Major Depressive Disorder (MDD) is the leading cause of disability worldwide, affecting individuals’ functioning in various life areas. Prolonged residual functional impairment is one of the risk factors for recurrence. Moreover, symptoms severity and accompanying functional disabilities negatively impact quality of life (QoL) and personal well-being, affecting the recovery process of people with MDD and their reintegration into daily life. Therefore, restoring functional abilities is no less important than reducing symptoms.

Recent changes in mental health policy have led to an expansion of client-oriented community-based services, focusing on preventing health problems and promoting QoL and well-being. A significant change can also be seen in depression evaluation and treatment, moving from traditional face-to-face therapy to hybrid care settings that incorporate remote or home-based treatments and assessments of everyday life.

While traditional assessments of symptoms and behavior often rely on questionnaires and interviews, they frequently miss the dynamic changes in daily functioning experienced by people with MDD. Clinicians primarily rely on patients’ retrospective reports regarding mood, affective state, thoughts, and behavior. However, understanding and gaining insight into day-to-day experiences requires addressing dynamic processes and changes that occur over time, rather than in a single time point. Hence, ecological momentary assessment (EMA) is a powerful and effective technique for assessing moment-to-moment function patterns in daily life.

Advancements in technology have enabled the use of computer-assisted methodology and real-time monitoring EMAs. The methodological advantages, including the circumvention of retrospective bias and increased longitudinal and ecological validity, have facilitated the widespread use of EMA in mood disorder clinical practice. Nevertheless, addressing everyday functioning using EMA remains limited in clinical research and practice.

Utilizing EMA can enhance our understanding of human experience, leading to human-centered research, design practice, and mental health care. It has the potential to reveal real everyday functioning and reflect the activities and contexts chosen and experienced by people with MDD. Addressing each patient’s unique functional profile can facilitate personalized interventions, supporting the recovery process and improving QoL.

This presentation will review the benefits of EMA in the field of mood traits, and especially EMA monitoring for daily function. Additionally, it will present recent studies using EMA and discuss advancements and clinical applications.

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Young general practitioners allocated in the rural area sustain the community healthcare frontline and endure the limited medical resources and social supports. Physician mental health could affect the quality of healthcare.

We examined the association of work-related experience with mental health in young public health physicians in the rural area.

Study promotional document was posted on the Korean Association of Public Health Doctors (PHD) website (http://kaphd.org) on July 2023. Three-hundred PHD (among the total 1,256 PHD) completed a web-based self-reported questionnaire on demographics, working experiences, and mental health on a first-come, first-served basis. Adjusted odds ratios(aOR) of depression, anxiety, lower self-esteem, and distress for working experiences in PHD were calculated in the multivariable logistic regression model with the best fit combinations of significant explanatory variables (P<0.05) in univariate logistic regression.

Distress, depression, anxiety, and lower self-esteem were reported by 39.7%, 25.3%, 11.3%, and 8.7% of the PHDs, respectively. Higher odds of worse mental health in PHD were associated with patient-physician conflicts at workplace, isolated residence from local facilities, and higher workload. Conversely, perceived expertise utilization and social connections with peers were related to the lower odds of worse mental health in PHD.

This study highlights the needs of governmental policy targeting the young general practitioners in rural area to enhance the expertise utilization and social connectedness, and to reduce the patient-physician conflict.

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34-year-old patient with multiple sporadic and brief contacts with mental health services, which he unilaterally chooses to discontinue. He has a long history of parasuicidal behavior dating back to adolescence. The patient does not report any prior diagnoses and has no history of inpatient admissions. The patient describes experiencing social isolation, lacking contact with his family of origin, and having no significant peer relationships.

The primary goal is to improve the patient’s engagement with mental health services, particularly in a case experiencing chronic, unaddressed symptoms, by utilizing intensive and structured programs. An additional objective is to address the patient’s self-identification with suicidal ideation.

The patient’s first contact with mental health services in this region of Spain was through the emergency department following a suicidal episode. During this encounter, the clinician introduced an intensive program designed to address suicidal ideation through regular visits over a set period. The patient agreed to participate and was subsequently enrolled in the PRISURE program at HGUGM in Madrid, where he received multiple sessions each month (between 2 and 4) with both a psychiatrist and a nurse from March to June 2024.

