesthesia: meta-analysis of intraoperative awareness and postoperative emesis in randomized controlled trials. Br J Anaesth 1996; 76(2):186–93.CrossRefGoogle ScholarPubMed

Blaudszun, G, Lysakowski, C, Elia, N, et al. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2012; 116:1312–22.CrossRefGoogle ScholarPubMed

Lewis, SR, Nicholson, A, Cardwell, ME, et al. Nonsteroidal anti-inflammatory drugs and perioperative bleeding in paediatric tonsillectomy. Cochrane Database Syst Rev 2013; (7):CD003591.Google ScholarPubMed

Elia, N, Lysakowski, C, Tramer, MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology 2005; 103:1296–304.CrossRefGoogle ScholarPubMed

Elia, N, Tramer, M. Ketamine and postoperative pain – a quantitative systematic review of randomized trials. Pain 2005; 113:61–70.CrossRefGoogle Scholar

Gan, TJ, Joshi, G, Zhao, SZ, et al. Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid related adverse effects. Acta Anaesthesiol Scand 2004; 48:1194–207.CrossRefGoogle ScholarPubMed

Gurbet, A, Basagan-Mogol, E, Turker, G, et al. Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements. Can J Anaesth 2006; 53:646–52.CrossRefGoogle ScholarPubMed

Elgueta, MF, Echevarría, GC, De la Fuente, N, et al. Effect of intravenous fluid therapy on postoperative vomiting in children undergoing tonsillectomy. Br J Anaesth 2013; 110(4):607–14.CrossRefGoogle ScholarPubMed

Goodarzi, M, Matar, MM, Shafa, M, et al. A prospective randomized blinded study of the effect of intravenous fluid therapy on postoperative nausea and vomiting in children undergoing strabismus surgery. Paediatr Anaesth 2006; 16(1):49–53.CrossRefGoogle ScholarPubMed

Chukudebelu, O, Leonard, DS, Healy, A, et al. The effect of gastric decompression on postoperative nausea and emesis in pediatric tonsillectomy patients. Int J Pediatr Otorhinolaryngol 2010; 74(6):674–6.CrossRefGoogle ScholarPubMed

Radke, OC, Biedler, A, Kolodzie, K, et al. The effect of postoperative fasting on vomiting in children and their assessment of pain. Paediatr Anaesth 2009; 19(5):494–9.CrossRefGoogle ScholarPubMed

Bolton, CM, Myles, PS, Carlin, JB, et al. Randomized, double-blind study comparing the efficacy of moderate-dose metoclopramide and ondansetron for the prophylactic control of postoperative vomiting in children after tonsillectomy. Br J Anaesth 2007; 99(5):699–703.CrossRefGoogle ScholarPubMed

Bolton, CM, Myles, PS, Nolan, T, et al. Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis. Br J Anaesth 2006; 97(5):593–604.CrossRefGoogle ScholarPubMed

Engelman, E, Salengros, J-C, Barvais, L. How much does pharmacologic prophylaxis reduce postoperative vomiting in children? Calculation of prophylaxis effectiveness and expected incidence of vomiting under treatment using Bayesian meta-analysis. Anesthesiology 2008; 109(6):1023–35.CrossRefGoogle ScholarPubMed

Schnabel, A, Eberhart, LH, Muellenbach, R, et al. Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review. Eur J Anaesthesiol 2010; 27(12):1044–51.CrossRefGoogle ScholarPubMed

Khalil, SN, Roth, AG, Cohen, IT, et al. A double-blind comparison of intravenous ondansetron and placebo for preventing postoperative emesis in 1- to 24-month-old pediatric patients after surgery under general anesthesia. Anesth Analg 2005; 101(2):356–61.CrossRefGoogle ScholarPubMed

Mondick, JT, Johnson, BM, Haberer, LJ, et al. Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1–48 months. Eur J Clin Pharmacol 2010; 66(1):77–86.CrossRefGoogle ScholarPubMed

Bicer, C, Aksu, R, Ulgey, A, et al. Different doses of palonosetron for the prevention of postoperative nausea and vomiting in children undergoing strabismus surgery. Drugs R D 2011; 11(1):29–36.CrossRefGoogle ScholarPubMed

Gross, D, Reuss, S, Dillier, CM, et al. Early vs late intraoperative administration of tropisetron for the prevention of nausea and vomiting in children undergoing tonsillectomy and/or adenoidectomy. Paediatr Anaesth 2006; 16(4):444–50.CrossRefGoogle ScholarPubMed

