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4 - Stem cell source

Published online by Cambridge University Press:  05 November 2013

Joseph H. Antin  and
Deborah Yolin Raley
Joseph H. Antin
Affiliation:
Dana-Farber Cancer Institute, Boston
Deborah Yolin Raley
Affiliation:
Dana-Farber Cancer Institute, Boston
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Summary

Hematopoietic progenitor cell products

Hematopoietic progenitor cell(HPC) products contain hematopoietic stem and lineage-committed progenitorcells capable of providing hematopoietic and immune reconstitution aftermyeloablative, nonmyeloablative, or reduced-intensity preparative regimens.There is no unanimity on the terminology.

  • Since stem cells are difficult to identify specifically, some authors prefer the term hematopoietic cell transplantation (HCT).

  • Others call the procedure hematopoietic stem cell transplantation (HSCT) to acknowledge that most transplantations are not successful unless stem cells are transplanted.

  • The Foundation for the Accreditation of Cellular Therapy (FACT) focuses on progenitors. Cellular therapy products can be broadly categorized as being either minimally manipulated products or more than minimally manipulated products.

    • Hematopoietic progenitor cell function

    Hematopoietic progenitor cellsadministered intravenously migrate to the marrow, where they adhere, expand,self-renew (stem cells only), and differentiate. The differentiated cellsare released into the blood, restoring blood counts and immunity. The timefrom administration of HPCs to recovery of adequate or normal blood countsis variable (see Chapter 9, Engraftment).

    Type
    Chapter
    Information
    Manual of Stem Cell and Bone Marrow Transplantation
    , pp. 9 - 14
    Publisher: Cambridge University Press
    Print publication year: 2013

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