At the beginning of the program, the patient was fixated on the idea of suicide from a romantic/nihilistic perspective, displaying a pervasive rejection of interpersonal contact and a narcissistic element in interactions. He expressed persistent suicidal ideation. Over the course of frequent visits, the patient gradually began to connect with the chronic nature of his behaviors and started to identify additional symptoms. Despite partial engagement in the program, in this case with some missing consultations, his attendance at consultations improved significantly compared to his prior behaviors. An inpatient stay was initially offered and declined by the patient; however, after further consideration, he later presented to the emergency room and agreed to inpatient treatment. During the admission, a diagnostic assessment was carried out and discussed with the patient, revealing challenges in identity, object relations, and moral functioning, which were positioned within the spectrum of personality disorders, particularly highlighting narcissistic and antisocial traits.

Initially focused on his suicidal ideation, the patient, through the PRISURE program, gradually explored underlying difficulties contributing to his suicidal behavior. This process allowed him to accept further support, ultimately leading to an inpatient stay. Potential diagnoses were discussed openly with the patient, helping him to gain a clearer understanding of his lifelong challenges and enabling him to articulate these difficulties within the therapeutic context.

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One of the mechanisms underlying the pathogenesis of mental disorders, including endogenous depression, is systemic inflammation. It is of interest to study the immunological aspects of the early stages of endogenous disorders and identify subgroups of patients with immunotypes that characterize a high risk of developing the first psychotic episode.

Comparative analysis of the spectrum of inflammatory markers in patients with a juvenile depression with high and low risk of developing psychosis.

The study involved 98 women 16 to 25 years (20.9 ± 5.14 years) with depression within the framework of various nosologies (F31.3-4; F33.0-1; F60.0-9; F21.3-4; F20.01-2; F25.1). Two groups of patients without a history of psychosis were identified: group 1 (n = 47) - without symptoms of psychosis risk, group 2 (n = 51) - with depression associated with psychopathological symptoms of psychosis risk. The control group consisted of 42 healthy women of the corresponding age. The severity of depressive symptoms was assessed using the HDRS-21, the severity of negative and positive symptoms was determined using the SANS and SAPS. In group 2, the severity of attenuated positive symptoms was determined using the SOPS. The activity of the leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI), as well as the level of autoantibodies (AB) to S100B and MBP, were determined in plasma.

The groups were characterized by a statistically significant increase in both LE and α1-PI (p<0.05), and the level of AB compared to the control (p<0.05), but no significant differences were found. In group 1, clinical and biological correlations were found between LE activity and the total score on the SANS (r=0,44, p=0.002). In group 2, a negative correlation was found between LE activity and the age of onset of the disease (r=-0.3, p=0.046).

The clustering of patients by LE activity and their distribution by immunological groups showed that 29.4% and 27.5% of patients in groups 1 and 2, respectively, were characterized by a high level of inflammatory markers and the absence of an autoimmune component to neuroantigens, which is a sign of a more favorable course of the pathological process. On the contrary, 70.6% and 72.5% of patients in groups 1 and 2, respectively, were characterized by the type of inflammatory response associated with an increase in the level of AB and varying degrees of insufficiency of the functional activity of neutrophils, which is considered an unfavorable factor that aggravates the course of the disease.

Comparison of the spectrum of inflammatory markers in juvenile depression with different risk of developing psychosis indicate their significant immunological heterogeneity. The immunotype characterized by a high level of AB and insufficient LE activity can presumably be considered as a predictor of the risk of developing psychosis.

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The MAPS-T is a screening instrument currently under development in Brazil, designed for patients over 50 years of age and administered in a computerized format, either online or with assistance. Its purpose is to assess memory binding abilities, which involve integrating complex elements into unified representations, crucial for both short- and long-term memory. Conjunctive binding in short-term memory is responsible for the temporary retention of associations or combinations of features, such as color and shape. Screening instruments like the MAPS-T aim to be low-cost, quick, and non-invasive tools that provide indicators of potential clinical conditions.

To investigate the relationship between performance on memory tasks involving binding and the variables age and educational level.