Henzi, I, Walder, B, Tramer, MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2000; 90(1):186–94.CrossRefGoogle ScholarPubMed

Aouad, MT, Nasr, VG, Yazbeck-Karam, VG, et al. A comparison between dexamethasone and methylprednisolone for vomiting prophylaxis after tonsillectomy in inpatient children: a randomized trial. Anesth Analg 2012; 115(4):913–20.CrossRefGoogle ScholarPubMed

Kim, MS, Cote, CJ, Cristoloveanu, C, et al. There is no dose-escalation response to dexamethasone (0.0625–1.0 mg/kg) in pediatric tonsillectomy or adenotonsillectomy patients for preventing vomiting, reducing pain, shortening time to first liquid intake, or the incidence of voice change. Anesth Analg 2007; 104(5):1052–8.CrossRefGoogle ScholarPubMed

Czarnetzki, C, Elia, N, Lysakowski, C, et al. Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial. JAMA 2008; 300(22):2621–30.CrossRefGoogle ScholarPubMed

Steward, DL, Grisel, J, Meinzen-Derr, J. Steroids for improving recovery following tonsillectomy in children. Cochrane Database Syst Rev 2011 (8):CD003997.Google Scholar

Mehta, D, Sanatani, S, Whyte, SD. The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children. Paediatr Anaesth 2010; 20(10):905–12.CrossRefGoogle ScholarPubMed

US Food and Drug Administration. Information for Healthcare Professionals: Intravenous promethazine and severe tissue injury, including gangrene. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm182169.htm (accessed March 15, 2015).Google Scholar

Dune, LS, Shiao, S-YPK. Metaanalysis of acustimulation effects on postoperative nausea and vomiting in children. Explore (NY). 2006; 2(4):314–20.CrossRefGoogle ScholarPubMed

Jindal, V, Ge, A, Mansky, PJ. Safety and efficacy of acupuncture in children: a review of the evidence. J Pediatr Hematol Oncol 2008; 30(6):431–42.CrossRefGoogle ScholarPubMed

McKechnie, K, Froese, A. Ventricular tachycardia after ondansetron administration in a child with undiagnosed long QT syndrome. Can J Anaesth 2010; 57(5):453–7.CrossRefGoogle Scholar

Afonso, N, Dang, A, Namshikar, V, et al. Intravenous ondansetron causing severe bradycardia: two cases. Ann Cardiac Anaesth 2009; 12(2):172–3.Google ScholarPubMed

Chandrakala, R, Vijayashankara, CN, Kumar, KK, et al. Ondansetron induced fatal ventricular tachycardia. Indian J Pharmacol 2008; 40(4):186–7.CrossRefGoogle ScholarPubMed

McDonnell, C, Barlow, R, Campisi, P, et al. Fatal peri-operative acute tumour lysis syndrome precipitated by dexamethasone. Anaesthesia 2008; 63(6):652–5.CrossRefGoogle ScholarPubMed

Osthaus, WA, Linderkamp, C, Bunte, C, et al. Tumor lysis associated with dexamethasone use in a child with leukemia. Paediatr Anaesth 2008; 18(3):268–70.CrossRefGoogle Scholar

Gunter, JB, Willging, JP, Myer, CM 3rd. Dexamethasone and postoperative bleeding after tonsillectomy in children. JAMA 2009; 301(17):1764–5; author reply 1765–6.CrossRefGoogle ScholarPubMed

Plante, J, Turgeon, AF, Zarychanski, R, et al. Effect of systemic steroids on post-tonsillectomy bleeding and reinterventions: systematic review and meta-analysis of randomised controlled trials. BMJ 2012; 345:e5389.CrossRefGoogle ScholarPubMed

Baugh, RF, Archer, SM, Mitchell, RB, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011; 144(1 Suppl):S1–30.CrossRefGoogle ScholarPubMed

Kovac, AL, O’Connor, TA, Pearman, MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial. J Clin Anesth 1999; 11(6):453–9.CrossRefGoogle ScholarPubMed

Baxter, AL, Watcha, MF, Baxter, WV, et al. Development and validation of a pictorial nausea rating scale for children. Pediatrics 2011; 127(6):e1542–9. [Erratum appears in Pediatrics 2011; 128(5):1004].CrossRefGoogle ScholarPubMed