Book contents
- Frontmatter
- Contents
- Acknowledgments
- Contributor
- 1 Rationale for transplantation
- 2 Types of transplantation
- 3 Human leukocyte antigen matching in allogeneic transplantation
- 4 Stem cell source
- 5 Pretransplant evaluation and counseling of patient and donor
- 6 Conditioning regimens
- 7 Stem cell infusion
- 8 ABO compatibility
- 9 Engraftment
- 10 Preventative care
- 11 Transplant-related complications
- 12 Overview of acute and chronic graft-versus-host disease
- 13 Acute graft-versus-host disease and staging
- 14 Graft-versus-host disease prophylactic regimens
- 15 Treatment guidelines for acute graft-versus-host disease
- 16 Chronic graft-versus-host disease
- 17 Engraftment syndrome
- 18 Infectious disease
- 19 Graft rejection and failure
- 20 Gastrointestinal complications
- 21 Oral health in stem cell transplantation
- 22 Pulmonary complications
- 23 Veno-occlusive disease
- 24 Special transfusion-related situations
- 25 Cardiovascular complications
- 26 Neurologic complications
- 27 Cystitis
- 28 Donor lymphocyte infusion
- 29 Transplantation: regulation and accreditation
- Index
11 - Transplant-related complications
Published online by Cambridge University Press: 05 November 2013
- Frontmatter
- Contents
- Acknowledgments
- Contributor
- 1 Rationale for transplantation
- 2 Types of transplantation
- 3 Human leukocyte antigen matching in allogeneic transplantation
- 4 Stem cell source
- 5 Pretransplant evaluation and counseling of patient and donor
- 6 Conditioning regimens
- 7 Stem cell infusion
- 8 ABO compatibility
- 9 Engraftment
- 10 Preventative care
- 11 Transplant-related complications
- 12 Overview of acute and chronic graft-versus-host disease
- 13 Acute graft-versus-host disease and staging
- 14 Graft-versus-host disease prophylactic regimens
- 15 Treatment guidelines for acute graft-versus-host disease
- 16 Chronic graft-versus-host disease
- 17 Engraftment syndrome
- 18 Infectious disease
- 19 Graft rejection and failure
- 20 Gastrointestinal complications
- 21 Oral health in stem cell transplantation
- 22 Pulmonary complications
- 23 Veno-occlusive disease
- 24 Special transfusion-related situations
- 25 Cardiovascular complications
- 26 Neurologic complications
- 27 Cystitis
- 28 Donor lymphocyte infusion
- 29 Transplantation: regulation and accreditation
- Index
Summary
When making a differentialdiagnosis in a patient who has undergone hematopoietic stem celltransplantation (HSCT), it is critical to have a solid understanding of theentire course of treatment. This includes transplant type (autologous orallogeneic) including intensity of chemotherapy, stem cell source (marrow,peripheral blood [PB], or cord blood), donor match (related or unrelated,matched or mismatched), interval post-HSCT (early or late),graft-versus-host disease (GVHD) prophylaxis, infectious prophylaxis,current immune suppressive medications, and length of granulocytopenia.Transplant-related toxicities can include treatment-related organ damage,infection, GVHD, or any other combination. Time course is generallyconsidered as follows: early – first 30 days when pancytopenia and thedirect effect of chemotherapy is greatest; mild – day 15 to roughly day 100;and late – after day 100. There is often an overlap in timing ofcomplications.
In the remainder of the bookyou will find information on the following transplant-relatedcomplications:
GVHD – prevention, acute and chronic;
engraftment syndrome;
infectious disease;
graft rejection and failure;
gastrointestinal complications;
oral care and complications;
pulmonary complications;
veno-occlusive disease;
special transfusion-related situations;
cardiovascular complications;
neurological complications;
cystitis;
donor lymphocyte infusion.
- Type
- Chapter
- Information
- Publisher: Cambridge University PressPrint publication year: 2013