A total of 33 individuals aged between 50 and 78 years (M=62.09; SD=6.67) with 6 to 35 years of education (M=19.88; SD=5.63) were evaluated. Participants with reported neurological/psychiatric conditions or uncorrected sensory impairments were excluded. Data collection was conducted on a computer by a trained administrator in sessions lasting 15 minutes. The memory binding task required the recognition of a nameable figure and the color and geometric shape surrounding it. Data were analyzed using Spearman’s correlation.

Spearman’s correlation coefficients indicated that age did not show a significant correlation with total recognition, binding score, or dichotomous score (p > 0.05), suggesting that this variable does not have a relevant association with performance in these scores. In contrast, education demonstrated a moderate and significant correlation with total recognition, binding score, and dichotomous score (p < 0.05), suggesting that more years of education are associated with better performance in these areas.

Descriptive Statistics

Education showed a positive and consistent association with performance across all test measures (total recognition, binding score, and dichotomous score). Age, in turn, did not show a significant correlation with these variables, indicating that, in this sample, education is a more important factor than age in explaining performance on the MAPS-T scores, particularly in the binding stage.

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Affective disorders are in constant rise and they are a serious medical and social problem. All the latest studies suggest that the incidence of affective disorders is about 14%, which makes them one of the most common psychiatric disorders. Because of that, there is a need for alternative forms of treatment of affective disorders.

The main goal of this study is to evaluate the effectiveness of the combined treatment of pharmacotherapy together with the Neurofeedback method in the treatment of affective disorders in adult individuals.

A prospective randomized study including a total of 100 outpatients from University Clinic of Psychiatry in Skopje. The subjects were randomly divided into 2 groups of 50 patients, of which the patients in the study group were treated with a combined treatment that includes the neurofeedback method as an augmentation to antidepressant therapy, while the control group with monotherapy with antidepressant medications. Subjects were examined for 2 months, with evaluation of despressive symptoms 2 weeks after the start of treatment, and then after 1 month, using the following psychodiagnostic instruments: psychiatric interview; short non-standardized socio-demographic questionnaire, CGI, HAMD, HAMA and Beck depression scale.

Patients in the study group, treated with a combined approach of antidepressant therapy and the neurofeedback method, showed a significantly greater reduction in symptoms of depression and anxiety compared to patients in the control group treated with antidepressants as monotherapy. According to the HAMA anxiety scale, the mean score in the study group (SG) decreased by 2.86 points (p<0.0001), compared to a decrease of 0.84 points in the control group (CG) (p=0.0017). On the Beck Depression Scale, the mean score in the decreased by 2.08 points (p<0.0001), compared to a decrease of 0.44 points in the CG (p=0.022). On the HAMD depression scale, the average score in the study group (SG) decreased by 2.42 points (p<0.0001), while in the control group (CG) the decrease was 0.12 points (p=0.63), the CGI scale showed a significant reduction in global symptoms in (SG) (p=0.0035), which further confirms the positive effects of the combined treatment.

The research shows that neurofeedback treatment in addition to pharamcological therapy leads to significant improvement in depressive and anxiety symptoms.

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Hypertriglyceridaemia as a side effect of antidepressants including venlafaxine and mirtazepine has been described in the literature. A relatively new SSRI, vortioxetine has never been reported to contribute to hypertriglyeridaemia and it is not mentioned in the prescribing information for this agent. Dyslipidaemia is an important risk factor for morbidity in people who suffer with mental illness, most often observed in patients who are prescribed antipsychotic medications. Evidence to date with antidepressant medication is mixed but may represent a clinically relevant additional cardiovascular risk.

This case report explores the possible relationship between Vortioxetine and worsening hypertriglyceridaemia in a patient with depressive illness.

Clinical case report and brief literature review

A 58 year old female, with a history of Recurrent Depressive Disorder was admitted to an acute psychiatric inpatient unit with a relapse in depressive illness with anxious distress and suicidality. Prior to admission, her medications included Mirtazepine 60mg, Duloxetine 120mg and Olanzapine 7.5mg. She had a family history of dyslipidaemia. A blood panel was taken which revealed mildly deranged lipid profile - Total Cholesterol of 7.72mmol/L (Upper limit of Normal - 5.0mmol/L); HDL 1.02mmol/L (ULN - 2.0mmol/L); LDL 5.44mmol/L (ULN - 3.0mmol/L); Triglycerides 2.78mmol/L (ULN - 2.0mmol/L).

The patient’s Duloxetine was switched to Venlafaxine and repeat lipid levels one week later revealed a dramatic rise in triglycerides to 12.16 mmol/L, and then 14.07 mmol/L 2 days later again. Venlafaxine was discontinued in view of these findings with a reduction in serum triglycerides to 11.43mmol/L within 24h.

Vortioxetine 10mg was commenced and the patient’s lipid profile was again repeated with an upswing in triglyceride levels to a peak of 15.4mmol/L within 48h of commencement. Vortioxetine was discontinued and fenofibrate was commenced to treat the patient’s dyslipidaemia due to a risk of acute pancreatitis and atherosclerotic disease. Serum triglycerides reduced to near-normal levels within days.

This case report highlights the risk of dyslipidaemia associated with antidepressant prescribing and identifies vortioxetine as an agent which may contribute to this. This patient had a number of risk factors for developing hyperlipidaemia including co-prescription with olanzapine and mirtazepine which have known metabolic effects, as well as a family history for hyperlipidaemia and a post-menopausal state. However, it was notable that her significant hypertriglyceridaemia was cause by venlafaxine, and exacerbated further by vortioxetine. Cardiovascular risk profiles must always be considered in the psychiatric patient population and we feel that this case report may add to the literature around commonly prescribed antidepressant medications and their contribution to this risk.

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The widespread use of electronic cigarettes (e-cigarettes) among adolescents and young adults has become a significant public health concern. With the rise of social media, exposure to content promoting e-cigarette use, including endorsements by influencers, has become increasingly pervasive. This overlap between social media and vaping culture may contribute to the normalization and growing use of e-cigarettes among this vulnerable population.

This article aims to systematically examine the influence of social media use and endorsements by influencers on e-cigarette use among adolescents and young adults, identifying patterns of exposure and consumption across various platforms and providing insights for future prevention and intervention strategies.

This systematic review aims to explore the impact of social media use and influencers on e-cigarette use among adolescents and young adults. A PRISMA model review was conducted across four databases: PubMed, Science Direct, Google Scholar, and Scopus. Medical Subject Heading (MeSH) terms and keywords (vape, e-cigarette, smoking, social media, influencer, adolescent) were used to search for full-text studies published in English from the last five years. The studies included focused on human subjects aged 10-21 and met predefined eligibility criteria.

Of the 1,064 articles initially identified, 37 were included after screening and removing duplicates.

Thirty-seven articles met the eligibility criteria. The analysis focused on five key social media platforms: TikTok, Instagram, YouTube, Twitter, and Facebook. However, significant methodological limitations were noted in the studies.

The research highlights a strong link between social media use and youth e-cigarette consumption. Exposure to vaping content, ads, and peer influence on social media increases the risk, particularly among younger and vulnerable groups. Social media enables both direct marketing and peer-to-peer promotion. Stricter regulations on online ads and enhanced parental controls are necessary to mitigate these risks and reduce youth vaping rates.

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The work of original research on opioid and heroin depedence is of great interest as it has a serious medical and social impact on society.

Self Compassion and forgiveness are important factors in helping psychosocial support and improving mental health that contributes to the development of person’s character.

The purpose of this study is to explore the relationship between self compassion and forgiveness in people who are receiving treatment for opiod depedence.

An incidental sample of 153 opioid users has been selected for the study.

Data were collected using:

• - The Self Compassion Scale.

• - the Heartland Forgiveness Scale.

Demographic and social background information was also gathered to complement the primary data.

It has been established that there is a positive relationship between self compassion and the ability to forgive oneshelf or others among people with opiate addiction.

Participants reported appropriate levels of self compassion and forgiveness. Some of the important finding include:

• - There is a notable relationship age of first use illicit drugs and the level of forgiveness afforded to others.

• - In substance dependency, an inverse relatioship is noted between the level of triazolobenzodiazepine abuse and self forgiveness and self compassion.

There is a chance of improving self kindness and forgiveness even among opioid addicts if these factors may be effective in combating the addictions.

Suggestions for future investigation includes:

• - Further evaluation of the age in which a person engages in illicit substances and the level of forgiveness extended to these individuals.

Assessing if the use of benzodiazepine that are not prescribed affects self forgiveness and self compassion.

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In Kyrgyzstan and other Central Asian countries, there has been a surge in advertisements for psychological services from underqualified practitioners. These individuals, often with only short-term training, market themselves as professionals while the cost of their services has risen dramatically. Vulnerable populations may be exploited financially without receiving effective care, leading to worsened outcomes.

This paper explores how the rise in underqualified practitioners and unchecked price increases for psychological services in Kyrgyzstan lead to harmful mental health outcomes. It also compares the regulatory frameworks in neighboring countries, highlighting Kazakhstan’s more structured approach.

This study utilizes a comparative analysis of the regulatory frameworks for psychological services in Kyrgyzstan, Tajikistan, Uzbekistan, and Kazakhstan. Data is sourced from governmental reports, academic studies, and analyses of online advertisements for psychological services. The focus is on licensing systems, training requirements, and the impact of rising consultation prices.

Kyrgyzstan, Tajikistan, and Uzbekistan lack adequate regulatory systems for licensing psychologists. The surge in online advertisements by underqualified practitioners has flooded the market, with many offering their services at increasingly inflated rates. These individuals often charge exorbitant prices while lacking the proper training, exacerbating mental health challenges for vulnerable populations. In contrast, Kazakhstan has introduced a structured National Qualifications Framework (SQF), which ensures that psychological services are provided by properly trained and certified professionals.

The unchecked rise of advertisements by unqualified therapists and the unlimited escalation of consultation fees in Kyrgyzstan and neighboring countries pose serious risks to public mental health. Without proper licensing and price regulation, individuals seeking help may face harmful consequences. Adopting a regulatory system similar to Kazakhstan’s, with strict licensing and certification requirements, would help ensure that psychological services are both safe and affordable. Such reforms are essential to protect the public from the exploitation and risks posed by untrained “therapists.”

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Depressive disorders often require specialised psychiatric services. Timely, appropriate medication initiation and/or change plays a crucial role in improving patient (pt) outcomes (Kraus et al. Transl Psychiatry 2019;9 127).

Describe the type of, and time to, medication changes within 12 months of the initial assessment of pts with depression recorded by specialised psychiatric care (SPC).

This cohort study leveraged Finnish pt data from 19 registries from 2014–2020. Adult pts with a depression diagnosis recorded by SPC in the Helsinki and Uusimaa region in 2015 (with no depression diagnosis given by SPC within the previous year) were included. All treatments were recorded as monotherapy or combination/augmentation therapy. The Kaplan-Meier method was used to analyse time to treatment change (TTC).

9305 pts were included; baseline characteristics are reported (Table 1). There was no change to the baseline treatment status in 39.7% of pts (Table 2). The most common change was from no medication to monotherapy (2138 pts [45.6% of those with no treatment before]). 2202 (23.7%) pts remained untreated throughout the study. Median (95% confidence interval) TTC following the initial assessment by SPC was 53 (50–56) days (Figure 1).

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Around 40% of pts referred to SPC had no prior pharmacotherapy. Monotherapy was the most common treatment provided. Almost 40% of pts had no change in their baseline treatment over 12 months, highlighting the need for further research to optimise care.

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Research has shown that staff working in clinical environments caring for frail, elderly or dying patients often must deal with high levels of emotional distress and psychological pain. Psychological defences are necessary and are part of our normal coping mechanism to deal with grief and losses but if they are not understood and recognized, may impact on staff and organizations in unhelpful and destructive ways. In resilient caregiving organizations, emotions are respected and attending to these emotions allow staff to create relationships which will help them cope with their work better.

Through interprofessional education with a reflective group, it was hoped that the improved understanding of emotions and experiences of staff and patients could directly influence clinical practice.

Participants were invited to monthly meetings of 60 minutes for 12 months. A psychodynamic perspective addressed the unconscious processes in clinical encounters. Participants were encouraged to describe how they felt and the meanings of their behaviour rather than just focusing on what happened. Group size was capped at 12 with 2 psychodynamically-oriented facilitators. Semi-structured interviews were conducted and a qualitative approach with content analysis of the transcribed interviews was adopted.

Interdisciplinary staff included nurses, psychologists, social workers, junior and senior clinicians. Our findings showed that staff in dementia care encountered significant levels of emotional distress. The major themes emerged included:

1. 1. Universality of emotions

2. 2. Psychologically safe space

3. 3. Enhancement of reflective capacity

4. 4. Sense-making in the clinical environment

The experiential group discussions allowed staff to better understand and recognize their vulnerability by providing a safe space for directed catharsis. The enhancement of reflective capacity through mirroring and universality in groups allowed members to create relationships which helped them cope with their work better. Through critical inquiry and dialogue, there was better awareness of the social, cultural, economic and political forces at work as staff were encouraged to think and respond honestly to day to day clinical and organizational pressures.

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Childhood trauma (CT), especially experiences of abuse and/or neglect, is highly prevalent. Although CT significantly impacts mental health, those who experience it often avoid seeking treatment. Stigma –negative beliefs surrounding mental-health and trauma, is a primary obstacle to seeking care. We recently developed and demonstrated the efficacy of a brief video intervention designed to reduce stigma and increase openness to mental health care among CT survivors. This intervention was tested in a controlled environment (crowdsourcing platforms) to ensure that broader dissemination would cause no harm. Given the central role social media plays in the lives of youth, it is crucial to explore how it can be leveraged to deliver evidence-based mental health interventions effectively.

The current study aimed to test the feasibility and acceptability of delivering this evidence-based intervention via social media, specifically Instagram. We hypothesized that the intervention would be both feasible (demonstrating high reach) and acceptable, generating better social media engagement metrics – such as higher link clicks and lower recruitment cost-per-click (CPC) rates, which indicate the intervention’s cost-effectiveness, compared to the control video.

An eight-day Instagram campaign in February 2024 targeted U.S. youth aged 18-24. The campaign featured a 60-second personal story video, previously shown to reduce stigma among CT survivors, and a psycho-educational control video providing generic mental health facts, lacking social-contact elements. We assessed the campaign’s total cost-effectiveness and key social media engagement metrics: Impressions (number of times the video was displayed), reach (number of distinct viewers), link clicks (engagement with treatment resources), and recruitment cost-per-click (CPC).

The campaign generated 628,000 impressions, reached 209,000 Instagram users, and resulted in 4,015 link clicks, indicating its feasibility. The intervention video outperformed the control video in all measures, achieving 2,062 link clicks with a CPC of $0.79, compared to 1,953 link clicks and a CPC of $0.84 for the control group.

The findings suggest that Instagram can effectively disseminate cost-effective interventions, potentially improving attitudes about CT and encouraging youth to seek help.

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Substance use is a major factor contributing to sleep disturbances in adolescents, whose developing brains are especially vulnerable. The previous studies have primarily focused on adults or individual substances.

This meta-analysis examined the overall association between substance use and sleep disturbances in adolescents.

Relevant studies were systematically searched across multiple databases, including CINHAL (via EBSCOHOST), PubMed, Scopus, Ovid Medline, Embase, PsychINFO (via EBSCOHOST), and Web of Science, from inception until October 2021. A random-effects model was employed to calculate pooled Odds Ratios (OR) with 95% confidence intervals (CIs). Forest plots and Cochran’s Q statistic p values were utilized to assess heterogeneity among the studies. Subgroup and meta-regression analyses were conducted to compare groups and identify sources of heterogeneity. Study quality was evaluated using the Joanna Briggs Institute tool, and sensitivity analysis was performed to test the robustness of the results.

A comprehensive search identified 16,870 studies, of which 18 were included in the review and meta-analysis (Figure 1), published between 1993 and 2021. The studies were of high quality and had a low risk of bias. The results showed that substance use significantly contributes to sleep disturbances in adolescents (OR = 1.70, 95% CI: 1.49–1.94) (Figure2). Alcohol users, coffee drinkers, and smokers were significantly more likely to experience sleep disturbances (OR = 1.77, OR = 1.58; OR = 1.66), while marijuana showed a non-significant association (OR = 1.29) (Table 1). Additionally, alcohol and smoking were significantly associated with insomnia (OR = 1.82, 95% CI: 1.43- 2.33 and OR = 1.75, 95% CI: 1.31-2.33), hypersomnolence (alcohol: OR = 1.46, 95% CI: 1.18-1-81), and sleep-related breathing disorders (S-RBD) (alcohol: OR = 2.29, 95 % CI: 1.53-3.42; smoking: OR = 2.30, 95% CI: 1.23-4.30), with coffee also significantly associated with insomnia (OR = 1.58, 95% CI: 1.30-193). There was considerable heterogeneity among the studies, however, subgroup and meta-regression analysis indicated no statistically significant sources of heterogeneity.Table 1

Association between individual substance use and sleep disturbances

OR = Odds Ratio, CI = Confidence Interval

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Substance use significantly increases the risk of sleep disturbances in adolescents, with alcohol, coffee, and smoking showing strong associations. Despite the heterogeneity among studies, the findings underscore the need for targeted interventions to mitigate these risks and improve sleep health in this population.

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Major depressive disorder (MDD) is the most heterogeneous psychiatric disorder, as over 1400 combinations of symptoms can satisfy DSM diagnostic criteria, and understanding the underlying biological heterogeneity is fundamental in the perspective of precision psychiatry. Genetic variants are responsible for part of this heterogeneity and contribute to inter-individual differences in treatment effects. Therefore, pharmacogenetic studies can identify predictors of poor treatment response and treatment-resistant depression (TRD), aid the prescription and development of targeted treatments or the prescription of early intensive treatments in patients at risk of TRD. Previous genome-wide association studies (GWASs) had limited power to identify specific variants/genes involved in TRD, but polygenic overlap between poor antidepressant response/TRD and several other traits was demonstrated, e.g., schizophrenia, attention deficit hyperactivity disorder (ADHD), and cognitive traits. As suggested by the high clinical heterogeneity of MDD, considering specific symptom profiles can improve the power to identify genetic signals associated with TRD. Other promising strategies to identify the biological mechanisms involved in TRD include the study of large population cohorts, using proxies of TRD defined from electronic health records (EHRs), and the integration of biomarkers reflecting also environmental factors, such as proteomics. These strategies and ongoing studies will be discussed during this talk, with reference to Psych-STRATA, a project within the Horizon Europe research and innovation programme (101057454; https://psych-strata.eu).

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Parent-child relationships significantly influence psychological and social development, with lasting effects on mental health. Warm and supportive relationships are linked to higher emotional well-being, while neglectful or strict parenting increases the risk of mental disorders [1]. Even non-abusive but conflictual relationships can raise the risk of psychological issues in adulthood [2][3], and stable family bonds contribute to resilience in facing life challenges [4][5].

This study aims to explore and assess the impact of parent-child relationships on mental well-being in adulthood.

This study uses a Google Forms questionnaire with six sections to assess the impact of parent-child relationships on mental well-being in adulthood. Univariate analysis was conducted in Excel, and multivariate analysis, including a logistic regression model, was performed in R Studio to measure this impact.

Approximately 65% of participants who reported a warm parental relationship exhibit high mental well-being in adulthood. In contrast, 45% of those who experienced frequent parental conflicts report symptoms of psychological disorders. Among participants who experienced neglect in their parental relationships, 55% developed signs of anxiety in adulthood, while 40% show increased resilience to challenges when family relationships during childhood were stable and secure

The parent-child relationship plays a crucial role in mental health in adulthood. Warm and stable relationships are associated with increased emotional well-being and better resilience in facing challenges. In contrast, relationships marked by neglect or conflict increase the risk of long-term psychological disorders. These findings highlight the importance of the family environment for psychological development and the prevention of mental health issues.

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Early life adversity (ELA) such as physical and emotional abuse has been recognized as an important risk factor for depression in adults. Past research has shown that ELA was associated with alteration in the hippocampus, a key region involved in stress sensitivity, emotional learning and memory. However, relatively little is known about the role of the hippocampus in the relationship between ELA and depression in adolescents.

This study aimed to investigate whether the hippocampal volume and hippocampus resting-state functional connectivity (RSFC) moderated the relationship between ELA and depressive symptom severity in adolescents with major depressive disorder (MDD).

This study included 73 adolescents with MDD (age M (SD) = 15.0 (1.5) years, 51 girls). The participants completed the Early Trauma Inventory and Children’s Depression Rating Scale to assess ELA and depressive symptom severity, respectively. Resting–state functional and structural T1 images were collected using a Siemens 3T MR scanner and preprocessed using AFNI and FreeSurfer routines. The average BOLD time-series was extracted from our regions-of-interest (ROIs), the bilateral hippocampus and dorsolateral prefrontal cortex (DLPFC). An ROI-to-ROI RSFC analysis was conducted to calculate Pearson correlation coefficients between the hippocampus and DLPFC ROIs. The correlation coefficients were transformed to Fisher’s z. We performed correlation and moderation analyses to test our moderation model (Figure 1) after controlling for age and sex.

Emotional abuse, one form of ELA, was significantly correlated with depressive symptoms in adolescents with MDD (r = 0.25, p < .05). Bilateral hippocampus – left DLPFC RSFCs moderated the association between emotional abuse and depressive symptoms in adolescents with MDD (ps < .01). The association between emotional abuse and depressive symptoms was stronger when bilateral hippocampus – left DLPFC RSFCs were lower (left hippocampus – left DLPFC RSFC, -1D: b = 3.72, SE = 1.06, p < .001; right hippocampus – left DLPFC RSFC, -1D: b = 4.15, SE = 1.04, p < .001) than when they were greater (left hippocampus – left DLPFC RSFC, +1D: b = -0.09, SE = 1.05, p = .93; right hippocampus – left DLPFC RSFC, +1D: b = -0.10, SE = 0.98, p = .69) (Figure 2). Hippocampal volumes also moderated the relationship between emotional abuse and depressive symptoms, but the results did not remain significant after correcting for multiple comparisons.

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Our findings suggest the important role of hippocampus RSFC with the DLPFC in the relationship between emotional abuse and depressive symptoms in adolescents with MDD.

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This presentation examines the complex relationship between Attention-Deficit/Hyperactivity Disorder (ADHD) and bipolar disorder in the context of suicide risk. A comprehensive literature review will first explore existing studies on the interplay between ADHD, bipolar disorder, and suicidal behavior in youth. In addition, a retrospective analysis of clinical data extracted from a large database at Hôtel-Dieu de France Hospital in Beirut will be presented. The ongoing study includes approximately 700 patient files and aims to evaluate the suicide risk over the past three years, specifically assessing the role of ADHD vulnerability and a history of hospitalization for mood disorders. The analysis will explore whether the increased suicide risk in individuals with ADHD is primarily attributed to comorbidity with bipolar disorder or inherent aspects of ADHD itself. The presentation will provide insights into the underlying pathophysiology, offering a deeper understanding of these critical associations, and will discuss implications for clinical risk assessment and intervention strategies.

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Sedentary behavior, a leading cause of preventable mortality in developed nations, has been linked to a range of health problems, including cardiovascular disease and depression. While the benefits of leisure-time physical activity are well-established, the impact of sedentary behavior within the workplace, particularly in the healthcare sector, remains under-explored.

To study the relationship between sedentary behavior and mental health among.

A cross-sectional study was conducted among administrative staff at Farhat Hached University Hospital, Sousse, from March 2024 to June 2024. Data were collected through an anonymous, self-administered questionnaire written in French and distributed to the administrative staff of Farhat Hached University Hospital. It included six sections covering sociodemographic characteristics, lifestyle habits, medical data, physical activity. Mental health, was assessed using the Hospital Anxiety and Depression Scale (HAD) and the Perceived Stress Scale (PSS).

A total of 85 questionnaires were completed by administrative staff at Farhat Hached University Hospital. The majority of participants were female (sex ratio of 0.42), with an average age of 47.1 ± 8.2 years. Higher education levels were represented by 66 participants, and only 24 engaged in professional physical activity (<30 minutes per day). The average seniority at the institution was 19.91 ± 9.2 years. Administrative managers (25.9%) and administrative staff (20%) were the main professional categories. A significant proportion of participants exhibited signs of anxiety (25.8%) and depression (32.9%). The average perceived stress score was 17.75 ± 4.95. A significant association was found between anxiety and low levels of physical activity at work (p<0.001). However, no significant association was observed between perceived stress and physical activity at work.

Sedentary behavior at work is associated with a high prevalence of anxiety and depressive disorders among hospital administrative staff, highlighting the importance of promoting physical activity to improve mental health.

None Declared